Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation, Persistent Atrial Fibrillation
Left Atrial Arrhythmia Substrate Identification After Confirmed durABLE Pulmonary Vein Isolation
Under current practice, patients with persistent atrial fibrillation, can be offered one of two types of ablation treatment. Both of these treatments are aimed at electrically isolating the 4 pulmonary veins (PVs) at the back of…
- Trial name
- LAUDABLE (NCT04111731)
- Testing
- Cryoballoon pulmonary vein isolation, Radiofrequency pulmonary vein isolation, Repeat electrophysiological study
- Where
- 3 sites in United Kingdom
- Volunteers
- 44 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Persistent Atrial Fibrillation
Epicardial Mini-Maze Versus Catheter Ablation for the Management of Persistent Atrial Fibrillation
This study will assess the efficacy of catheter ablation versus the Wolf Mini-Maze surgical ablation for rhythm control in patients with persistent afib.
- Trial name
- EMMCAF (NCT03446222)
- Testing
- Catheter ablation, Mini-maze surgical procedure
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Atrial Fibrillation, Paroxysmal Arrhythmia
NAVISTAR® THERMOCOOL® SF Catheter: Observational Study
This is a prospective, interventional, observational, unblinded, single-arm, multicenter registry of younger and older subjects with drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation.
- Trial name
- SFAF (NCT01585961)
- Testing
- Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)
- Where
- 45 sites in United States
- Volunteers
- 511 people
- Sponsor
- Biosense Webster, Inc.
Persistent Atrial Fibrillation
Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation
The overall objective of the study is to compare and assess the clinical outcomes of the standard of care hybrid ablation using epicardial ablation in conjunction with endocardial PVI alone versus epicardial ablation in…
- Trial name
- NCT02344394
- Testing
- Medtronic Cryoballoon, Thermocool Catheter, nContact
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation
SCAR Burden of Left Atrium Guided cathEter Ablation sTrategy for Persistent Atrial Fibrillation
This is a multicenter, randomized controlled trial to compare the recurrence of 1-year atrial arrhythmia after catheter ablation of atrial fibrillation (AF) between pulmonary vein isolation (PVI) and PVI with additional left…
- Trial name
- SCARLET-AF (NCT05794386)
- Testing
- LVA-guided LA substrate modification
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Seoul National University Hospital
Congestive Heart Failure, Atrial Fibrillation
Catheter Ablation for Atrial Fibrillation and Heart Failure
To compare heart function, symptoms, exercise capacity and quality of life in patients with Congestive Heart Failure (CHF) and Atrial Fibrillation (AF)before and after catheter ablation.
- Conditions
- Congestive Heart Failure, Atrial Fibrillation, Arrhythmia
- Trial name
- NCT01082601
- Testing
- Pulmonary Vein Isolation (PVI)
- Where
- 2 sites in United States
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Atrial Fibrillation, Quality of Life
Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)
The objective is to compare the efficacy of 2 treatment strategies, catheter ablation of atrial fibrillation versus optimized pharmacological therapy, in patients with symptomatic atrial fibrillation.
- Trial name
- CAPTAF (NCT02294955)
- Testing
- Catheterablation, Amiodarone, Sotalol
- Where
- Sweden
- Volunteers
- 152 people
- Sponsor
- Uppsala University Hospital
Atrial Fibrillation
Video-Assisted Thoracoscopic Pulmonary Vein Isolation Versus Percutaneous Catheter Ablation in Atrial Fibrillation Trial
Recent studies demonstrated that radiofrequency isolation of the pulmonary veins (PVI) and surgically video assisted thorascopic pulmonary vein isolation (VATS-PVI) are acceptable or even superior alternatives to antiarrhythmic…
- Trial name
- VATCAT (NCT01319747)
- Testing
- PVI, VATS-PVI
- Where
- Netherlands
- Volunteers
- 77 people
- Sponsor
- Medisch Spectrum Twente
Atrial Fibrillation
Safety and Effectiveness Evaluation of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation
The primary objective of this clinical investigation is to demonstrate safety and effectiveness of the Multi-Electrode RF Balloon catheter for the treatment of drug refractory symptomatic paroxysmal atrial fibrillation.
- Trial name
- STELLAR (NCT03683030)
- Testing
- Multi-Electrode RF Balloon Catheter
- Where
- 41 sites in United States, China and 1 more
- Volunteers
- 397 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Radiofrequency Catheter Ablation for Chronic Atrial Fibrillation
The purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation.
- Trial name
- NCT00272636
- Testing
- Radiofrequency catheter ablation, Amiodarone and cardioversion
- Where
- 2 sites in United States, Italy
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Atrial Fibrillation
Clinical Trial for Optimal Novel Oral Anticoagulant (NOAC) Schedule Immediate Before Catheter Ablation for Atrial Fibrillation
This study is to evaluated the interruption schedule of NOAC in patients who undergo atrial fibrillation ablation. The investigators will compare the bleeding complications were classified as major and minor bleeding…
- Trial name
- NCT02504177
- Testing
- novel oral anticoagulant for 30 days, novel oral anticoagulant for 24 hour
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Hypertrophic Cardiomyopathy
Antiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy
Paroxysmal or chronic atrial fibrillation (AF) develops in about 20- 25% of adult patients with hypertrophic cardiomyopathy (HCM) and represents an important complication in the clinical course of the disease, with adverse…
- Trial name
- NCT00821353
- Testing
- RF catheter ablation, Antiarrhythmic drugs
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Persistent Atrial Fibrillation
PFLotus With the DePolar Mapping System in Patients With Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and efficacy of pulmonary vein isolation (PVI), focal, and linear ablation in patients with persistent atrial fibrillation (PersAF) using a novel shape-adaptive pulsed field…
- Trial name
- NCT07321002
- Testing
- Ablation with the PFLotus catheter and Depolar system
- Volunteers
- 35 people
- Sponsor
- The Third People's Hospital of Chengdu
Atrial Fibrillation
Pulsed-field Ablation Vs. Sham Ablation to Treat AF
The study is planned as a single-blind, multicenter, prospective, randomized study. Sixty sbjects will be randomized 1:1 to either: (i) EP study + PFA, or (ii) EP study + Sham ablation control.
- Trial name
- NCT05717725
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF)
Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly
The WISER-AF trial is a multicenter, double-blind, sham-controlled, randomized controlled trial. It aims to evaluate the efficacy and safety of catheter ablation compared to a sham procedure in improving the quality of life…
- Trial name
- WISER-AF (NCT07403760)
- Testing
- Catheter Ablation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation
The purpose of this study is to determine if additional ablation during the first procedure as the result of the ability to medically induce quiet atrial arrhythmias will improve clinical outcome in patients with atrial…
- Trial name
- NCT03032965
- Testing
- Adenosine, Isoproterenol
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Michigan
Atrial Fibrillation (AF)
Performance After Cardiac Ablation in Endurance Athletes for Atrial Fibrillation
The relationship between exercise and atrial fibrillation (AF) seems to follow a J-shaped curve: while moderate activity reduces AF risk, both insufficient and excessive endurance exercise increase susceptibility.
- Trial name
- PACE-AF (NCT07726056)
- Testing
- Ablation
- Where
- 5 sites in Australia, Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital of Leuven Leuven
Atrial Fibrillation
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.
Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium.
- Trial name
- IDEAL-AF (NCT04377594)
- Testing
- Radio frequency ablation
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Atrial Fibrillation, Catheter Ablation
Low-Level EMF Stimulation for Paroxysmal Atrial Fibrillation
This research has two main specific aims. First, a commercially-available stimulator will be utilized to assess the effect of low-level electromagnetic field (EMF) stimulation on atrial fibrillation (AF) inducibility in patients…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Autonomic Imbalance
- Trial name
- NCT03593486
- Testing
- Low-level Pulsed EMF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation
The Effect of Short Term Amiodarone Treatment After Catheter Ablation for Atrial Fibrillation
The purpose of this study is to examine the overall effectiveness of short-time anti-arrhythmic drug treatment with amiodarone (to control heart rhythm) to prevent short-and long-term atrial fibrillation following an ablation…
- Trial name
- AMIO-CAT (NCT00826826)
- Testing
- Catheter ablation, Amiodarone
- Where
- 2 sites in Denmark
- Volunteers
- 212 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet