Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure
Efficacy and Safety of a Voltage-Guided Stepwise Strategy for Pulmonary Vein Isolation
The goal of this clinical trial is to learn if a voltage-guided stepwise pulmonary vein isolation (PVI) strategy can achieve effective PVI while potentially reducing lesion delivery, compared with conventional circumferential…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure, Atrial Tachyarrhythmia Recurrence, Esophageal Thermal Injury
- Trial name
- VoS-PVI (NCT07354737)
- Testing
- Radiofrequency ablation catheter system
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Ajou University School of Medicine
Persistent Atrial Fibrillation
Hybrid Characterization of Driver Sites During Atrial Fibrillation and Sinus Rhythm
The primary objective of this study is twofold, first we aim to identify rotors in atrial fibrillation (AF) and analyze their relationship with the left atrium-left atrial appendage (LA-LAA) connections.
- Trial name
- Hybrid-AFMAP (NCT05077670)
- Testing
- Pulmonary vein electrical isolation, Atrial substrate mapping
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)
Atrial Fibrillation
The Influence of Catheter Ablation for Atrial Fibrillation on Atrial Electrical
This study explored the influence of radiofrequency catheter ablation and cryoballoon ablation on atrial electrical remodeling in patients with atrial fibrillation,the relationship between atrial electrical remodeling and…
- Trial name
- NCT03322085
- Testing
- radiofrequency ablation or cryoballoon
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The Second Hospital of Hebei Medical University
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Inflammatory and Endothelial Function Response, and Arrhythmia Recurrence Following Catheter Ablation for Atrial Fibrillation
Current international guidelines recommend a three-month blanking period after pulmonary vein isolation (PVI) for atrial fibrillation (AF).
- Trial name
- NCT04269785
- Testing
- Cryoballoon ablation, Radiofrequency ablation
- Sponsor
- Karan Saraf
Atrial Fibrillation
Hybrid Versus Catheter Ablation in Persistent AF
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a lifetime risk of developing AF of 1 in 4 people aged over 40.
- Trial name
- HARTCAP-AF (NCT02441738)
- Testing
- Hybrid Ablation, Catheter Ablation
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation
Safe Use of New Oral Anticoagulants in Ablation for Atrial Fibrillation
Use of new oral anticoagulants (NOAC) in patients before and after catheter based pulmonary vein isolation (PVI) is still controversial.
- Trial name
- NCT02569255
- Testing
- Pulmonary venous ostia isolation
- Volunteers
- 234 people
- Sponsor
- Private Hospital Heart Center Varde
Persistent Atrial Fibrillation
Epicardial Approach in Recurred Atrial Fibrillation
We aimed to assess the benefit of epicardial mapping and ablation in patients with recurred atrial tachyarrhythmias after single procedure for atrial fibrillation.
- Trial name
- EPIREAF (NCT02979847)
- Testing
- hybrid approach, conventional endocardial approach
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital
Paroxysmal Atrial Fibrillation
Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation
The objective of this study is to demonstrate that the NAVI-STAR THERMO-COOL catheter can be used to safely and effectively reduce symptomatic episodes of paroxysmal atrial fibrillation in patients with frequent (>3…
- Trial name
- NCT00584415
- Testing
- GP ablation + PV isolation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation, HFpEF - Heart Failure With Preserved Ejection Fraction
Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)
To investigate whether RFCA is superior to AADs in AF patients with HFpEF on the basis of optimized anti-heart-failure drug therapy regarding their longterm clinical outcomes.
- Trial name
- NCT06125925
- Testing
- Radiofrequency catheter ablation (RFCA), Medical Therapy
- Where
- China
- Volunteers
- 436 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation
Lesion Contiguity in Very High Power-short Duration Ablation
This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR).
