Clinical trials: Atherosclerosis Cerebral
ANCA-associated Primary Necrotizing Vasculitides
Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides
The purpose of this study is to assess whether rosuvastatin could reduce the subclinical markers of atherosclerosis and the incidence of major cardiovascular events in patients with primary necrotizing vasculitides.
- Trial name
- STATVAS (NCT02117453)
- Testing
- Rosuvastatin
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Artery Diseases, Atherosclerosis
Effect of Valsartan on Carotid Artery Disease
The EFFERVESCENT trial is designed to evaluate the effects of a specific ARB, called valsartan, on atherosclerosis. The investigators want to know if treatment with valsartan will increase the blood levels of markers responsible…
- Trial name
- NCT00208767
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Emory University
Acute Ischemic Stroke
Safety and Efficacy of Urinary Kallidinogenase for Large Artery Atherosclerosis Acute Ischemic Stroke
The purpose of this study is to evaluate the safety and efficacy of urinary kallidinogenase treatment in patients with large artery atherosclerotic acute ischemic stroke.
- Trial name
- NCT06137300
- Testing
- Urinary kallidinogenase for injection, Guideline-prescribed medical therapy
- Where
- China
- Volunteers
- 986 people
- Sponsor
- Yi Yang
Carotid Atherosclerosis
Sonodynamic Therapy in the Treatment of Carotid Atherosclerosis
Sonodynamic therapy (SDT) is a new treatment for carotid atherosclerotic plaque. The purpose of this study is to evaluate the safety and initial effectiveness of this technique.
- Trial name
- SMART-C (NCT03871725)
- Testing
- Sonodynamic therapy (SDT)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Ischemic Stroke, Hypercholesteremia
Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke.
- Trial name
- NCT07307989
- Testing
- statin + ezetimibe, Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Carotid Artery Disease, Stroke
Natural History of Carotid Atherosclerosis
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry.
- Conditions
- Carotid Artery Disease, Stroke, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT01521351
- Where
- Greece
- Volunteers
- 700 people
- Sponsor
- National and Kapodistrian University of Athens
Stroke
Trial to Evaluate the Ability of a Single Infusion of High-Density Lipoprotein (HDL) to Modulate Markers of Cerebral Ischaemia
The plasma concentration of high-density lipoprotein (HDL) can have anti-inflammatory, anti-oxidative and anti-thrombotic effects in addition to being able to remove cholesterol from peripheral tissues for secretion via the…
- Trial name
- REVEAL (NCT00822302)
- Testing
- Reconstituted High Density Lipoprotein, Saline
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- St George's, University of London
Carotid Artery Plaque, Atherosclerosis
IMaging Della PLAcca Carotidea
Background-White matter hyperintensities (WMH), patchy areas of hyperintense signal on T2-weighted or Fluid Attenuated Inversion Recovery sequences on brain magnetic resonance imaging (MRI), are believed to reflect cerebral…
- Conditions
- Carotid Artery Plaque, Atherosclerosis, Ischemic Stroke
- Trial name
- IMPLAC (NCT03333330)
- Testing
- Visipaque 320 and SonoVue
- Volunteers
- 75 people
- Sponsor
- Enrico Ammirati
Coronary Artery Disease, Carotid Artery Diseases
Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. This study will examine the effectiveness of a combination of cholesterol-lowering medications at decreasing the fat…
- Conditions
- Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis
- Trial name
- CPC (NCT00715273)
- Testing
- Atorvastatin, Niacin, Colesevelam
- Where
- 4 sites in United States
- Volunteers
- 217 people
- Sponsor
- University of Washington
Type 2 Diabetes Mellitus, Carotid Atherosclerosis
Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes
To investigate the effect of cilostazol compared with aspirin on carotid atherosclerosis in patients with type 2 diabetes mellitus
- Trial name
- NCT03248401
- Testing
- Cilostazol, Aspirin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Arteriosclerosis, Atherosclerosis
Early Detection of Arteriosclerosis
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or…
- Conditions
- Arteriosclerosis, Atherosclerosis, Myocardial Infarction, Stroke
- Trial name
- NCT00863967
- Volunteers
- 269 people
- Sponsor
- Kantonsspital Baselland Bruderholz
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Stroke, Transient Ischemic Attack
Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical…
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Intracranial Arterial Stenosis
- Trial name
- ANFIS (NCT04240119)
- Testing
- According to current clinical care standards
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Carotid Artery Diseases, Carotid Atherosclerosis
Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning
Cerebral hyperperfusion syndrome (CHS) was initially described as a clinical complication following carotid endarterectomy (CEA), but it may occur after both CEA and carotid artery stenting.
- Conditions
- Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Stenosis, Cerebral Hyperperfusion Syndrome
- Trial name
- NCT05800821
- Testing
- Carotid revascularization
- Where
- Belarus
- Volunteers
- 500 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Cardiovascular Diseases, Heart Diseases
Strong Heart Study
To determine morbidity and mortality from cardiovascular disease among American Indians and to compare cardiovascular disease risk factor levels among Indian groups living in different geographic areas.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Asthma
- Trial name
- NCT00005134
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
This is a single-center prospective cohort study of predictive factors related to prognosis of ischemic stroke due to large-artery atherosclerosis.
- Trial name
- NCT04847752
- Testing
- carotid artery stenting, carotid endarterectomy, Aspirin
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Atherosclerosis
18F-Flutemetamol and Plaque Vulnerability
Rationale: Amyloid beta (Ab) is mainly known for its role in Alzheimer's disease (AD) pathology. However, Ab seems not only to be involved in AD pathology, but also in atherosclerosis, which might explain the remarkable…
- Trial name
- NCT03291093
- Testing
- 18F-Flutemetamol PET/MRI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Ischemic Stroke, Atherosclerosis
The Gut and Oral Bacteria, Atherosclerosis and Ischemic Stroke Study
The main aim of this project is to demonstrate an association between gut and oral microbiota and their metabolites to carotid atherosclerosis and risk of ischemic stroke.
- Conditions
- Ischemic Stroke, Atherosclerosis, Microbiota
- Trial name
- NCT04803838
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Intracranial Aneurysm, Cerebrovascular Stenosis
Hybrid Operating Treatment of Coexistence of Intracranial Aneurysms and Cerebrovascular Stenosis
To evaluate the clinical benefits and risks of hybrid operating techniques in management of intracranial aneurysms with coexistence of atherosclerotic intracranial arterial stenosis.
- Conditions
- Intracranial Aneurysm, Cerebrovascular Stenosis, Atheroscleroses, Cerebral
- Trial name
- HOT-CIACS (NCT03204435)
- Testing
- Microsurgical aneurysmal operating techniques, endovascular techniques for cerebrovascular stenosis, endovascular techniques for intracranial aneurysms
- Where
- China
- Volunteers
- 196 people
- Sponsor
- liuxingju