Clinical trials: Atrophy, open to volunteers
Atrophic Gastritis
Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis
Autoimmune atrophic gastritis (AAG) is an immune-mediated disorder characterized by the loss of oxyntic glands and mucosal atrophy1.Specific autoantibodies directed to gastric parietal cells (PCA) and/or to intrinsic factors are…
- Trial name
- NH-GAA (NCT07388459)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Myopathy, Muscular Dystrophies
Muscle Health Measurements Using Electrical Impedance Myography
This study is being done to further develop a device, the mScan, to measure muscle health as compared to measurements of muscle health using MRI (magnetic resonance imaging).
- Conditions
- Myopathy, Muscular Dystrophies, Myositis, Myofibrillar Myopathy
- Trial name
- NCT07502989
- Testing
- Electrical Impedance Myography
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Steinert's Disease, Myotonic Dystrophy 1
Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease)
The study team hypothesize that non-diabetic patients with Myotonic dystrophy type I (DM1) will improve their symptoms, especially their motor deficit which is the main feature of the disease, because of the splicing defect…
- Conditions
- Steinert's Disease, Myotonic Dystrophy 1, Metformin
- Trial name
- METFORMYO (NCT05532813)
- Testing
- Treatment taken
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenia in Elderly, Sarcopenic Obesity
Comparative Analysis of Sarcopenia in Rehabilitation Outcomes Following Femoral Neck Fracture: a Study in Normal Weight and Obese Study Cohort
Impact of Obesity on Sarcopenia Prevalence and Severity in Elderly Adults Recovering from Femoral Neck Fractures: A Prospective Study Introduction Age-related muscle loss, or sarcopenia, which includes reductions in both muscle…
- Conditions
- Sarcopenia in Elderly, Sarcopenic Obesity, Frailty, Femoral Fractures
- Trial name
- NCT06705166
- Volunteers
- 300 people
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Spondyloarthritis, Axial, Fatigue
Fatigue and Skeletal Muscle Impact in Severe Axial Spondyloarthritis
Axial spondyloarthropathy (SpA) is the most common inflammatory rheumatism (1% of the general population) with important medico-economic consequences. Fatigue is a major feature of SA.
- Conditions
- Spondyloarthritis, Axial, Fatigue, Exercise Capacity
- Trial name
- Famuspa (NCT03940911)
- Testing
- Measurement of aerobic exercise on cycloergometer
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Strasbourg, France
Nutrition Status
The Impact of Preoperative Nutrition Intervention on Muscle Mass Preserve in Older Adults Undergoing Elective Surgery
Sarcopenia-the progressive loss of muscle mass and strength-is a major clinical issue, especially in surgical patients with malignancy.
- Trial name
- NCT07262034
- Where
- Thailand
- Volunteers
- 62 people
- Sponsor
- Siriraj Hospital
Myotonic Dystrophy 1
A Clinical Study of PGN-EDODM1 in People With Myotonic Dystrophy Type 1
The purpose of this study is to learn about the effects of an investigational medicine, PGN-EDODM1, to see how safe and tolerable multiple administrations of PGN-EDODM1 are for people with myotonic dystrophy type 1 (DM1) compared…
- Trial name
- FREEDOM2-DM1 (NCT06667453)
- Testing
- PGN-EDODM1
- Where
- 12 sites in Canada, New Zealand and 2 more
- Volunteers
- 24 people
- Sponsor
- PepGen Inc
Facioscapulohumeral Muscular Dystrophy, FSHD
A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD
A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)
- Conditions
- Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1
- Trial name
- FORTITUDE-3 (NCT07038200)
- Testing
- AOC-1020
- Where
- 46 sites in United States, Canada and 8 more
- Volunteers
- 200 people
- Sponsor
- Avidity Biosciences, Inc.
Gingival Recession, Mucogingival Deformity - Insufficient Keratinized Tissue
Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage
This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from…
- Trial name
- NCT07590960
- Testing
- Modified Coronally Advanced Tunnel with Connective Tissue Graft
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Kidney Transplantation, Physical Function
Online Exercise Program for Transplant Patients: A Pilot Study
Kidney transplant recipients frequently experience reduced physical function, muscle weakness, low levels of physical activity, and an increased risk of cardiovascular and metabolic complications, despite improvements in survival…
- Conditions
- Kidney Transplantation, Physical Function, Muscle Weakness Condition, Physical Activity
- Trial name
- TrasplanCEU (NCT07923188)
- Testing
- Online Therapeutic Exercise Programme, Usual Care Control Group
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cardenal Herrera University
Dry Age-related Macular Degeneration, Geographic Atrophy
A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy)
This is a Phase IIb randomized, clinical trial designed to assess the safety and efficacy of unilateral implantation of the CPCB-RPE1 implant in subjects with geographic atrophy involving the fovea.
- Trial name
- PATCH-AMD (NCT06557460)
- Testing
- Surgical implantation of the CPCB-RPE1 implant
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Regenerative Patch Technologies, LLC
Acne Scars - Atrophic
Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars
To compare the efficacy and safety of combined nanofat injection with either platelet rich fibrin or microneedling versus nanofat injection alone in the treatment of facial atrophic post acne scars.
- Trial name
- NCT07471854
- Testing
- nanofat injecion, Platelet rich fibrin, Microneedling
- Volunteers
- 42 people
- Sponsor
- Assiut University
Spinal Muscular Atrophy
Neonatal Spinal Muscular Atrophy (SMA) Screening
Parents or legal guardian of neonates who signed agreement will receive SMA screening test if their neonates are affected with SMA.
- Trial name
- SMA (NCT03217578)
- Testing
- SMA Newborn Screening
- Where
- Taiwan
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Myotonic Dystrophy Type 2, Myotonic Dystrophy Type 1
Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2
Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life.
- Trial name
- BraCE-DM2 (NCT05854433)
- Testing
- Non-interventional study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gingival Recession
Changes in Soft Tissue Thickness Following Multiple Coronally Advanced Tunnel (MCAT) vs Vestibular Incision Subperiosteal Tunnel Access (VISTA)
This randomized clinical trial will compare two surgical methods for treating multiple adjacent gingival recessions (types RT1 and RT2): the Modified Coronally Advanced Tunnel (MCAT) and the Vestibular Incision Subperiosteal…
- Trial name
- NCT07200258
- Testing
- Vestibular Incision Subperiosteal Tunnel Access (VISTA), Modified Coronally Advanced Tunnel (MCAT)
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad Complutense de Madrid
Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions
Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also…
- Conditions
- Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions, Obesity (Body Mass Index >30 kg/m2), Sarcopenia
- Trial name
- NCT07030738
- Testing
- Legume-Based High-Protein Diet + Resistance Training, Meat-Based High-Protein Diet + Resistance Training, Mixed Legume and Meat High-Protein Diet + Resistance Training
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Duchenne Muscular Dystrophy
The U.K. NorthStar Clinical Network
The goal of this natural history study is to capture the natural history of Duchenne Muscular Dystrophy (DMD) in children and adults in the United Kingdom. Children and adults with DMD will be invited to join.
- Trial name
- NS (NCT06711692)
- Where
- 26 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Geographic Atrophy
A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This study aims to evaluate the safety and efficacy of BRX011, an oral medication, taken once daily by participants with geographic atrophy secondary to age-related macular degeneration.
- Trial name
- BELLAVISTA (NCT07029945)
- Testing
- BRX011
- Where
- 17 sites in United States, Australia
- Volunteers
- 152 people
- Sponsor
- Biojiva LLC
Neurological Regression, Myoclonus
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders
Study description: This is a natural history study that will evaluate any patient with enzyme or DNA confirmed GM1 or GM2 gangliosidosis, sialidosis or galactosialidosis.
- Conditions
- Neurological Regression, Myoclonus, Cherry Red Spot, Brain Atrophy
- Trial name
- NCT00029965
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia
This study aims to investigate the effects of a 12-week multimodal exercise intervention on middle-aged and older adults (aged 45~85 years) with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT07398495
- Testing
- Multimodal Exercise Program
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- yueh chu wu
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