Clinical trials: Atrial Fibrillation Catheter Ablation
Paroxysmal Atrial Fibrillation (PAF)
Sphere-9 PAF China Study
The goal of this clinical trial is to find out if the Sphere-9 Catheter and Affera Integrated Mapping and Ablation System is safe and works to treat recurrent symptomatic paroxysmal atrial fibrillation (PAF) in adults who have…
- Trial name
- NCT07789925
- Testing
- Catheter ablation using Sphere-9™ Catheter and Affera™ Integrated Mapping and Ablation System
- Where
- 10 sites in China
- Volunteers
- 180 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation
Vimecon CAI Trial for the Interventional Treatment of Paroxysmal Atrial Fibrillation (AF)
This study is a prospective, non-randomized, single arm, multicenter, CE marking trial for patients with paroxysmal atrial fibrillation to undergo an ablation of the cardiac tissue near the PV.
- Trial name
- CAI (NCT02770989)
- Testing
- Vimecon Laser CAI percutaneous cardiac ablation
- Where
- 3 sites in Belgium, Czechia and 1 more
- Volunteers
- 1 people
- Sponsor
- Vimecon GmbH
Paroxysmal Atrial Fibrillation
Clinical Investigation of the VytronUS Ablation System for Treatment of Paroxysmal Atrial Fibrillation
The study is a single center, open-label, single arm, prospective pre-market study designed to assess the safety and efficacy of the VytronUS Ablation System (VAS) for the treatment of atrial fibrillation in patients with drug…
- Trial name
- VALUE (NCT03639597)
- Testing
- VytronUS Ablation System
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- VytronUS, Inc.
Atrial Fibrillation, HFpEF - Heart Failure With Preserved Ejection Fraction
Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)
To investigate whether RFCA is superior to AADs in AF patients with HFpEF on the basis of optimized anti-heart-failure drug therapy regarding their longterm clinical outcomes.
- Trial name
- NCT06125925
- Testing
- Radiofrequency catheter ablation (RFCA), Medical Therapy
- Where
- China
- Volunteers
- 436 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation, Paroxysmal Atrial Fibrillation
High-Power, Short-Duration Ablation in Treatment of Patients With Atrial Fibrillation
Atrial fibrillation (AF) stands as the most common type of cardiac arrhythmia. The frequency of AF in the overall population is 1-2%, with the incidence rate increasing with age from 0.5% in the 40-50 years old to 5-15% in those…
- Conditions
- Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
- Trial name
- HPSD (NCT06415149)
- Testing
- High power short duration ablation with 50 W, High power short duration ablation with 45 W
- Where
- Russia
- Volunteers
- 185 people
- Sponsor
- People's Friendship University of Russia
Atrial Fibrillation (AF)
LA Function After PFA in Paroxysmal AF
A prospective study that investigates the changes in LA echocardiographic parameters after PFA for paroxysmal AF.
- Trial name
- NCT07439016
- Testing
- LA and LAA function measurements
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Catheter Ablation, Radiofrequency, Atrial Fibrillation
Impact of a New Ablation Tracking Tool in Paroxysmal Atrial Fibrillation Ablation With Contact Force Technology
Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. A novel technology was recently developed to allow an automatic points annotation when indirect parameters of lesion formation reach…
- Trial name
- VISITALY (NCT02681926)
- Testing
- VISITAG
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Giulio Zucchelli
Atrial Fibrillation
Atrial Fibrillation After Catheter Versus Thoracoscopic Ablation Using Patient Activated Implantable Loop Recorders: The ACTUAL Study
Atrial fibrillation (AF) is a common but often distressing condition. It can be treated with medications, but these are not always effective or tolerated.
- Trial name
- ACTUAL (NCT01503268)
- Testing
- Implantation of implantable loop recorder, Percutaneous ablation of atrial fibrillation, Surgical ablation of atrial fibrillation
- Where
- 2 sites in United Kingdom
- Sponsor
- East Sussex Healthcare NHS Trust
Atrial Fibrillation, Catheter Ablation
AF Ablation With High Power Short Duration RF
This is a prospective, multi-center, research study designed to evaluate the safety and efficacy of pulmonary vein (PV) isolation with high power short duration radiofrequency energy in patients with paroxysmal/persistent atrial…
- Trial name
- AIR HPSD (NCT05777551)
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 850 people
- Sponsor
- Clinica Mediterranea
Uncontrolled Hypertension, Atrial Fibrillation
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
The objective of the H-FIB trial is to determine the role of renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- H-FIB (NCT01635998)
- Testing
- Boston Scientific Vessix Renal Denervation System
- Where
- 8 sites in United States, Czechia and 1 more
- Volunteers
- 50 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation Ablation
Efficacy Study for Surgery After Previous Failed Catheter Ablation
Specific Aims: The primary objective of this registry is to determine the percentage of patients who are free from atrial fibrillation (AF) at 6 and 12 months following a surgical ablation procedure when the patient has a history…
- Trial name
- SAVED (NCT01034852)
- Testing
- Totally Thoracoscopic Maze
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Cardiopulmonary Research Science and Technology Institute
Atrial Fibrillation, Persistent
Thoracoscopic Surgical Versus Catheter Ablation Approaches for Primary Treatment of Persistent Atrial Fibrillation
Rationale: Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia. AF is classified as paroxysmal or persistent AF, based on the duration and persistency of the arrhythmia.
- Trial name
- APPROACH AF (NCT04715425)
- Testing
- Thoracoscopic pulmonary vein isolation without additional lesion + left atrial appendage exclusion/amputation, Catheter pulmonary vein isolation without additional lesions
- Where
- 3 sites in Netherlands
- Volunteers
- 170 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation (AF)
Assessment of Catheter Tissue Contact in PFA
Pulmonary vein isolation remains the cornerstone of invasive treatment for atrial fibrlllation. Despite recent technological advances in the field of pulsed field ablation (PFA) pulmonary vein isolation durability and arrhythmia…
- Trial name
- ASSESS PFA (NCT07721948)
- Testing
- Electrode tissue contact assessment during pulsed field ablation
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation
In recent years it has been shown that catheter ablation of symptomatic atrial fibrillation (PAF) is superior to antiarrhythmic drug therapy with regards to effectiveness and clinical outcomes.
- Trial name
- NCT02896595
- Testing
- General Anesthesia with endotracheal tube, General Anesthesia with laryngeal mask airway
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Atrial Fibrillation
Kansai Plus Atrial Fibrillation Trial
This is a 2x2 factorial randomized controlled trial (KPAF Trial), evaluating two different pharmacological approaches to improve long-term outcome of catheter ablation for atrial fibrillation (AF).
- Trial name
- KPAF (NCT01477983)
- Testing
- ATP guide additional ablation., Antiarrhythmic drug (AAD), Control
- Where
- Japan
- Volunteers
- 2,113 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Persistant Atrial Fibrillation, Paroxysmal AF
The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on Atrial Mechancis Assessed by Cardiac Magnetic Resonance Imaging
Assessing the impact of a new atrial fibrillation (AF) catheter ablation energy on left atrial structure and function is of crucial importance.
- Trial name
- PF-MRI+ (NCT07499531)
- Testing
- Atrial fibrillation ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation
Efficiency Study Evaluating the Use of PVAC Catheter Technology for Performing Ablation in Pts With Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia affecting the Canadian population. AF is associated with increased risk of stroke,HF, and even mortality.
- Trial name
- CAPCOST (NCT01562912)
- Testing
- Radiofrequency Ablation Procedure, PVAC Ablation Procedure
- Where
- 6 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Newmarket Electrophysiology Research Group Inc
Atrial Fibrillation
Pre Procedural Biomarkers Might Predict Recurrent Atrial Fibrillation After Catheter Ablation
Evaluation of the predictive value of serum levels of adipocytokines and primary phase reactant for recurrent atrial fibrillation (RAF) after catheter ablation in 26 patients had persistent and 91 patients had paroxysmal AF.
- Trial name
- NCT05114772
- Testing
- Measuring Serum bio-markers
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Tanta University
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Combined Study of ATrial Strain and Voltage by High Density Mapping in Young Patients With Atrial Fibrillation.
Atrial The treatment of atrial fibrillation (AF) includes 2 axes: the prevention of the cardio-embolic risk and rhythm control. The possibilities for this control are antiarrhythmic drugs and, above all, catheter ablation, an…
- Conditions
- Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Catheter Ablation, Atrial Cardiomyopathy
- Trial name
- CATS-AF (NCT05565183)
- Testing
- MRI (with injection of contrast product)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF), Heart Failure
Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF)
This study examines whether measuring blood pressure inside the left upper chamber of the heart during a procedure to treat an irregular heartbeat called atrial fibrillation can help identify patients who would benefit from heart…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Catheter Ablation, Guideline Implementation
- Trial name
- LAP AF-HF (NCT07594886)
- Testing
- LAP-Triggered Heart Failure Optimization Pathway
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medical College of Wisconsin