Clinical trials: Atrial Fibrillation Ablation
Longstanding Persistent Atrial Fibrillation
Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial Fibrillation
Studies have shown that taking drugs to stay out of AF has limited success. This research is designed to study heart rhythm after surgical therapy, namely by measuring if there are benefits to having surgery to treat Atrial…
- Trial name
- CRYO-AF (NCT01558635)
- Testing
- Cardioblate CryoFlex Surgical Ablation, Mitral Valve surgery, Medtronic Reveal XT Insertable Cardiac Monitor
- Where
- 4 sites in Germany, Israel and 2 more
- Volunteers
- 17 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation, Arrhythmia
Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
The (Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial) CABANA Trial has the overall goal of establishing the appropriate roles for medical and ablative intervention for atrial fibrillation (AF).
- Trial name
- CABANA (NCT00911508)
- Testing
- Left atrial ablation, Rate or Rhythm Control Therapy
- Where
- 118 sites in United States, Australia and 8 more
- Volunteers
- 2,204 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Insulin Resistance
Insulin Resistance as a Predictor of Pulsed Field Ablation Success in Atrial Fibrillation (HOMA-PULSE)
This study investigates whether insulin resistance, a metabolic condition where the body's cells respond poorly to insulin, can predict the success of atrial fibrillation (AF) ablation using pulsed field ablation (PFA)…
- Conditions
- Atrial Fibrillation, Insulin Resistance, Catheter Ablation, Artificial Intelligence
- Trial name
- HOMA-PULSE (NCT07551947)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Atrial Fibrillation, Atrial Tachycardia
Empiric Pulsed Field Pulmonary Vein Isolation During Atrial Tachycardia Ablation in Adults With Congenital Heart Disease
This is a prospective, single-arm intervention trial whereby we will test the safety and efficacy of performing pulmonary vein isolation (PVI) using pulsed field ablation (PFA) in adult patients with congenital heart disease…
- Conditions
- Atrial Fibrillation, Atrial Tachycardia, Atrial Flutter, Congenital Heart Disease
- Trial name
- NCT06969378
- Testing
- Pulsed field ablation using a pentaspline ablation catheter
- Sponsor
- Boston Children's Hospital
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
Persistent Atrial Fibrillation
Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation
The overall objective of the study is to compare and assess the clinical outcomes of the standard of care hybrid ablation using epicardial ablation in conjunction with endocardial PVI alone versus epicardial ablation in…
- Trial name
- NCT02344394
- Testing
- Medtronic Cryoballoon, Thermocool Catheter, nContact
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Paroxysmal Atrial Fibrillation
Post-Market Randomized Trial: Endoscopically- Guided Ablation vs. Radiofrequency Ablation
To compare the safety and chronic Pulmonary Vein isolation of 2 ablation types. 1. visually guided ablation (VGA) using the EAS-AC and 2. radiofrequency ablation
- Trial name
- En-GARDE (NCT01057394)
- Testing
- Endoscopically guided PVI Ablation, RF PVI Ablation
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 21 people
- Sponsor
- CardioFocus
Long Standing Persistent Atrial Fibrillation
Long-term Outcomes in Long Standing Persistent Atrial Fibrillation
Atrial fibrillation (AF) is a condition detected as an irregular heartbeat. It is the most common rhythm disturbance worldwide which can lead to significant symptoms and serious health problems (stroke and heart failure).
- Trial name
- LoTO_CASA_AF (NCT04280042)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation - Symptomatic
Low Voltage-Directed Catheter Ablation for Atrial Fibrillation
A two-pronged approach to evaluate long term success of non-paroxysmal ablation when using a: 1. specified low voltage-directed with pulmonary vein isolation (LD+PVI) approach compared to , 2.
- Trial name
- NCT03355456
- Testing
- Radiofrequency ablation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ohad Ziv
Atrial Arrhythmia, Atrial Fibrillation
AcQForce Pulsed Field Ablation-CE
The Pulsed Field Ablation System Study for Atrial Fibrillation (PFA-AF)
- Trial name
- PFA-AF (NCT05113056)
- Testing
- Acutus Medical Pulsed Field Ablation System
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Acutus Medical
Persistent Atrial Fibrillation
FIND CAN Trial: "CF-172"
The purpose of this feasibility study is to further explore characteristics of ablation targets identified by CARTOFINDER 4D LAT Algorithm in subjects with persistent atrial fibrillation and to assess the acute outcome of…
- Trial name
- FIND CAN (NCT03033641)
- Testing
- Ablation procedure
- Volunteers
- 25 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation, Persistent, Ganglionated Plexi
Ganglion Plexus Ablation in Persistent Atrial Fibrillation
This study aims to investigate the long-term efficacy and safety of incorporating ganglionated plexus ablation into radiofrequency ablation strategies for persistent atrial fibrillation.
- Conditions
- Atrial Fibrillation, Persistent, Ganglionated Plexi, Catheter Ablation
- Trial name
- NCT06181578
- Testing
- ganglionated plexus ablation
- Volunteers
- 50 people
- Sponsor
- Ning Zhou
Paroxysmal Atrial Fibrillation
IMPULSE: A Safety and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation
IMPULSE is a prospective, single-arm, multi-center, safety and feasibility study evaluating the IOWA Approach Endocardial Ablation System (FARAPULSE, Inc.) for the treatment of paroxysmal atrial fibrillation.
- Trial name
- NCT03700385
- Testing
- IOWA Approach Endocardial Ablation System
- Where
- 2 sites in Czechia, France
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Analysis of Endocavitary Electrical Signal and Surface Electrocardiogram to Predict Ablation Outcome in Persistent Atrial Fibrillation
Background : Despite recent progress in the management of patients with Atrial Fibrillation (AF), AF remains one of the main risk factor of stroke, heart failure and cardiovascular mortality in the world.
- Trial name
- ASEPAF (NCT03937089)
- Testing
- Data collection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Atrial Fibrillation, Hypertension
Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation
The objective of this trial is to determine the role of renal sympathetic denervation in the prevention of atrial fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- ERADICATE--AF (NCT01873352)
- Testing
- catheter ablation, renal sympathetic denervation
- Where
- 2 sites in United States, Russia
- Volunteers
- 302 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
Efficacy of High Density Voltage and Fractionation Map Guided Ablation in Patients With Atrial Fibrillation
The purpose of this study is to evaluate the efficacy of high density voltage and fractionation map guided ablation compared to anatomy-based circumferential pulmonary vein Isolation in patients with atrial fibrillation
- Trial name
- INVENTION (NCT03989726)
- Testing
- AF ablation
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Keimyung University Dongsan Medical Center
Atrial Fibrillation (AF)
A Prospective Observational Study Evaluating the Incidence of Silent Cerebral Lesions and Procedural Safety Following Atrial Fibrillation Ablation Using the VARIPULSE™ Pulsed Field Ablation System
Study Type: Observational Study Goal: The goal of this study is to evaluate the incidence and burden of silent cerebral lesions (SCLs) detected on brain magnetic resonance imaging (MRI) after pulsed field ablation (PFA) for…
- Trial name
- VARIACE (NCT07363278)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Atrial Fibrillation, Arrhythmia
Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial
The CABANA pilot study is designed to test the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of the elimination of atrial fibrillation (AF) is superior to current…
- Trial name
- CABANA (NCT00578617)
- Testing
- Rate Control, Ablation Therapy, Rhythm Control
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Persistent Atrial Fibrillation
Study on the Prevention of Atrial Fibrillation Recurrence After Ablation by Qidong Yixin Granule
The goal of this clinical trial is to investigate the efficacy and safety of Qidong Yixin Granules in preventing recurrence in patients after radiofrequency catheter ablation for atrial fibrillation.
- Trial name
- QDYX-AF (NCT07508618)
- Testing
- Qi Dong Yi Xin Granules
- Where
- 5 sites in China
- Volunteers
- 846 people
- Sponsor
- Sir Run Run Shaw Hospital
Atrial Fibrillation
Respiratory Motion Related Ablation Gap and Clinical Outcome After Catheter Ablation for Atrial Fibrillation
This is the evaluation which is associated with apnea symptom, one of the recurrence factors, after AF ablation to patients who diagnosed AF.
- Trial name
- NCT02216903
- Where
- South Korea
- Volunteers
- 510 people
- Sponsor
- Yonsei University