Clinical trials: Atrial Fibrillation Catheter Ablation
Persistent Atrial Fibrillation
Clinical Outcomes of Persistent Atrial Fibrillation Ablation Using Ablation Index-guided Radiofrequency Catheter Ablation in Patients With Continuous Monitoring
Atrial fibrillation (AF) is the commonest condition affecting the rhythm of the heart. Tablets to try to normalize the heart rhythm rarely work well.
- Trial name
- AF-FAIR-MONTOR (NCT05406310)
- Testing
- Ablation Index-guided ablation, High-power, short-duration ablation using QDOT Micro catheter
- Sponsor
- St. Louis University
Atrial Fibrillation
Pulsed-field Ablation Vs. Sham Ablation to Treat AF
The study is planned as a single-blind, multicenter, prospective, randomized study. Sixty sbjects will be randomized 1:1 to either: (i) EP study + PFA, or (ii) EP study + Sham ablation control.
- Trial name
- NCT05717725
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Persistent Atrial Fibrillation
Evaluation of a Multi-electrode Linear Type Catheter (D-1368-01-SI)
The purpose of this trial is to assess acute safety and performance of the Multi-electrode Linear Type Catheter in conjunction with generator software V2.4.0 or above when used for the treatment of Persistent Atrial Fibrillation.
- Trial name
- NCT02991313
- Testing
- Endocardial Ablation Procedure
- Volunteers
- 40 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation (AF)
Evaluation of the Effectiveness and Safety of Remote Electrocardiographic Monitoring in Patients with Atrial Fibrillation Following Ablation Therapy
Background: Atrial fibrillation (AF) is the most common arrhythmia, significantly contributing to complications such as stroke, heart failure, dementia, and increased mortality.
- Trial name
- PREEMPT-AF (NCT06751459)
- Testing
- MEMO Patch 2 - 14-day Monitoring, MEMO Patch 2 - 1-day Monitoring, MEMO Link
- Where
- 7 sites in South Korea
- Volunteers
- 270 people
- Sponsor
- HUINNO Co., Ltd
Persistent Atrial Fibrillation
Left Atrial Isolation by Catheter Ablation in Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is a single-arm clinical trial evaluating the efficacy and safety of left atrial isolation achieved by catheter ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05173779
- Testing
- Left atrial isolation by catheter ablation
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Paroxysmal Arrhythmia
NAVISTAR® THERMOCOOL® SF Catheter: Observational Study
This is a prospective, interventional, observational, unblinded, single-arm, multicenter registry of younger and older subjects with drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation.
- Trial name
- SFAF (NCT01585961)
- Testing
- Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)
- Where
- 45 sites in United States
- Volunteers
- 511 people
- Sponsor
- Biosense Webster, Inc.
Persistent Atrial Fibrillation
Comparison of Reverse Remodeling and PVI Versus CFAE and/or Linear Lesions and PVI for Persistent AF
The hypothesis of this study is that by facilitating reverse atrial remodeling with maintenance of sinus rhythm in the weeks preceding ablation makes it feasible to perform a simple pulmonary vein isolation (PVI) with results…
- Trial name
- NCT01877473
- Testing
- Ablation
- Where
- United States
- Sponsor
- Valley Health System
Vagal Nerve Stimulation, Autonomic Nervous System
Vagal Response and Cardiac Autonomic Modulation. Insides From Cryoballoon Ablation
The investigators sought to evaluate the incidence and influence of vagal response observed during cryoballoon-based pulmonary vein isolation on the cardiac autonomic nervous system (CANS) and ablation outcomes in paroxysmal…
- Conditions
- Vagal Nerve Stimulation, Autonomic Nervous System, Catheter Ablation
- Trial name
- NCT04896424
- Testing
- cryoballoon-based pulmonary veins isolation
- Volunteers
- 296 people
- Sponsor
- Pomeranian Medical University Szczecin
Atrial Fibrillation (AF), Heart Failure
Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF)
This study examines whether measuring blood pressure inside the left upper chamber of the heart during a procedure to treat an irregular heartbeat called atrial fibrillation can help identify patients who would benefit from heart…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Catheter Ablation, Guideline Implementation
- Trial name
- LAP AF-HF (NCT07594886)
- Testing
- LAP-Triggered Heart Failure Optimization Pathway
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medical College of Wisconsin
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Atrial Fibrillation
Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation
There is a need to compare the efficacy of PVI versus PVI plus catheter ablation, which includes ablation of complex fractionated atrial electrograms (CFAE) and linear lesions in the same procedure.
- Trial name
- NCT03115554
- Testing
- PVI Plus Catheter Ablation, PVI Alone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation
Efficacy of Dapagliflozin on Recurrence After Catheter Ablation for Atrial Fibrillation
This is a single-center, parallel-group, randomized, open-label trial evaluating the effect of 3-month treatment with dapagliflozin 10mg once daily on the recurrence of atrial fibrillation after catheter ablation for atrial…
- Trial name
- DARE-AF (NCT06433479)
- Testing
- Dapagliflozin 10 mg per day for 3 months after initial catheter ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Persistent Atrial Fibrillation
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative…
- Trial name
- COAST-AF (NCT02184013)
- Testing
- Catheter ablation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation
Artificial Intelligence Guided Patient Selection for Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial (AI-PAFA Trial)
Atrial fibrillation (AF) is a major cardiovascular disease with a prevalence of 1.7% of the total population in Korea, associated with 25% of ischemic stroke and 30% of heart failure, and is a major cardiovascular disease that…
- Trial name
- NCT04997824
- Testing
- Artificial Intelligence-based atrial fibrillation catheter ablation, Medical Therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Three Dimensional Navigation IntraCardiac Guidance Kit for Atrial Septal Puncture
This study aims to evaluate the safety and efficacy of a three-dimensional navigation intracardiac guidance kit to perform atrial septal puncture in patients requiring catheter ablation, which will be compared with procedures…
- Trial name
- NCT06188351
- Testing
- Three-Dimensional Navigation Atrial Septal Puncture, Conventional Atrial Septal Puncture
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Tongji Hospital
Atrial Fibrillation
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
Atrial fibrillation ablation (AF) is a standard interventional treatment for patients with symptomatic AF refractory to medical treatment.
- Trial name
- CTStrain-AF (NCT04281329)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation
Lesion Contiguity in Very High Power-short Duration Ablation
This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR).
- Trial name
- NCT05368610
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- University of Barcelona
Atrial Fibrillation (AF)
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its…
- Trial name
- POBI-PFA (NCT06929897)
- Testing
- Pulmonary Vein Isolation, Additional Left Atrial Posterior Wall Ablation, Non-PV trigger test
- Where
- South Korea
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Atrial Fibrillation
Role of Subsequent Atrial Tachycardia in Mechanisms of Persistent AF
In this study, the investigators aim to examine the prognostic role of subsequent Atrial Tachycardias (ATs) in the mechanisms of atrial fibrillation (AF).
- Trial name
- NCT01896570
- Testing
- Catheter ablation of subsequent atrial tachycardia
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Fibrillation
Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps
The 64 pole basket catheter used for the mapping procedure will be defined "atypical" sites which sustain atrial fibrillation. The ablation through the driver will lead to more rapid ablation of the atrial fibrillation.
- Trial name
- CONFIRM (NCT01581437)
- Testing
- 64 pole basket catheter
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Virginia Commonwealth University