Clinical trials: Atypical Femur Fracture
Atypical Femur Fracture
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660…
- Trial name
- NCT04110795
- Testing
- No Intervention
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment
Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. The most common examples of these drugs are Boniva and Fosamax.
- Conditions
- Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
- Trial name
- NCT01875458
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteoporosis, Bone Diseases, Metabolic
Bisphosphonate Users Radiographic Characteristics of the Hip (BURCH) Study
Background: Osteoporosis is a condition where the bone becomes more brittle and more likely to break as a person ages. The drugs that people take to treat this condition have prevented many common hip fractures.
- Conditions
- Osteoporosis, Bone Diseases, Metabolic, Hip Fractures
- Trial name
- NCT01360099
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Atypical Femur Fracture
Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs
DXA scanners are routinely used to assess bone mineral density (BMD) and fracture risk in osteoporosis patients. They provide detailed bone imaging in a low radiation setting.
- Trial name
- NCT01747304
- Testing
- DXA Se femur scans (previously called IVA femur)
- Where
- Canada
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Osteoporosis, Knee Osteoarthristis
The Effect of Long-term Use of Bisphosphonates on Femur Morphology
Recent studies have shown that bone modeling can occur throughout life, suggesting bone has a persistent ability of adapting structure to loading.
- Trial name
- NCT06621069
- Testing
- Bisphosphonates, Control
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine