Clinical trials: Atherosclerosis Cerebral
Stroke, Cerebral Infarction
Platelet Hyperreactivity to Aspirin and Stroke
STUDY QUESTIONS What is the real prevalence of platelet "resistance" to aspirin during the acute phase of stroke and after 3 months, and 1 year, as measured using different platelet function tests? Do all methods measure similar…
- Conditions
- Stroke, Cerebral Infarction, Cardiovascular Diseases, Vascular Diseases
- Trial name
- PLARAS (NCT00766896)
- Testing
- Aspirin (platelet sensitive versus platelet hyperreactivity)
- Where
- Brazil
- Volunteers
- 203 people
- Sponsor
- University of Sao Paulo
Ischemic Stroke, Atherosclerosis
The Gut and Oral Bacteria, Atherosclerosis and Ischemic Stroke Study
The main aim of this project is to demonstrate an association between gut and oral microbiota and their metabolites to carotid atherosclerosis and risk of ischemic stroke.
- Conditions
- Ischemic Stroke, Atherosclerosis, Microbiota
- Trial name
- NCT04803838
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Heart Diseases
Adipose Distribution and Atherosclerosis
To relate distribution of adipose tissue measured by a then new imaging technique, Magnetic Resonance Imaging (MRI) to extracranial carotid atherosclerosis, cardiovascular disease risk factors, and to more conventional measures…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Stenosis
- Trial name
- NCT00005348
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Stroke, Intracranial Atherosclerosis
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Intracranial atherosclerosis (ICAS) accounts for 10 to 40%, depending on ethnicity, of the 700,000 ischemic strokes in the United States every year.
- Trial name
- NCT03084523
- Testing
- Ferumoxytol Injectable Product
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Acute Coronary Syndrome
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death…
- Trial name
- AEGIS-II (NCT03473223)
- Testing
- Apolipoprotein A-I [human] (apoA-I)
- Where
- 903 sites in United States, Argentina and 47 more
- Volunteers
- 18,226 people
- Sponsor
- CSL Behring
Atherosclerosis, Cardiovascular Diseases
Prevalence & Progression of Subclinical Atherosclerosis
To evaluate subclinical atherosclerotic disease in menopausal women.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Carotid Artery Diseases
- Trial name
- NCT00006503
- Sponsor
- Rush University Medical Center
Coronary Artery Atherosclerosis
Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery
Patients undergoing cardiac surgery frequently develop neurologic complications, ranging from subtle cognitive changes to evident confusion, delirium, and stroke.
- Trial name
- NCT01310608
- Testing
- A-View
- Volunteers
- 32 people
- Sponsor
- Isala
Stroke, Coronary Artery Disease
Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass…
- Conditions
- Stroke, Coronary Artery Disease, Arrhythmia
- Trial name
- NCT00247533
- Testing
- Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Carotid Atherosclerosis
Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)
The purpose of the study is to determine if short term (6 months) treatment with statins to lower low-density lipoprotein (LDL) in vascular disease patients with carotid plaque will be associated with a measurable reduction in…
- Trial name
- NCT00388843
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Protein; Disease, Carotid Artery Plaque
The Proteomic Study and Early Intervention Study of Carotid Unstable Plaque
A study on the prediction model of carotid unstable plaque protein and its early intervention. Protein antibody chip was used to detect the remaining biological samples, and patients with carotid artery unstable plaque with…
- Conditions
- Protein; Disease, Carotid Artery Plaque, Traditional Chinese Medicine
- Trial name
- NCT05622877
- Testing
- Qushi Formula, Zhu's Wenban Formula, Basic treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Carotid Atherosclerosis
Atherosclerosis in Juvenile Mixed Connective Tissue Disease (ACTID)
This Study investigates presence of preclinical atherosclerosis in patients with Juvenile Mixed Connective Tissue Disease in Norway.
- Trial name
- ACTID (NCT03581162)
- Testing
- Carotid Ultrasound and venous blood sampling
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Atherosclerosis, Cardiovascular Diseases
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC
To evaluate common genetic variations, that in combination with exposure to tobacco smoke, may modify the risk of atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00064545
- Volunteers
- 1,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Carotid Atherosclerosis
Shear Wave Elastography for Carotid Atherosclerotic Plaques
The goal of this prospective diagnostic accuracy cohort study is to compare the accuracy of carotid atherosclerotic plaques stiffness assessed by shear wave elastography (SWE) with greyscale median values (GSM), magnetic…
- Trial name
- NCT06214429
- Testing
- Vascular Ultrasound, Shear Wave Elastography, Greyscale Median
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Coronary Artery Disease, Stroke
The SMART-ORACLE Study
After having had a first cardiovascular event, there is a considerable risk of developing a subsequent event. Only recently, a risk prediction model was developed for this group of patients.
- Conditions
- Coronary Artery Disease, Stroke, Peripheral Arterial Disease, Hypertension
- Trial name
- SMART-ORACLE (NCT01932671)
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- UMC Utrecht
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Hyperlipidemias, Atherosclerosis
Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy.
- Conditions
- Hyperlipidemias, Atherosclerosis, Coronary Heart Disease, Carotid Stenosis
- Trial name
- NCT00536796
- Where
- Austria
- Volunteers
- 1,096 people
- Sponsor
- AstraZeneca
Carotid Atherosclerosis
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis
To demonstrate feasibility of imaging Cu[64]-25%-CANF-Comb uptake in the atherosclerosis of the carotid artery of patients for whom carotid artery endarterectomy surgery is planned in comparison to the carotid artery for which…
- Trial name
- NCT02417688
- Testing
- Cu[64]-25%-CANF-Comb PET-MR
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Washington University School of Medicine
Ischemic Stroke, Atherosclerosis
COlchicine iN Circulating Inflammatory Markers After StrokE (CONCISE)
The goal of this phase 2, before-and-after interventional study is to investigate the effect of colchicine treatment on serum biomarkers of inflammation in patients with a history of stroke and atherosclerosis.
- Trial name
- CONCISE (NCT06062277)
- Testing
- Colchicine 0.5 MG
- Where
- Ireland
- Volunteers
- 91 people
- Sponsor
- University College Dublin