Clinical trials: Atherosclerosis Cerebral
Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack
Comparison of Eversion and Conventional Techniques in Carotid Endarterectomy
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent…
- Conditions
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- Trial name
- NCT07288164
- Testing
- Carotid endarterectomy, conventional, Carotid endarterectomy, eversion
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Kastamonu University
Ischemic Stroke, Atheroscleroses, Cerebral
Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
- Trial name
- NCT03291652
- Testing
- DSA/3DRA
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Ischemic Heart Disease, Congestive Heart Failure
Registry of Cardiovascular Disease Patients
A computerized registry of cardiovascular disease patients in a large health maintenance organization in Israel. The registry is aimed to be used by health professionals to identify cardiovascular disease patients and to follow…
- Conditions
- Ischemic Heart Disease, Congestive Heart Failure, Peripheral Vascular Disease, Cerebrovascular Disease
- Trial name
- CVD Registry (NCT01759225)
- Where
- Israel
- Volunteers
- 110,000 people
- Sponsor
- Maccabi Healthcare Services, Israel
Cardiovascular Diseases, Heart Diseases
Reducing Total Cardiovascular Risk in an Urban Community
PLEASE NOTE: THIS STUDY IS ONLY ENROLLING PATIENTS CURRENTLY BEING TREATED AT BELAIR-EDISON FAMILY HEALTH CENTER. The purpose of this study is to compare the clinical effectiveness and cost effectiveness of two cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- COACH (NCT00241904)
- Testing
- Lifestyle Changes, Antiplatelet Agents, Beta Blocker
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- Johns Hopkins University
Atherosclerosis, Carotid Atherosclerosis
Visualization of Carotid Atherosclerosis by 68Ga-MSA
Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the…
- Conditions
- Atherosclerosis, Carotid Atherosclerosis, Noninvasive Imaging of Atherosclerosis
- Trial name
- NCT01893489
- Testing
- 68Gallium-MSA
- Where
- 2 sites in South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Korea University
Ischemic Stroke, Atherosclerosis
Preventive Effects of Ginseng Against Atherosclerosis
This study is a 12-month, double-blind, randomized, placebo-controlled trial. The purpose of this study is to determine whether ginseng is effective in the prevention of atherosclerosis and subsequent ischemic stroke.
- Trial name
- PEGASUS (NCT02796664)
- Testing
- Ginseng
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Dae Chul Suh
Carotid Atherosclerosis, Coronary Atheroscleroses
Carotid Atherosclerosis in Predicting Coronary Artery Disease
Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis.
- Trial name
- CACA (NCT06253962)
- Testing
- coronary agiongraphy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Carotid Stenosis
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
- Trial name
- NCT00670202
- Testing
- Fasudil Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Memory Disorders, Alzheimer's Disease
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer's type…
- Trial name
- NCT00031018
- Testing
- Aricept, IFN-alpha2A
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Carotid Atherosclerosis, Carotid Intimal Medial Thickness 1
Effects of Lutein Supplementation on Subclinical Atherosclerosis
This study is to investigate the possible positive effects of lutein and lycopene supplementation on early atherosclerosis in Beijing.
- Trial name
- NCT01534533
- Testing
- Lutein group, Combination group, Normal lutein control group
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Peking University
Atherosclerosis, Coronary Disease
Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis
To evaluate whether specific lipoprotein(a) apheresis on the top of optimal medical therapy could affect atherosclerotic disease burden in coronary and carotid arteries of coronary heart disease patients with elevated Lp(a)…
- Conditions
- Atherosclerosis, Coronary Disease, Carotid Artery Diseases
- Trial name
- LaRCA (NCT02133807)
- Testing
- Specific Lp(a) apheresis
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Russian Cardiology Research and Production Center
Carotid Atherosclerosis
Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile.
- Trial name
- NCT01000181
- Testing
- PET-CT with CuATSM
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London
Carotid Atherosclerosis
Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound
This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque…
- Trial name
- NCT04643431
- Testing
- Perflutren
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Carotid Artery Diseases, Stroke
Clinical and Laboratory Biomarkers in Patients With Atherothrombotic Stroke
Aim of the present study is to investigate molecular and clinical markers in patients with atherosclerotic carotid stenosis (ACAS) in the ischemic stroke acute phase.
- Trial name
- CLAST (NCT02450721)
- Testing
- Biomarkers serum level measurement
- Where
- Russia
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- St. Petersburg State Pavlov Medical University
PET/MR, Stroke Ischemic
PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Research Purpose: This project focuses on clinical research issues in the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis.
- Trial name
- PMQIC (NCT07079345)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Protein; Disease, Carotid Artery Plaque
The Proteomic Study and Early Intervention Study of Carotid Unstable Plaque
A study on the prediction model of carotid unstable plaque protein and its early intervention. Protein antibody chip was used to detect the remaining biological samples, and patients with carotid artery unstable plaque with…
- Conditions
- Protein; Disease, Carotid Artery Plaque, Traditional Chinese Medicine
- Trial name
- NCT05622877
- Testing
- Qushi Formula, Zhu's Wenban Formula, Basic treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Coronary Atherosclerosis, Coronary Artery Disease
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
In a prospective international multicenter observational study, 1080 stable chest pain patients (REALITY Advanced registry of CCTA patients) with the suspected chronic coronary syndrome will be enrolled.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Disease, Contrast-induced Nephropathy, Cerebrovascular Disease
- Trial name
- REALITY (NCT02440646)
- Testing
- Coronary computed tomography angiography, Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 4 sites in Estonia, Netherlands and 1 more
- Volunteers
- 1,080 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences