Clinical trials: Atrial Fibrillation, Paroxysmal, open to volunteers
Ventricular Tachycardia (VT), Atrial Tachycardia
Clinical Study on the Efficiency of Rapid Arrhythmia Mapping Using EasyStars™ High Density Mapping Catheter Applications
The primary objective of this study was to evaluate the clinical feasibility, safety, and surgical characteristics of the EasyStars™ High Density Mapping Catheterin in patients with complex arrhythmias.
- Conditions
- Ventricular Tachycardia (VT), Atrial Tachycardia, Typical Atrial Flutter, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Rapid Arrhythm (NCT07079813)
- Testing
- EasyStars™ High Density Mapping Catheter
- Volunteers
- 300 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.
Atrial Fibrillation Paroxysmal
RiLuzole to Reduce Atrial FIb Study Using Holter Monitoring
Atrial fibrillation (AF) is a growing clinical problem.1 AF is a highly dynamic condition involving episodes of sinus rhythm interspersed with periods of arrhythmia, becoming more difficult to terminate over time.
- Trial name
- SOLUTION (NCT05292209)
- Testing
- Riluzole 50 MG
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Utah
Paroxysmal Atrial Fibrillation
Catheter Ablation Using a Novel Navigation and Imaging System
The objective of the ENVIsIoN study is to collect data on the use of the VERAFEYE navigation and imaging system in patients indicated to undergo a catheter ablation procedure for the treatment of Paroxysmal Atrial Fibrillation…
- Trial name
- ENVIsIoN (NCT06895187)
- Testing
- VERAFEYE System
- Volunteers
- 100 people
- Sponsor
- LUMA Vision Ltd.
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation
The NEXT PULSE study is a pre-market, prospective, multi-center, non-randomized, interventional clinical study. Adult subjects with symptomatic paroxysmal or persistent AF who provided consent will be enrolled and treated with…
- Trial name
- NEXT PULSE (NCT07575828)
- Testing
- PulseSelect Pulse Field Ablation (PFA) System
- Volunteers
- 320 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Paroxysmal Atrial Fibrillation (PAF), Atrial Flutter
Home Monitor for AA Burden Detection IIT in TWN
Primary Endpoint: Early detection rate in Atrial Arrhythmia (AA) burden Data transmission success rate for overall number of atrial burden collection during the monitoring period Secondary Endpoints: Atrial burden occurrence at…
- Trial name
- FF108 (NCT07572279)
- Where
- 4 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation
A Study of Varipulse Catheter in Participants With Paroxysmal Atrial Fibrillation Under Optimized Sedation
The main purpose of the study is to assess how well the standard ablation procedure (Varipulse Catheter) works over long term when used with different types of anesthesia in participants with symptomatic paroxysmal atrial…
- Trial name
- GreatPFA (NCT07511166)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Johnson & Johnson Medical (Shanghai) Ltd.
Atrial Fibrillation (AF), Paroxysmal AF
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
The objective of this clinical investigation is to evaluate the feasibility, safety, and effectiveness of a concomitant procedure involving the Volt PFA System and Amulet 2 device in patients indicated for both AF ablation and…
- Conditions
- Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation
- Trial name
- CLEAR (NCT07523620)
- Testing
- PVI Ablation, Left Atrial Appendage Occluder Implant
- Where
- 16 sites in Belgium, Czechia and 8 more
- Volunteers
- 240 people
- Sponsor
- Abbott Medical Devices
Paroxysmal Atrial Fibrillation
Burst Stimulation for Paroxysmal Atrial Fibrillation
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias worldwide, associated with high morbidity and mortality rates.
- Trial name
- Burst-PAF (NCT07281898)
- Testing
- Pulmonary Vein Isolation (PVI) + Superior Vena Cava Isolation (SVCI), Burst Stimulation
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Zhibing Lu
Atrial Fibrillation Paroxysmal
The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation.
- Trial name
- PF-MRI (NCT06557876)
- Testing
- Pulmonary vein isolation by pulse field ablation, Pulmonary vein isolation by cryoablation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Paroxysmal AF, Treatment Decisions
Comparative Efficacy of 100-, 200-, & 400-mg Amiodarone in Patients With Paroxysmal AF Depending on Plasma Concentration
Amiodarone is a highly effective drug for the treatment and prevention of arrhythmias. In the 1970s and 1980s, numerous experimental and clinical studies comprehensively examined the mechanisms of amiodarone's antiarrhythmic…
- Conditions
- Paroxysmal AF, Treatment Decisions, Therapeutic Drug Monitoring (TDM)
- Trial name
- AMIODETECT (NCT07487714)
- Testing
- Pharmacotherapy with amiodarone 200 mg per day, Treatment with Amiodarone at a dose 100 mg per day, Treatment with Amiodarone at a dose 400 mg per day
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Atrial Fibrillation
Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation
A prospective, single-arm, single-center study to evaluate the safety, performance, and effectiveness of the SpherePVI™ Catheter for treating paroxysmal AF.
- Trial name
- SpherePVI (NCT05144503)
- Testing
- SpherePVI™ Catheter
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF), Paroxysmal AF
PulseMagic™ TrueForce™ PAF NMPA Study
This clinical investigation is intended to demonstrate safety and effectiveness of the PulseMagic™ TrueForce™ Ablation Catheter and the PulseMagic™Pulse Field Ablation (PFA) Generator, and Columbus™ 3D EP Navigation System with…
- Conditions
- Atrial Fibrillation (AF), Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation, Atrial Arrhythmia
- Trial name
- PFATrueForce (NCT07720557)
- Testing
- PFA Ablation catheter
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.
Atrial Fibrillation (Paroxysmal)
Pulmonary Vein Isolation With the Single Shot Endoscopic Ultra-Compliant PFA Balloon for the Treatment of AF
This is a prospective, single-arm First-in-Human study to demonstrate the safety and effectiveness of the CardioFocus OptiShot Pulsed Field Ablation System for catheter ablation of atrial fibrillation (AF).
- Trial name
- VISION AF (NCT06828939)
- Testing
- pulsed field ablation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- CardioFocus
Atrial Fibrillation (AF)
Left Atrial Posterior Wall and Mitral Isthmus PF Ablation in Non-Paroxysmal AF Patients
An observational study evaluating efficacy and safety of the Varipulse catheter in pulsed-field ablation of atrial fibrillation
- Trial name
- NCT06801392
- Testing
- pulsed-field ablation
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation Paroxysmal, Cardiac Ablation
CellFX® Nanosecond Pulsed Field Ablation (PFA) 360 Catheter Ablation System for Treatment of Atrial Fibrillation
The objective of this study is to demonstrate initial safety and effectiveness of the CellFX nano-second Pulsed Field Ablation (nsPFA or nano-PFA) 360 Catheter Endocardial Ablation System in treating subjects with atrial…
- Conditions
- Atrial Fibrillation Paroxysmal, Cardiac Ablation, Cardiac Arrhythmia
- Trial name
- NCT06696170
- Testing
- CellFX nano-pFA 360 Endocardial Ablation Catheter System
- Where
- 3 sites in Belgium, Czechia and 1 more
- Volunteers
- 60 people
- Sponsor
- Pulse Biosciences, Inc.
Atrial Fibrillation - Symptomatic
Low Voltage-Directed Catheter Ablation for Atrial Fibrillation
A two-pronged approach to evaluate long term success of non-paroxysmal ablation when using a: 1. specified low voltage-directed with pulmonary vein isolation (LD+PVI) approach compared to , 2.
- Trial name
- NCT03355456
- Testing
- Radiofrequency ablation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ohad Ziv
Atrial Fibrillation Paroxysmal, Coronary Artery Disease Without Residual Ischemia
Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia
Current guidelines for the cardioversion of paroxysmal Atrial Fibrillation at the Emergency Department do not prioritize between antiarrhythmic agents and do not consider the time taken for successful cardioversion.
- Trial name
- FLECA-ED (NCT05549752)
- Testing
- Flecainide Injectable Solution, Amiodarone Injectable Solution
- Where
- 3 sites in Greece
- Volunteers
- 80 people
- Sponsor
- Hippocration General Hospital
Paroxysmal Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
Pulsed Field Ablation of SVC and PV in Paroxysmal Atrial Fibrillation (PASPA Study)
The PASPA study is a multicenter, randomized trial comparing Pulmonary Vein Isolation (PVI) alone versus PVI plus Superior Vena Cava Isolation (SVCI) using Pulsed Field Ablation (PFA) in patients with paroxysmal atrial…
- Trial name
- PASPA (NCT07191626)
- Testing
- PFA - PV + SVCI, PFA - PVI only
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation, Paroxysmal or Persistent
Reversal of Atrial Substrate to Prevent Atrial Fibrillation Cohort Study
Atrial fibrillation (AF) is a major health problem, with a prevalence of 0.4-1% of the population. It results in high healthcare costs and significant morbidity, especially for patients with severe symptoms.
- Trial name
- RASTA-Cohort (NCT06249269)
- Where
- 7 sites in Canada
- Volunteers
- 198 people
- Sponsor
- Ratika Parkash
Atrial Fibrillation (Paroxysmal)
A Study Evaluating the Effectiveness and Safety of Pulsed Field Ablation Using the FARAPULSE™ System for Electrical Isolation of Pulmonary Veins and Superior Vena Cava
This study is a prospective, single-center, single-arm clinical trial planning to screen and enroll 200 subjects. It aims to evaluate the efficacy and safety of pulsed field ablation (PFA) using the FARAPULSE™ system for…
- Trial name
- NCT07162597
- Testing
- Pulsed Field Ablation
- Volunteers
- 200 people
- Sponsor
- Shanghai Zhongshan Hospital