Clinical trials: Atopic Skin
Atopic Dermatitis, Psoriasis
Determinants of Chronic Inflammatory Skin Disease Trajectories
Although it is well known that the clinical expression and course of chronic inflammatory skin diseases are highly variable, there are insufficient epidemiological data on this, and the factors that determine the manifestation…
- Conditions
- Atopic Dermatitis, Psoriasis, Lichen Planus, Alopecia Areata
- Trial name
- NCT05928169
- Testing
- Topical and systemic drugs
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Atopic Dermatitis
Clinical Observation of Topical Lidocaine Cream Combined With Moisturizing Cream in the Treatment of Atopic Dermatitis
Twenty-five patients with atopic dermatitis applied lidocaine cream plus a moisturizer to the right limb and lidocaine cream alone to the left limb, twice daily for four weeks.
- Trial name
- NCT07067541
- Testing
- Control lidocaine cream, Experimental lidocaine cream + moisturizer cream
- Where
- China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Atopic Dermatitis
A Phase II Study of Bermekimab (MABp1) in Patients With Moderate to Severe Atopic Dermatitis
A Phase 2 study of Bermekimab (MABp1) in patients with atopic dermatitis.
- Trial name
- NCT03496974
- Testing
- Bermekimab Monoclonal Antibody 200 mg, Bermekimab Monoclonal Antibody 400 mg
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Janssen Research & Development, LLC
Atopic Dermatitis
IDA (Immunothérapie de la Dermatite Atopique) Adult - Immunotherapy in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. AD is very frequent, and involves T lymphocytes cells. Measles vaccination, as well as measles vaccine, induces a temporary immunosuppression; furthermore, an…
- Trial name
- IDA-Adult (NCT00820820)
- Testing
- ROUVAX
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Atopic Dermatitis
Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis
Various clinical studies have evaluated the role of probiotics in children with atopic dermatitis, with some studies showing improvement in clinical outcome after supplementation of probiotics and others showing no additional…
- Trial name
- NCT04706559
- Testing
- Probiotic sachet containing mixture of four strains i.e.Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, and Saccharomyces boulardii, Conventional treatment
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Atopic Dermatitis
The Effect of Gladskin on Disease Severity and the Skin Microbiome, Including Staphylococcus Aureus, in Patients With Atopic Dermatitis
Colonization with Staphylococcus aureus is related to inflammation in atopic dermatitis. Gladskin is a product for topical use containing the proprietary enzyme Staphefekt SA.100, which has the ability to specifically lyse the…
- Trial name
- NCT02840955
- Testing
- Staphefekt SA.100
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Dermatitis, Atopic
Study of Dupilumab Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
This is a randomized, double-blind, placebo-controlled, parallel group study to confirm the efficacy and safety of Dupilumab monotherapy in adults with moderate-to-severe atopic dermatitis (AD).
- Trial name
- SOLO 1 (NCT02277743)
- Testing
- Dupilumab
- Where
- 101 sites in United States, Bulgaria and 8 more
- Volunteers
- 671 people
- Sponsor
- Regeneron Pharmaceuticals
Atopic Eczema
A Pilot Study of Efficacy and Safety of SIM05 in Adults With Atopic Eczema
Atopic eczema causes significant disease burdens worldwide. Some studies reported gastrointestinal symptoms in eczema patients which could be related to gut microbiota change.
- Trial name
- NCT06230991
- Testing
- SIM05
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Atopy, Atopic Dermatitis Eczema
Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children Over Time
This is an observational cohort study of 221 breast-feeding mother-infant dyads delivered at term. The goal of the study is to investigate whether levels of immune-related microRNAs (miRNAs) in maternal breast milk (MBM)…
- Conditions
- Atopy, Atopic Dermatitis Eczema, Wheezing, Food Allergy in Infants
- Trial name
- IMPACT (NCT04017520)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Atopic Dermatitis
Dynamic Blood Inflammatory Profile in Atopic Dermatitis Patients (ADAMUNE)
This is a prospective, single-center, class 2 study to better characterize the immune response in immune response in the blood of atopic dermatitis.
- Trial name
- NCT05868824
- Testing
- Blood sample
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Atopic Dermatitis
Dupilumab Skin Barrier Function Study in Atopic Dermatitis
Primary Objective: Evaluate changes in skin barrier function with transepidermal water loss (TEWL) assessed after skin tape stripping (STS) in pre-defined lesional skin in participants with moderate to severe atopic dermatitis…
- Trial name
- BALISTAD (NCT04447417)
- Testing
- Dupilumab SAR231893
- Where
- 2 sites in United States, Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sanofi
Atopic Dermatitis
Study of ATI-1777 in Patients 12 to 65 Years Old With Mild to Severe Atopic Dermatitis
This is a Phase 2b study to determine the safety, tolerability, pharmacokinetic (PK), and efficacy of ATI-1777 in patients 12 to 65 years old with mild to severe Atopic Dermatitis.
- Trial name
- NCT05432596
- Testing
- ATI-1777 2.0% w/w, ATI-1777 1.0% w/w, ATI-1777 0.5% w/w
- Where
- 32 sites in United States
- Volunteers
- 250 people
- Sponsor
- Aclaris Therapeutics, Inc.
Atopic Dermatitis
Evaluation of the Effectiveness and Safety of Immunosuppressive and Biological Therapy of Atopic Dermatitis in Childhood
This comparative study analyzes the efficacy and safety of treatment of children from 6 years of age suffering from moderate to severe atopic dermatitis using an inhibitor of IL4, IL13 and classical immunosuppressants.
- Trial name
- NCT04895423
- Testing
- Methotrexate therapy, Mycophenolate mofetil therapy, Cyclosporine therapy
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Dermatitis, Atopic
An Efficacy and Safety Study of Tacrolimus Ointment in Adult Participants With Atopic Dermatitis
The purpose of this study is to evaluate the safety and efficacy of tacrolimus ointment in treating the signs and symptoms of moderate (medium level of seriousness) to severe (very serious, life threatening) atopic dermatitis (an…
- Trial name
- NCT01828879
- Testing
- Tacrolimus
- Where
- 2 sites in Vietnam
- Volunteers
- 74 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Dermatitis, Atopic
Immunopharmacological Effects of Rituximab in Atopic Dermatitis
Protocol Title: Immunopharmacological effects of Rituximab in atopic dermatitis Study Phase: Investigator driven study Study Design: Open-label, single center.
- Trial name
- NCT00267826
- Testing
- Rituximab
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Bern
Atopic Dermatitis
Tralokinumab Monotherapy for Moderate to Severe Atopic Dermatitis - ECZTRA 2 (ECZema TRAlokinumab Trial no. 2)
Primary objective: To evaluate the efficacy of tralokinumab compared with placebo in treating moderate to severe atopic dermatitis (AD).
- Trial name
- ECZTRA 2 (NCT03160885)
- Testing
- Tralokinumab
- Where
- 115 sites in United States, Australia and 7 more
- Volunteers
- 794 people
- Sponsor
- LEO Pharma
Asthma, Eczema
Risk of Asthma in Infants With Atopic Dermatitis
Infants will be enrolled in this study if they have never been diagnosed with asthma or wheezing and have been diagnosed with atopic dermatitis or eczema.
- Conditions
- Asthma, Eczema, Dermatitis, Atopic
- Trial name
- NCT00459576
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atopic Dermatitis
A Study of AK120 (IL-4Rα) in Healthy Subjects and Subjects With Moderate- to- Severe Atopic Dermatitis
A dose escalation, first-in-human study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of AK120 in healthy subjects and subjects with moderate- to- severe atopic dermatitis
- Trial name
- NCT04256174
- Where
- 13 sites in Australia, New Zealand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akesobio Australia Pty Ltd
Atopic Dermatitis Eczema
Cosmetic Study to Improve the Appearance of Skin Afflicted With Mild to Moderate Atopic Dermatitis.
The purpose of this study is to observe the performance of a cosmetic product, AO+Mist, on the appearance of arm skin in subjects with atopic dermatitis
- Trial name
- NCT03268174
- Testing
- AO+Mist
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- AOBiome LLC
Atopic Dermatitis
Safety and Efficacy Study of Q301 in Mild to Moderate Adolescents and Adults Atopic Dermatitis Patients
This is a randomized, double-blind, vehicle-controlled, parallel-group comparison study to evaluate the safety and efficacy of Q301 Cream vs. vehicle in adolescent and adult subjects with mild to moderate AD.
- Trial name
- NCT03571620
- Testing
- Q301 Cream, Vehicle
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Qurient Co., Ltd.
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