Clinical trials: Atrial Fibrillation Ablation
Atrial Fibrillation
High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation
Patients undergoing FIRM guided ablation of atrial fibrillation will undergo high resolution MRI imaging to determine correlation of underlying anatomic fibrotic regions with FIRM targeted sites for ablation.
- Trial name
- NCT03444337
- Testing
- Catheter Ablation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Atrial Fibrillation, Obstructive Sleep Apnea
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic…
- Trial name
- NCT04814420
- Testing
- Delayed enhancement magnetic resonance imaging (DE-MRI)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tulane University
Ventricular Tachycardia, Atrial Fibrillation
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
To use programmed ventricular stimulation at the time of AF ablation to define the prevalence and mechanism of inducible ventricular tachycardia (VT); pace-mapping to define the site of origin of ventricular arrhythmias; and…
- Trial name
- NCT06647459
- Testing
- EP Study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Persistent Atrial Fibrillation
PerAF: AF Termination vs Prespecified Ablation
The design of this study is an intervention, randomized, controlled study and contains two randomized groups：（1）AF-termination group；（2）Prespecified-ablation group.
- Trial name
- NCT06837441
- Testing
- Atrial Fibrillation Termination, Prespecified Ablation
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation
Background Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising digital biomarker for detecting latent myocardial dysfunction and predicting cardiovascular risk.
- Trial name
- NCT07708818
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Arrhythmias, Cardiac, Atrial Fibrillation
Clinical Cohort Study - TRUST
The "Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg" (TRUST) study is an investor-initiated, single-center, prospective clinical…
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Ventricular Tachycardia
- Trial name
- TRUST (NCT05521451)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Persistent Atrial Fibrillation
Catheter Versus Thoracoscopic Surgical Ablation Strategy in Persistent Atrial Fibrillation
Atrial fibrillation(AF)is the commonest arrhythmia worldwide and can lead to significant morbidity and mortality, posing an increasing public health burden.
- Trial name
- CASA-AF (NCT01385358)
- Testing
- Thoracoscopically Assisted Surgical Ablation, Catheter Ablation
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation, Hypertension, Pulmonary
Safety Procedure Pulmonary Artery Denervation in Addition to Pulmonary Vein Isolation Combined With Ganglionated Plexi Ablation in Patients With Persistent Atrial Fibrillation and Pulmonary Hypertension
Some patients with a long history of AF develops PH "reactive" type with an increase in pulmonary vascular resistance due to vasoconstriction or structural changes of the vascular wall.
- Conditions
- Atrial Fibrillation, Hypertension, Pulmonary, Heart Diseases, Arrhythmias, Cardiac
- Trial name
- NCT02298244
- Testing
- PV isolation + GP Ablation, PV isolation + GP ablation + Pulmonary GP ablation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krasnoyarsk Regional Hospital
Atrial Fibrillation Paroxysmal, Catheter Ablation
Randomized Trial: High Power Short Duration Versus Ablation Index
The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) varies between 80 and 90 %.
- Trial name
- NCT05251545
- Testing
- Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Medical Center
Atrial Fibrillation
Evaluation of PWI Assisted by Marshall Ethanolization in Ablation of Persistent Atrial Fibrillation
This is a prospective, randomized controlled, single-blind, multi-center clinical trial study aiming to investigate whether the strategy of posterior wall isolation (PWI) assisted by vein of Marshall ethanol infusion (VOMEI)…
- Trial name
- NCT06363604
- Testing
- VOMEI + PVI + linear ablation of mitral isthmus, Posterior wall isolation
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Wide Area Circular Ablation Versus Extra-wide Area Circular Ablation in Persistent Atrial Fibrillation
Ablation of atrial fibrillation is an established method for treatment of subjects with atrial fibrillation with goal of restoration of sinus rhythm.
- Trial name
- WACAvsEWACA (NCT02814136)
- Testing
- Ablation
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mosaic Life Care
Atrial Fibrillation
Evaluation of Optimal Ablation Index for Pulmonary Vein Isolation in Patients With AF Prospective Registry
In this study, the investigators identify the optimal AI value for achieving good acute outcomes in PVI. Through the Phase 1 study, the investigators will prospectively analyze data including ablation parameters, AI and acute…
- Trial name
- NCT03389074
- Testing
- Radiofrequency catheter ablation
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Atrial Fibrillation, Atrial Flutter
A Comparative Study Evaluating the Vein of MArshall Ethanol Infusion Ablation Using an Over-the-wire (OTW) Balloon Versus a microcatHeter in Patients With Atrial Fibrillation
The goal of this study is to compare OTW balloon with microcatheter in the Marshall vein alcohol ablation study. The main questions it aims to answer are: • Is there a difference in the effectiveness and safety of OTW balloon and…
- Trial name
- NCT06460831
- Testing
- Microcatheter, OTW
- Where
- 5 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Hybrid Versus Catheter Ablation in Persistent AF
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a lifetime risk of developing AF of 1 in 4 people aged over 40.
- Trial name
- HARTCAP-AF (NCT02441738)
- Testing
- Hybrid Ablation, Catheter Ablation
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation
DAPPAR AF Dabigatran for Peri Procedural Anticoagulation During Radiofrequency Ablation of Atrial Fibrillation
It is hypothesized that peri-ablation Dabigatran will be a safe and effective method of peri-procedural anticoagulation for Atrial Fibrillation (AF) ablation, resulting in a low rate of peri-procedural bleeding and thromboembolic…
- Trial name
- DAPPARAF (NCT01468155)
- Testing
- dabigatran
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Paroxysmal Atrial Fibrillation, Catheter Ablation
Contact Force Sensing and Pulmonary Vein Isolation
Introduction - Pulmonary vein isolation (PVI) is the cornerstone of paroxysmal atrial fibrillation (AF) ablation. Recurrences remain, however, not infrequent and are mainly due to PVs reconnection.
- Trial name
- NCT01630031
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinique Pasteur
Persistent Atrial Fibrillation
Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
The design of this study is an intervention, randomized, controlled study and contains three randomized groups：（1）PVI group；（2）PVI+PWI group;（3）PVI+PWI+EGM group.
- Trial name
- NCT07122336
- Testing
- PVI, PWI, EGM
- Where
- China
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Paroxysmal AF
CARTO® 3 System and Real Time Intracardiac Ultrasound
This is a prospective, multicenter, non-randomized observational study of subjects 18 years and older undergoing RF ablation with drug refractory recurrent symptomatic paroxysmal Atrial Fibrillation (AF).
- Trial name
- IUAF (NCT01716663)
- Testing
- Catheter Ablation
- Where
- 26 sites in United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation Ablation Procedure
Atrial Fibrillation Ablation on Gastric Motility "The AF Gut Study"
You are being scheduled to undergo an ablation procedure to treat your atrial fibrillation. Complications of ablation procedures include damage to structures near the heart from the heat energy used during the ablation procedure.
- Trial name
- NCT01396356
- Testing
- GI procedures
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Persistent Atrial Fibrillation
Liner Ablation Using Contact-force in Atrial Fibrillation
Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an important cause of atrial tachycardia.
- Trial name
- LIBCAAF (NCT03091972)
- Testing
- Pulmonary vein isolation, Contact force assisted left atrial linear ablation, left atrial linear ablation without contact force monitoring
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital