Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation (AF)
Deep Sedation vs. General Anesthesia for Pulsed Field Ablation in Atrial Fibrillation
1. Research Title: A Study on the Safety and Efficacy of Deep Sedation With Dexmedetomidine Combined With Remimazolam and Remifentanil Versus General Anaesthesia for Radiofrequency Ablation of Atrial Fibrillation 2.
- Trial name
- SAFE-PFA (NCT07621432)
- Testing
- Standardized Deep Sedation Protocol, Standard General Anesthesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Paroxysmal Atrial Fibrillation
THERMOCOOL SMARTTOUCH®SF Catheters With Ablation Index Study
A single-center, real word study of consecutive subjects who undergo radiofrequency ablation for paroxysmal AF using THERMOCOOL SMARTTOUCH®SF (STSF) Catheter guiding by Ablation Index (AI).
- Trial name
- STSF (NCT03963349)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Biosense Webster, Inc.
Congestive Heart Failure, Left Ventricular Failure
Catheter Ablation vs. Medical Therapy in Congested Hearts With AF
This study is a multi-center, randomized, unblinded, clinical trial. The objective is to determine if catheter-based atrial fibrillation (AF) ablation is superior to medical treatment in patients with impaired left ventricular…
- Conditions
- Congestive Heart Failure, Left Ventricular Failure, Atrial Fibrillation
- Trial name
- CATCH-AF (NCT02686749)
- Testing
- Catheter Ablation, FDA approved anti arrhythmic drug
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation, Atrial Fibrillation New Onset
STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation
To provide data demonstrating the safety and effectiveness of the Arctic Front Advance™ Cardiac CryoAblation Catheter for the treatment of recurrent symptomatic paroxysmal atrial fibrillation, without the requirement that the…
- Trial name
- STOP AF First (NCT03118518)
- Testing
- Cryoablation, Antiarrhythmic drug
- Where
- 24 sites in United States
- Volunteers
- 225 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation, Atrial Flutter
Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter
Atrial Flutter [AFL] is a relatively frequent arrhythmia, considered as benign, but associated with both invalidating symptoms and thromboembolic risk.
- Trial name
- PREFACE (NCT00736294)
- Testing
- Ramipril
- Where
- 8 sites in France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation and Flutter, Heart Failure
Multimodal Cardiac Imaging Registry in Patients with Atrial Fibrillation
The goal of this observational registry is to collect a curated dataset of multimodal imaging data that will serve for development of artificial-intelligence based solutions for prediction of risk and outcomes in patients with…
- Conditions
- Atrial Fibrillation and Flutter, Heart Failure, Artificial Intelligence (AI), Echocardiography
- Trial name
- IMAGE-AF (NCT06584266)
- Testing
- Transoesophageal echocardiography, Catheter ablation
- Where
- 7 sites in Czechia, Poland
- Volunteers
- 3,000 people
- Sponsor
- University in Zielona Góra
Atrial Fibrillation, Pulmonary Hypertension
Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study
Atrial fibrillation (AF) and atrial tachycardia (AT), including type I atrial flutter, are frequently observed in patients with pulmonary hypertension (PH).
- Trial name
- NCT04053361
- Testing
- Catheter ablation
- Where
- 3 sites in Czechia
- Volunteers
- 76 people
- Sponsor
- General University Hospital, Prague
Atrial Fibrillation
Characterisation of Fractionated Electrograms Critical for Maintenance of Atrial Fibrillation (AF)
The purpose of this study is to characterise which fractionated electrogram morphologies are important to target in the catheter ablation of atrial fibrillation.
- Trial name
- CAFE AF (NCT00894400)
- Testing
- catheter ablation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation, Hypertension
Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation
The objective of this trial is to determine the role of renal sympathetic denervation in the prevention of atrial fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- ERADICATE--AF (NCT01873352)
- Testing
- catheter ablation, renal sympathetic denervation
- Where
- 2 sites in United States, Russia
- Volunteers
- 302 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation (AF)
Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation
This study aims to evaluate whether acupuncture can reduce the recurrence of atrial arrhythmias after catheter ablation in patients with persistent atrial fibrillation.
- Trial name
- NCT07487532
- Testing
- Electroacupuncture, Standard Medical Therapy
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Paroxysmal Atrial Fibrillation
The Effect and Safety of Pulsed Field Ablation (PFA) in Patients With Paroxysmal Atrial Fibrillation (PAF)
This study is aimed to evaluate the Efficacy and Safety of Pulsed Field Ablation (PFA) in Patients with Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- ESPFA-CN21 (NCT05400928)
- Testing
- Pulsed Field Ablation
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Tongji Hospital
Atrial Fibrillation
Apple Watch-led Surveillance of AF Recurrence After Catheter Ablation
Atrial fibrillation (AF) is a heart rhythm disorder associated with debillitating symptoms, psychological distress and heart failure. It can also significantly increase an individuals stroke risk.
- Trial name
- AFFU-AW (NCT05016791)
- Testing
- Apple Watch-based heart rhythm monitoring
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation
The purpose of this study is to evaluate the safety and effectiveness of empirical posterior wall isolation (PWI), left atrial appendage electrical isolation (LAAEI) and coronary sinus isolation (CSI) when compared to pulmonary…
- Trial name
- PLEA (NCT04216667)
- Testing
- Catheter ablation
- Where
- 16 sites in United States, Argentina and 5 more
- Volunteers
- 124 people
- Sponsor
- Montefiore Medical Center
Atrial Fibrillation
Health Economics Evaluation of Catheter Ablation Versus Drug Therapy in Atrial Fibrillation (AF) in China
To generate real world evidence to compare clinical outcomes and patient health-related quality of life, resulting from catheter ablation therapy with clinical outcome and patient health-related quality of life resulting from…
- Trial name
- NCT01878981
- Volunteers
- 450 people
- Sponsor
- Johnson & Johnson Medical, China
Atrial Fibrillation
The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study
The aim of the Correlation Of CoAGulation-Atrial Fibrillation (COAG-AF) study is to prove that an increase in pro-thrombotic biomarkers in AF is associated with an increase in AF burden.
- Trial name
- NCT04947657
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Tulane University
Arterial Hypertension, Atrial Fibrillation
Combined Treatment of Arterial Hypertension and Atrial Fibrillation
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant/non-resistant…
- Trial name
- NCT01897545
- Testing
- Circumferential PV isolation, PV isolation+renal denervation
- Where
- 3 sites in United States, Greece and 1 more
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation, Left Atrial Appendage Closure
Registry on Luma Vision's VERAFEYE System (ENLIgHT)
The objective of the study is to compile real-world data on the use of the VERAFEYE System in standard of care atrial fibrillation (AF) ablation procedures and left atrial appendage closure (LAAC) procedures.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Closure, Atrial Arrhythmia
- Trial name
- ENLIgHT (NCT06293430)
- Testing
- VERAFEYE System
- Volunteers
- 50 people
- Sponsor
- LUMA Vision Ltd.
Atrial Fibrillation
Surgical or Catheter Ablation of Lone Atrial Fibrillation (AF) Patients
Prospective randomized interventional trial comparing the efficacy of circumferential pulmonary vein ostia ablation using surgical versus catheter techniques in the treatment of paroxysmal atrial fibrillation.
- Trial name
- SCALAF (NCT00703157)
- Testing
- Catheter Ablation, Surgical Ablation
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation
The purpose of this study is to determine if additional ablation during the first procedure as the result of the ability to medically induce quiet atrial arrhythmias will improve clinical outcome in patients with atrial…
- Trial name
- NCT03032965
- Testing
- Adenosine, Isoproterenol
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Michigan
Atrial Fibrillation, Catheter Ablation
Post-Ablation Pericarditis Reduction Study
There has not been a prospective, randomized controlled trial of colchicine to reduce post-AF ablation pericarditis in an era of newer AF ablation techniques.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Pericarditis
- Trial name
- PAPERS (NCT04906720)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- St. Vincent Cardiovascular Research Institute