Clinical trials: Atrial Fibrillation Ablation
Atrial Fibrillation
Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation
Pulmonary vein isolation (PVI) combined with empiric ablation of either common sites of non-PV triggers of Atrial Fibrillation (AF) and locations that may sustain stable AF sources should be more efficacious than PVI combined…
- Trial name
- RASTA XT (NCT02019238)
- Testing
- Pulmonary Vein Isolation procedure
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation
The investigator propose to test the efficacy of adjunctive ET-GP ablation in patients undergoing redo PVI for paroxysmal AF.
- Trial name
- ADD-GP (NCT03535818)
- Testing
- Radiofrequency ablation
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Atrial Fibrillation
Evaluation of Ablation Lesions Using Cardiovascular Magnetic Resonance Imaging
Ineffective ablation lesions can cause arrhythmia recurrence after catheter ablation for cardiac arrhythmia. Ablation lesions can be created with various ablation energy modalities.
- Trial name
- ENABLE-CMR (NCT05432024)
- Testing
- Catheter ablation
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- R&D Cardiologie
Atrial Fibrillation
Non Invasive Mapping Before Ablation for Atrial Fibrillation.
RATIONALE / CONTEXT The ECG records the electrical activity propagating along cardiac cells (from the atria to the ventricles). The standard 12 ECG leads placed on the chest measure the global activation of the heart and do not…
- Trial name
- AFACART (NCT02113761)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Paroxysmal Atrial Fibrillation, Catheter Ablation Strategies
Unexcitability Along the Ablation as an Endpoint for Atrial Fibrillation Ablation
to assess the near-term (12 months) efficacy of pulmonary vein isolation.
- Trial name
- NCT01724437
- Testing
- catheter based pulmonary vein isolation
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation, Atrial Flutter
A Comparative Study Evaluating the Vein of MArshall Ethanol Infusion Ablation Using an Over-the-wire (OTW) Balloon Versus a microcatHeter in Patients With Atrial Fibrillation
The goal of this study is to compare OTW balloon with microcatheter in the Marshall vein alcohol ablation study. The main questions it aims to answer are: • Is there a difference in the effectiveness and safety of OTW balloon and…
- Trial name
- NCT06460831
- Testing
- Microcatheter, OTW
- Where
- 5 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
PerAF: AF Termination vs Prespecified Ablation
The design of this study is an intervention, randomized, controlled study and contains two randomized groups：（1）AF-termination group；（2）Prespecified-ablation group.
- Trial name
- NCT06837441
- Testing
- Atrial Fibrillation Termination, Prespecified Ablation
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Prospective Study on the Effectiveness and Safety of Bi-polar Pulse-field Tip-catheter Ablation for Atrial Fibrillation in China（POTENTIAL-AF）
POTENTIAL-AF is a prospective, multicentre, observational registry study evaluating the real-world effectiveness and safety of bi-polar pulse-field tip-catheter ablation (PFA) for atrial fibrillation (AF) in China.
- Trial name
- POTENTIAL-AF (NCT07627685)
- Testing
- Bi-polar Pulse-field Ablation (PFA) - LEAD-PFA System with PulsedFA catheter
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Catheter Ablation
Post-Ablation Pericarditis Reduction Study
There has not been a prospective, randomized controlled trial of colchicine to reduce post-AF ablation pericarditis in an era of newer AF ablation techniques.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Pericarditis
- Trial name
- PAPERS (NCT04906720)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- St. Vincent Cardiovascular Research Institute
Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent
Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrium; Fibrillation, Atrial Arrhythmia
- Trial name
- CLIP-AF (NCT06165510)
- Testing
- Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device., Standard Endocardial Catheter Ablation
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation
Patients undergoing FIRM guided ablation of atrial fibrillation will undergo high resolution MRI imaging to determine correlation of underlying anatomic fibrotic regions with FIRM targeted sites for ablation.
- Trial name
- NCT03444337
- Testing
- Catheter Ablation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Atrial Fibrillation
Heparin Requirements in Patients Undergoing Atrial Fibrillation Ablation on Coumadin vs NOACs
To observe, using a prospectively designed study, the effect of type of oral anticoagulant on intra-procedural heparin requirements in patients undergoing Atrial Fibrillation ablation and to assess whether ACT assay accurately…
- Trial name
- NCT03520868
- Testing
- Monitoring Anti Factor Xa level
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Atrial Fibrillation
CPVI Alone Versus CPVI Plus Low-Voltage Areas Ablation During SR Versus CPVI Plus Low-Voltage Areas Ablation During AF for the Treatment of CAF
The primary objective of this investigation is to compare the efficacy of Three different AF ablation strategies in patients with Persistent atrial fibrillation: CPVI plus Low-Voltage Areas ablation during sinus rhythm Versus.
- Trial name
- NCT06499818
- Testing
- STABLE-SR, STABLE-AF, CPVI
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yantai Yuhuangding Hospital
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation
Background Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising digital biomarker for detecting latent myocardial dysfunction and predicting cardiovascular risk.
- Trial name
- NCT07708818
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Atrial Fibrillation
DAPPAR AF Dabigatran for Peri Procedural Anticoagulation During Radiofrequency Ablation of Atrial Fibrillation
It is hypothesized that peri-ablation Dabigatran will be a safe and effective method of peri-procedural anticoagulation for Atrial Fibrillation (AF) ablation, resulting in a low rate of peri-procedural bleeding and thromboembolic…
- Trial name
- DAPPARAF (NCT01468155)
- Testing
- dabigatran
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Atrial Fibrillation (AF)
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its…
- Trial name
- POBI-PFA (NCT06929897)
- Testing
- Pulmonary Vein Isolation, Additional Left Atrial Posterior Wall Ablation, Non-PV trigger test
- Where
- South Korea
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Atrial Fibrillation
Pulmonary Vein Isolation Guided by Ablation Index (Ablation Index Registry Study)
This is a prospective, multi-center, research study designed to evaluate the acute achievement of pulmonary vein (PV) isolation with ThermoCool SmartTouch (ST) and ThermoCool SmartTouch SF (STSF) catheter using the Ablation Index…
- Trial name
- AIR (NCT03277976)
- Testing
- PVI using ThermoCool® SmartTouch® Catheter, PVI using ThermoCool® SmartTouch SF® Catheter
- Where
- Italy
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Clinica Mediterranea
Atrial Fibrillation, Obstructive Sleep Apnea
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic…
- Trial name
- NCT04814420
- Testing
- Delayed enhancement magnetic resonance imaging (DE-MRI)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tulane University
Atrial Fibrillation, Paroxysmal AF
CARTO® 3 System and Real Time Intracardiac Ultrasound
This is a prospective, multicenter, non-randomized observational study of subjects 18 years and older undergoing RF ablation with drug refractory recurrent symptomatic paroxysmal Atrial Fibrillation (AF).
- Trial name
- IUAF (NCT01716663)
- Testing
- Catheter Ablation
- Where
- 26 sites in United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Evaluation of PWI Assisted by Marshall Ethanolization in Ablation of Persistent Atrial Fibrillation
This is a prospective, randomized controlled, single-blind, multi-center clinical trial study aiming to investigate whether the strategy of posterior wall isolation (PWI) assisted by vein of Marshall ethanol infusion (VOMEI)…
- Trial name
- NCT06363604
- Testing
- VOMEI + PVI + linear ablation of mitral isthmus, Posterior wall isolation
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine