Clinical trials: Atherosclerosis Cerebral
Prevention & Control
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction…
- Trial name
- COMPASS (NCT01776424)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Aspirin, Pantoprazole
- Where
- 565 sites in United States, Argentina and 31 more
- Volunteers
- 27,395 people
- Sponsor
- Bayer
Atherosclerotic Vascular Disease, Coronary Arterial Disease (CAD)
Genetic Testing of CYP2C19 in Prognostic Evaluation of Long-Term Major Adverse Cardiac and Vascular Events
Several studies have shown that the efficacy of clopidogrel for secondary prevention of major adverse cardiovascular events (MACE), including acute coronary syndrome, depends on the polymorphism of the CYP2C19 gene.
- Conditions
- Atherosclerotic Vascular Disease, Coronary Arterial Disease (CAD), Atherosclerosis of Coronary Artery, Atherosclerosis of Arteries of the Extremities, Unspecified
- Trial name
- UF-GENOTYPE (NCT06855394)
- Where
- 2 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- University of Florida
Vertebrobasilar Ischemia
Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis
The purpose of this study is to investigate whether remote ischemic conditioning(RIC) would reduce the stroke risk of patients with symptomatic vertebrobasilar lesion of atherosclerosis,then we would observe the haemodynamics and…
- Trial name
- NCT02971462
- Testing
- ischemic conditioning
- Volunteers
- 80 people
- Sponsor
- Ji Xunming
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
This is a prospective, randomized, open-label, parallel-controlled clinical trial to evaluate the efficacy and safety of targeted IL-17A inhibition with secukinumab on cardiovascular and renal endpoints in 100 patients with…
- Conditions
- Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, Coronary Artery Disease
- Trial name
- NCT07704190
- Testing
- Secukinumab (75 mg), Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Cerebral Atherosclerosis
Study on Prevention and Treatment of Atherosclerotic Cerebral Occlusive Disease With Remote Ischemic Conditioning
The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) together with conventional medication therapy compared with only medication therapy reduces the 3-month risk of composite…
- Trial name
- NCT04470492
- Testing
- Doctormate®+Medical Management, Medical Management
- Volunteers
- 700 people
- Sponsor
- Ji Xunming,MD,PhD
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Atherosclerosis, Atheroma of Cerebral Arteries
Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population
the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.
- Conditions
- Atherosclerosis, Atheroma of Cerebral Arteries, Atheroma; Carotid Artery, Atheroma; Cerebral
- Trial name
- NCT03252652
- Testing
- vascular duplex ultrasound imaging
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atheroscleroses, Cerebral, Intracranial Atherosclerosis
Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)
To study the clinical outcomes after implantation of balloon-expandable drug-eluting stents in patients with symptomatic intracranial atherosclerotic stenosis in prevention of composite event of any stroke and death within 30…
- Conditions
- Atheroscleroses, Cerebral, Intracranial Atherosclerosis, Ischemia Stroke
- Trial name
- NCT06614972
- Testing
- Balloon-expandable drug-eluting stent
- Volunteers
- 520 people
- Sponsor
- RenJi Hospital
Carotid Atherosclerosis, Atherosclerotic Plaque
99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques
The aim of this trial will be to test and validate the value of scintigraphy with injection of 99mTc-Annexin-V-128 for the detection of complicated carotid plaques
- Trial name
- ANNICA (NCT03630835)
- Testing
- 99mTc-Annexin-V-128 uptake on scintigraphy
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, Transient Ischemic Attack
Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression
Stroke has become the leading cause of death in China. It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese stroke patients.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Intracranial Artery Stenosis
- Trial name
- NCT03417063
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tsinghua University
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Brain Diseases, Ischemic Stroke
Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis
IRIS-sICAS is a multicenter, randomized, double-blind, placebo-controlled clinical trialis a multicenter, randomized, double-blind, placebo-controlled clinical trial, to assess the safety and efficacy of tocilizumab injection in…
- Conditions
- Brain Diseases, Ischemic Stroke, Ischemia, Stroke
- Trial name
- IRIS-sICAS (NCT06447701)
- Testing
- Tocilizumab, NaCl 0.9% 100ml
- Volunteers
- 486 people
- Sponsor
- Zhujiang Hospital
Stroke, Ischemic
Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke
The goal of this clinical trial is to explore the influence of chronic RIC on collateral status evaluated by DSA in ischemic stroke patients with LAA etiology.
- Trial name
- RICAS (NCT06170944)
- Testing
- Remote ischemic preconditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Carotid Atherosclerosis
Artificial Intelligence Based Comprehensive Assessment System of Carotid Plaque Stability
Stroke is a common clinical disease with high disability and mortality, which seriously threatens human life and health.Carotid atherosclerotic plaque rupture is an important pathogenic basis of ischemic stroke, so judging the…
- Trial name
- NCT04544657
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atherosclerosis, Coronary, Emotional Stress
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood.
- Conditions
- Atherosclerosis, Coronary, Emotional Stress, Inflammation, Hematopoiesis
- Trial name
- NCT04853511
- Testing
- OCT-FLIM (optical coherence tomography-fluorescence life time)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Stroke, Acute Ischemic, PCSK9 Inhibitor
The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile
The goal of this clinical trial is to test the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitors) in acute ischemic stroke patients associated with atherosclerosis by investigating 1.
- Trial name
- NCT06083961
- Testing
- Alirocumab
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Sun U. Kwon
Atherosclerosis
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated…
- Trial name
- CANTOS (NCT01327846)
- Testing
- Canakinumab, Standard of care
- Where
- 1,131 sites in United States, Argentina and 38 more
- Volunteers
- 10,066 people
- Sponsor
- Novartis Pharmaceuticals
Atheroma; Carotid Artery, Atheromatosis
Assessment of Platelet-derived GARP in Atherosclerotic Disease
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions.
- Trial name
- CAPGAD (NCT07364058)
- Testing
- Tissue sample and data collection
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Université Catholique de Louvain
Intracranial Atherosclerosis
Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China
This is a prospective, multi-center, non-randomized trial to study one-year outcomes of the Wingspan system for the treatment of Chinese patients with symptomatic atherosclerotic severe intracranial stenosis.
- Trial name
- WingspanSSIR (NCT00685308)
- Testing
- Stenting of atherosclerotic intracranial stenosis
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, China
Atherosclerosis, Stroke, Ischemic
Adherence to Secondary Prevention Guidelines for Cardiovascular Risk
The present observational study aims to determine the degree of adherence to the recommendations of clinical guidelines regarding the prevention of cardiovascular complications in patients hospitalized due to a cardiovascular…
- Conditions
- Atherosclerosis, Stroke, Ischemic, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- NCT06450561
- Testing
- cardiovascular event
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf