Clinical trials: Atherosclerotic Ischemic Disease
Type 2 Diabetes, Coronary Artery Disease (CAD)
Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque.
- Conditions
- Type 2 Diabetes, Coronary Artery Disease (CAD), Atherosclerosis Cardiovascular Disease
- Trial name
- EVOLVE (NCT07237685)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Melanoma
Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma
Immune checkpoint inhibitors (ICIs) are a class of medications that are now standard in the treatment of melanoma. These are standard therapy for melanoma, but long-term side effects on disease in the heart arteries is poorly…
- Trial name
- NCT07704918
- Testing
- Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Diagnostic Accuracy Of Seismocardiography for Coronary Artery Disease
This study aims to evaluate a new, non-invasive method for detecting coronary artery disease (CAD) using seismocardiography (SCG) and gyrocardiography (GCG).
- Trial name
- HF-CAD (NCT06880120)
- Testing
- Seismocardiography (SCG) and Gyrocardiography (GCG) Diagnostic Testing
- Where
- Uzbekistan
- Volunteers
- 1,534 people, healthy volunteers welcome
- Sponsor
- Heart Force Medical Inc.
Atherosclerosis, Ischemia Limb
Efficacy and Safety Comparison of the Open Surgical and Endovascular Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D.
Endovascular revascularization and open bypass grafting above the knee show comparable results in primary 2-year patency (about 65%) in medium-length lesions - TASC II, C (Pereira et al, 2006).
- Conditions
- Atherosclerosis, Ischemia Limb, Superficial Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- NCT04588571
- Testing
- Endovascular recanalization with angioplasty and stenting with the biomimetic interwoven nitinol stent, Femoropopliteal proximal bypass
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease, Atherosclerotic Cardiovascular Disease
AI-CCTA for Predicting Cardiovascular Events in CAD
This multicenter, retrospective registry study aims to evaluate the value of artificial intelligence (AI)-derived coronary CT angiography (CCTA) parameters in predicting long-term cardiovascular events in patients with coronary…
- Trial name
- MAPLE (NCT07832175)
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease, Plaque, Atherosclerotic
Identifying Vulnerable CoronAry PLaqUes With Artificial IntElligence-assisted CT Angiography
The goal of this observational study is to develop an automatic whole-process AI model to detect, quantify, and characterize plaques using coronary CT angiography in coronary artery disease patients.
- Trial name
- VALUE (NCT06025305)
- Testing
- Intravascular imaging test, Coronary plaque assessment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jinling Hospital, China
Aortic Stenosis, Brain Infarction
Neuroprotection in Patients Undergoing Aortic Valve Replacement
To evaluate the efficacy and safety of embolic protection devices to reduce ischemic brain injury in patients undergoing surgical aortic valve replacement (AVR).
- Conditions
- Aortic Stenosis, Brain Infarction, Cerebrovascular Accident, Stroke
- Trial name
- NCT02389894
- Testing
- Embol-X Embolic Protection Device, CardioGard Cannula
- Where
- 18 sites in United States, Canada
- Volunteers
- 383 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ischemic Stroke
The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
- Trial name
- NCT00754429
- Testing
- losartan, amlodipine
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Coronary Syndrome
OPTIMIZE IDE for the Treatment of ACS
Indication for use: "The Svelte DES is indicated for improving coronary luminal diameter in patients with symptomatic heart disease, including patients with non-ST elevation MI due to discrete de novo native coronary artery…
- Trial name
- OPTIMIZE (NCT03190473)
- Testing
- DES
- Where
- 72 sites in United States, Japan and 1 more
- Volunteers
- 1,630 people
- Sponsor
- Svelte Medical Systems, Inc.
Atherosclerosis, Coronary
Effects of Rivaroxaban on Vascular FMD in Patients With Stable Atherosclerotic Vascular Diseases
The specific mechanistic benefit of rivaroxaban versus other FXa inhibitors on atherothrombotic events remain unclear. Therefore plan to initiate a prospective, randomized study to investigate the effect of rivaroxaban and…
- Trial name
- NCT06986369
- Testing
- Rivaroxaban 2.5 MG Oral Tablet [Xarelto]
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Coronary Artery Disease
GLOBAL Clinical Study
The GLOBAL study is an international multi-center, prospective study designed to enroll up to 10,000 consecutive eligible subjects who are clinically referred for coronary CT angiography for assessment of suspected coronary…
- Trial name
- GLOBAL (NCT01738828)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 10,000 people
- Sponsor
- Global Genomics Group, LLC
Stroke, Acute Ischemic
Immediate Angioplasty For Acute Ischemic Stroke With Severe Intracranial Atherosclerotic Stenosis
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial that aims to evaluate the effect of immediate angioplasty (with or without stenting) for acute ischemic stroke (AIS) with severe intracranial…
- Trial name
- MAGIC (NCT06437600)
- Testing
- Immediate angioplasty
- Where
- 2 sites in China
- Volunteers
- 412 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Brain Diseases, Ischemic Stroke
Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis
IRIS-sICAS is a multicenter, randomized, double-blind, placebo-controlled clinical trialis a multicenter, randomized, double-blind, placebo-controlled clinical trial, to assess the safety and efficacy of tocilizumab injection in…
- Conditions
- Brain Diseases, Ischemic Stroke, Ischemia, Stroke
- Trial name
- IRIS-sICAS (NCT06447701)
- Testing
- Tocilizumab, NaCl 0.9% 100ml
- Volunteers
- 486 people
- Sponsor
- Zhujiang Hospital
Coronary Artery Disease, Cardiac Disease
The CAROLE (CArdiac Related Oncologic Late Effects) Study
CAROLE seeks to evaluate the relationship between chest Radiation Therapy and coronary artery disease. The purpose of CAROLE is to check the heart health of women who received breast cancer treatments in the past and protect them…
- Conditions
- Coronary Artery Disease, Cardiac Disease, Cardiac Toxicity, Radiation
- Trial name
- CAROLE (NCT03235427)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Northwell Health
Intracranial Atherosclerotic Disease (ICAD) and Vasculitis
Role of Vessel Wall MRI in Differentiaition Between Intracranial Atherosclerotic Disease and Vasculitis as Causes of Ischemic Stroke
This work aims to clarify the diagnostic ability of vessel wall MRI to differentiate between intracranial atherosclerotic disease and vasculitis as causes of ischemic stroke, thereby guiding appropriate treatment and improving…
- Trial name
- NCT07448454
- Testing
- MRI
- Volunteers
- 46 people
- Sponsor
- Assiut University
Obesity, Coronary Artery Disease
Effects of Aerobic Exercise in Obese Patients with Atherosclerotic Cardiovascular Disease
Obesity is classified using body mass index (BMI) (BMI ≥25 overweight, BMI ≥30 obese, BMI ≥40 morbidly obese). Obese patients are Class 1 according to BMI; BMI:30-34.9 and Class 2; BMI: It is classified as 35-39.9.
- Trial name
- NCT06318741
- Testing
- aerobic exercise on the treadmill+For both groups, patients will be recommended joint range of motion (ROM), stretching, strengthening, posture and balance and flexibility exercises for all joints., Walking at an intensity of 12-13 RPE+For both groups, patients will be recommended ROM, stretching, strengthening, posture and balance and flexibility exercises for all joints.
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kayseri City Hospital
Myocardial Ischemia
Comparative Study of Magnetocardiography and Emission Computed Tomography.
Coronary atherosclerotic heart disease (CHD) and Coronary Microvascular Disease (CMVD), as the primary etiologies of myocardial ischemia, have garnered increasing clinical attention due to their high prevalence and severe…
- Trial name
- NCT07078266
- Testing
- Magnetocardiography examination
- Volunteers
- 218 people
- Sponsor
- Yang Jing
Coronary Artery Disease
Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic Plaque
The aim of this prospective, open-label, randomized, single center study is to compare the effect of usual dose rosuvastatin plus ezetimibe and high-dose rosuvastatin on modifying atherosclerotic plaque.
- Trial name
- Rosuzet-IVUS (NCT03169985)
- Testing
- Rosuvastatin 10 mg plus ezetimibe 10 mg orally once a day, Rosuvastatin 20 mg orally once a day
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Samsung Medical Center
Stroke, Ischemic, Intracranial Atherosclerosis
Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling
The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS).
- Trial name
- NCT05623943
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Intracranial Atherosclerosis
Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR.
The aim of this study was to determine the diagnostic accuracy of MR-FFR to detect functionally significant ICAS comparing with pressure-wire-based FFR.
- Trial name
- NCT05631470
- Testing
- MR screening
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Xuanwu Hospital, Beijing