- Trial name
- NCT05368610
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- University of Barcelona
Atrial Fibrillation
Microfidelity (MIFI) Ablation Technology Versus Standard Ablation Catheter for Atrioventricular Nodal Ablation
The aim of our study is to investigate the comparative efficacy of high fidelity multi electrode ablation catheters vs the standard bipolar configuration in success of AV nodal ablation This study will provide insights on the use…
- Trial name
- NCT03114124
- Testing
- MIFI Catheter, Standard Ablation Catheter
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Atrial Fibrillation
Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation
The objective is to compare the progression of Atrial Fib (AF) burden by continuous monitoring in patients with recently diagnosed paroxysmal AF treated by catheter ablation (PVI) versus anti-arrhythmic drug (AAD) therapy.
- Trial name
- CABAL (NCT01505296)
- Testing
- Antiarrhythmic drug, Catheter ablation
- Where
- 2 sites in United States, Russia
- Sponsor
- Valley Health System
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Comparison of Treatment Outcomes Between Convergent Procedure and Catheter Ablation for Persistent and Longstanding Persistent Atrial Fibrillation
In the last 20 years, atrial fibrillation has become one of the leading healthcare burden in Europe and other developed countries.
- Trial name
- NCT04509180
- Testing
- Catheter ablation, Convergent procedure
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
Continuous Versus Discontinuous Design of Encircling Lesions During Ablation for Atrial Fibrillation
Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the…
- Trial name
- CDAF (NCT03332862)
- Testing
- catheter ablation
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Atrial Fibrillation
A Prospective Study of Medical Therapy Against Cryoballoon Ablation in Symptomatic Recent Onset Persistent AF
Prospective trial comparing the efficacy and safety of CryoBalloonAblation (CBA) to standardized medication for treatment of early onset persistent atrial fibrillation (AF) without structural heart disease.
- Trial name
- METACSA (NCT02389218)
- Testing
- single ablation (CryoBalloonAblation (CBA), sequential drug adjustment (propafenone, sotalol or flecainide)
- Where
- 3 sites in Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Ghent
Atrial Fibrillation
Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation
The purpose of this study is to compare the effectivity and safety of atrial fibrillation ablation, in comparison to antiarrhythmic drug therapy in patients with refractory, persistent atrial fibrillation.
- Trial name
- SARA (NCT00863213)
- Testing
- Atrial fibrillation ablation, Antiarrhythmic drug
- Where
- 8 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation (AF)
Low-VOLTage Area-Guided Catheter Ablation and SVC Isolation for Persistent Atrial Fibrillation Using a Balloon-in-Basket Pulsed Field Ablation Catheter
The primary objective of this study is to determine whether low-voltage areas (LVA)-guided catheter ablation combined with superior vena cava (SVC) isolation and pulmonary vein isolation (PVI), performed using the…
- Trial name
- LowVOLT-AF (NCT07587541)
- Testing
- Volt™ Pulsed Field Ablation System
- Volunteers
- 618 people
- Sponsor
- University of Luebeck
Paroxysmal Atrial Fibrillation
TactiCath® Prospective Effectiveness Pilot Study
EFFICAS II proposes to test the hypothesis that treatment efficacy correlates to contact force parameters applied for pulmonary vein isolation (PVI) during AF ablation.
- Trial name
- EFFICAS II (NCT02131337)
- Testing
- Electrophysiology study
- Where
- 3 sites in Czechia, Germany
- Volunteers
- 45 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Atrial Flutter
An Initial Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System
A prospective, single-arm, multi-center, safety and performance assessment of the Sphere-9™ Catheter and the Affera Mapping and Ablation System to treat Atrial Arrhythmias
- Trial name
- NCT04210622
- Testing
- Catheter mapping and ablation with the Sphere-9 Catheter and Affera Mapping and Ablation System
- Where
- Lithuania
- Volunteers
- 16 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation
VAscular Closure for Cardiac Ablation Registry (VACCAR)
The objective of this registry is to find out if there is a difference in patient satisfaction and rate of vascular and bleeding complications with use of Perclose Proglide system or F08S for venous closure post atrial…
- Trial name
- VACCAR (NCT03546439)
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Saint Luke's Health System