Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation (AF), Bleeding
Concomitant PFA Bsaed PVI Plus LAAC
A multicenter, prospective registry of concomitant Farapulse (Boston scientific) based PVI and Watchman Flx device (Boston scientific) based LAAC procedures was planned in order to assess the acute and mid-time safety, efficacy…
- Conditions
- Atrial Fibrillation (AF), Bleeding, Stroke
- Trial name
- COCONUT_2 (NCT07450755)
- Testing
- Interventional LAA Closure, Pulmonary vein isolation
- Volunteers
- 150 people
- Sponsor
- Asklepios proresearch
Atrial Fibrillation
Colchicine and CRP in Atrial Fibrillation and AF Ablation
Colchicine will lower C-reactive protein (CRP) in chronic atrial fibrillation and reduce the rise in CRP which occurs following atrial fibrillation ablation
- Trial name
- NCT01755949
- Testing
- Colchicine, 0.6 mg PO BID
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Catheter Ablation
Efficacy of Pulmonary Vein Isolation Alone in Patients With Persistent Atrial Fibrillation
This study examines non-inferiority of pulmonary vein isolation (PVI) for persistent atrial fibrillation (AF) to extensive ablation; and reveals the effect of the presence or origin of AF trigger on outcomes of catheter ablation.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Recurrence
- Trial name
- EARNEST-PVI (NCT03514693)
- Testing
- PVI, PVI plus additional ablation
- Volunteers
- 512 people
- Sponsor
- Osaka Cardiovascular Conference
Pulsed-field Ablation, Deep Sedation
Safety And FEasibility of a Simplified Deep Sedation Protocol for Pulsed-Field Ablation
The aim of the SAFE-PFA study is to demonstrate the feasibility and safety of a simplified deep-sedation protocol for pulsed-field ablation of atrial fibrillation, with a specific focus on patient-reported outcomes.
- Conditions
- Pulsed-field Ablation, Deep Sedation, Atrial Fibrillation (AF)
- Trial name
- SAFE-PFA (NCT07633548)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Sick Sinus Syndrome
PACE-AF: Prospective Analysis of Cardiac Electrostimulation and Atrial Fibrillation
PACE-AF is a prospective, observational patient registry designed to evaluate the impact of pacemaker algorithms on atrial fibrillation (AF) incidence, progression, and clinical outcomes in patients implanted with dual-chamber…
- Conditions
- Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- PACE-AF (NCT07279207)
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Ilya Lukin
Atrial Fibrillation, Thromboembolism
Investigation on Appropriate Duration of Dabigatran Use After Catheter Ablation for Paroxysmal Atrial Fibrillation in Patients With Low Thromboembolic Risk
The purpose of this study is to investigate the appropriate duration of dabigatran use after radiofrequency catheter ablation for paroxysmal atrial fibrillation in patients with low thromboembolic risk.
- Trial name
- NCT02313584
- Testing
- dabigatran
- Volunteers
- 464 people
- Sponsor
- Korea University
Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF)
A Global Randomized Trial Evaluating the FARAFLEX™ Mapping and Pulsed Field Ablation System With Electrographic Flow Mapping in Patients Undergoing Repeat Ablation for Atrial Fibrillation
The goal of the ReDEFINE-AF Clinical Study is to evaluate the safety and effectiveness of the FARAFLEX™ Mapping and Pulsed Field Ablation System with electrographic flow mapping in subjects undergoing repeat ablation for atrial…
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF), Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- ReDEFINE-AF (NCT07820930)
- Testing
- FARAFLEX Mapping and Pulsed Field Ablation System
- Volunteers
- 650 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation, Hemolysis
Hemolysis During Pulsed-field and Radiofrequency Ablation
Hemolysis during and after catheter ablation will be compared between catheter ablation performed using radiofrequency and pulsed-field energy.
- Conditions
- Atrial Fibrillation, Hemolysis, Pulsed-field Ablation
- Trial name
- NCT06096428
- Testing
- Pulsed-field ablation, Radiofrequency ablation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Atrial Fibrillation
Renal Denervation + PVI vs PVI Alone for Persistent AF
Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN).
- Trial name
- ERADICATE-AF (NCT05116384)
- Testing
- catheter ablation, renal artery denervation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Atrial Fibrillation, Atrial Arrhythmia
Clinical and Healthcare Economic OutcoMes From ReAl-worlD Use in Europe of an AI Software During AF Ablation
The goal of this Observational Prospective Multi-center Study is to observe the acute and long-term safety and performance outcomes after spatiotemporal dispersion-based AF/AT ablation utilizing the Volta Medical AI software in…
- Conditions
- Atrial Fibrillation, Atrial Arrhythmia, Arrhythmias, Cardiac
- Trial name
- COMRADE-AI (NCT06083012)
- Testing
- Cardiac mapping
- Where
- 7 sites in France, Germany
- Volunteers
- 186 people
- Sponsor
- Volta Medical
Atrial Fibrillation, Catheter Ablation
Bladder Catheters During Ablation Procedures
Inserting a Bladder catheter during catheter ablation is standard practice at most Institutions. Unfortunately, bladder catheters are associated with adverse outcomes, including catheter associated cystitis, hematuria, dysuria…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Catheter Complications
- Trial name
- NCT03635034
- Testing
- Insert bladder catheter, No catheter
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- St. Vincent Cardiovascular Research Institute
Atrial Fibrillation
Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with an increased risk of morbidity and mortality1.
- Trial name
- ISAR-AF (NCT01363895)
- Testing
- Percutaneous closure of LAA, Catheter ablation of AF
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation Recurrence
Atrial Fibrillation Recurrence Prediction
We aimed to develop an dual-branch deep learning network that integrates feature representations extracted from medical texts using large language models, with structured data features derived from perioperative records of AF…
- Trial name
- NCT06977516
- Where
- 5 sites in China
- Volunteers
- 2,508 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Atrial Fibrillation, Atrial Tachycardia
AutoMatic disPERsion Tagging Function Preliminary Evaluation
Interventional, prospective, non-randomized, single-center, non-controlled clinical investigation as part of the premarket clinical evaluation of VX1+ medical device, aiming to verify that VX1+ in bidirectional configuration with…
- Conditions
- Atrial Fibrillation, Atrial Tachycardia, Atrial Arrhythmia
- Trial name
- AMPERE (NCT05362656)
- Testing
- VX1+ dispersion mapping
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Volta Medical
Atrial Fibrillation
Catheter Ablation of Longstanding Persistent Atrial Fibrillation
This randomized prospective study compared three ablation strategies in patients with longstanding persistent atrial fibrillation (LPeAF).
- Trial name
- NCT02929836
- Testing
- PVI, LA linear ablation, CFAE ablation
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Hybrid Therapy and Heart Team for Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a prevalence ranging from 5% over 60 years old to 17% after 85 years old.
- Trial name
- HT2AF (NCT03737929)
- Testing
- Hybrid ablation, Percutaneous catheter ablation
- Where
- 3 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Toulouse
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Comparative Intra-procedural Evaluation of Farapulse and FARAWAVE Nav Catheters
The FARAPULSE PFA catheter (Boston Scientific), a first-generation Pulsed Field Ablation (PFA) tool, has demonstrated good performance in isolating pulmonary veins (PV).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Pulsed Field Ablation
- Trial name
- NCT07130773
- Testing
- Second-generation FARAWAVE Nav catheter without the use of pre-ablation CT, FARAPULSE with pre-ablation CT
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- Cardiocentro Ticino
Atrial Fibrillation, Catheter Ablation
Low-Level EMF Stimulation for Paroxysmal Atrial Fibrillation
This research has two main specific aims. First, a commercially-available stimulator will be utilized to assess the effect of low-level electromagnetic field (EMF) stimulation on atrial fibrillation (AF) inducibility in patients…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Autonomic Imbalance
- Trial name
- NCT03593486
- Testing
- Low-level Pulsed EMF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction
The objective of CABA-HFPEF is to test whether catheter ablation (CA) for atrial fibrillation (AF) can prevent adverse cardiovascular outcomes in patients with heart failure with preserved (HFpEF) or mildly reduced ejection…
- Conditions
- Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
- Trial name
- CABA-HFPEF (NCT05508256)
- Testing
- CE-marked Catheter Ablation
- Where
- Germany
- Volunteers
- 1,548 people
- Sponsor
- Charite University, Berlin, Germany