Clinical trials: Auditory Dysfunction, Central
Aging, Cognitive Decline
ACHIEVE Brain Health Follow-Up Study
The ACHIEVE Brain Health Follow-Up Study is a 3-year follow-up to the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study to determine the long-term effect of hearing intervention vs.
- Conditions
- Aging, Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- ACHIEVE-BHFU (NCT05532657)
- Testing
- Hearing intervention, Successful aging/delayed hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 629 people
- Sponsor
- Johns Hopkins University
Hearing Loss, Cochlear Hearing Loss
Peripheral and Central Influences on Auditory Temporal Processing & Speech Perception in Older Cochlear Implantees
Older adults who use cochlear implants to address hearing loss show wide variation in benefit. This research investigates the role of normal aging, the health of peripheral and central auditory pathways, and positioning of the…
- Conditions
- Hearing Loss, Cochlear Hearing Loss, Hearing Loss, Sensorineural, Aging
- Trial name
- NCT05554692
- Testing
- Diagnostic tests of cochlear implant function, Diagnostic tests of auditory function
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Maryland, College Park
Central Auditory Processing Disorder, Traumatic Brain Injury
Central Auditory Processing Disorders Associated With Blast Exposure
The incidence of central auditory dysfunction in war fighters who are exposed to high-explosive blasts while serving in combat have not been clearly determined.
- Conditions
- Central Auditory Processing Disorder, Traumatic Brain Injury, Hearing Loss
- Trial name
- NCT00554801
- Testing
- Audiological testing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Unilateral Hearing Loss
Functional Magnetic Resonance Imaging Study of the Central Auditory System After Single Sided Deafness
The objective is to study the relation between the reorganization of the central auditory system, and the psychophysical deficits in binaural hearing in subjects with single sided deafness.
- Trial name
- SSD (NCT02534298)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Migraine
Randomized Trial in Adult Participants With Acute Migraines
The purpose of this study is to test the safety and efficacy of BHV-3500 (zavegepant) versus placebo in the acute treatment of moderate or severe migraine.
- Trial name
- NCT04571060
- Testing
- Zavegepant
- Where
- 94 sites in United States
- Volunteers
- 1,978 people
- Sponsor
- Pfizer
Migraine Headaches
Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine
This is a Phase 1/ Phase 2, 12-week, multi-center, randomized, double-blind, cross-over, placebo-controlled study to evaluate the efficacy and safety of ELS-M11 compared to placebo in 50 male and female subjects, aged 18 to 65…
- Trial name
- NCT02057315
- Testing
- ELS-M11
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Achelios Therapeutics
Neuropsychological Tests, Memory
Adaptation and Normalization of a Verbal Episodic Memory Test in French Sign Language
To date, neuropsychological assessment of deaf signing persons is complicated by a lack of resources, especially the absence of tools available in French Sign Language (LSF).
- Conditions
- Neuropsychological Tests, Memory, Alzheimer Disease, Deafness
- Trial name
- RL-RI-LSF (NCT06902753)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Profound Hearing Impairment
Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation.
Our main objective is to study how the extent of reorganization of the central auditory system is related to the binaural integration in cochlear implanted subjects with asymmetric hearing loss.
- Trial name
- UniTEP (NCT03117413)
- Testing
- Positron emission tomography scan
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Dementia, Hearing Loss
Validation Of The Flemish Montreal Cognitive Assessment (MoCA) For Persons With Hearing Impairment
The Montreal Cognitive Assessment (MoCA) is a screening test for detecting cognitive impairment that assesses several cognitive domains (attention and concentration, arithmetic and orientation, memory, etc.).
- Trial name
- MoCA-HI (NCT06400173)
- Testing
- Cognitive screening, Audiological Assessment
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- University Ghent
Tinnitus
Effect of Musical Auditory Training on Subjects With Tinnitus Disorder
Among the theories of tinnitus generation, there is that of central neuroplastic changes, which reports the association between changes and reorganization that occur in central auditory pathways and impacts on associated areas…
- Trial name
- NCT06371287
- Testing
- Treinamento Auditivo Musical
- Where
- 2 sites in Brazil
- Volunteers
- 24 people
- Sponsor
- Universidade Federal de Santa Maria
Hearing Loss, Sensorineural, Bilateral Vestibulopathy
Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects
The world population has been growing and aging dramatically, with a rising prevalence of dementia. Worldwide, around 50 million people have dementia, with 10 million new cases added every year.
- Conditions
- Hearing Loss, Sensorineural, Bilateral Vestibulopathy, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- GECkO (NCT04385225)
- Testing
- Longitudinal follow-up
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Dementia, Hearing Loss
Hearing Impairment as a Risk Factor for Dementia in Older Adults
This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby…
- Trial name
- NCT04284384
- Where
- Norway
- Volunteers
- 6,952 people, healthy volunteers welcome
- Sponsor
- Norwegian Centre for Ageing and Health
Hearing Loss, Bilateral (Causes Other Than Tumors)
New Approach to Objectively Measure Social Engagement in Older Adults With Hearing Loss
The goal of this clinical trial is to learn if hearing devices, like hearing aids, affect social and cognitive function of older adults.
- Trial name
- NCT06781749
- Testing
- Hearing aid use
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Stent Stenosis, Intracranial Hypertension
Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis
This is a prospective, randomized, single-center clinical study aiming to explore the safety and efficacy of venous stenting for patients with internal jugular vein stenosis (IJVS).
- Conditions
- Stent Stenosis, Intracranial Hypertension, Headache, Tinnitus
- Trial name
- NCT03373292
- Testing
- Venous stenting for internal jugular vein stenosis, One-month routine medical treatment followed by venous stenting for internal jugular vein stenosis
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI
Auditory Stimulation During Sleep to Enhance Long-Term Memory in Amnestic MCI
This study aims to evaluate the efficacy and safety of Elevvo AudiStim, a sleep auditory stimulation device, as a symptomatic treatment for patients with amnestic mild cognitive impairment (aMCI).
- Conditions
- Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI, Alzheimer or Mild Cognitive Impairment
- Trial name
- NCT07402590
- Testing
- Auditory Stimulation
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Bitbrain
Hearing Loss, Hearing Loss, Noise-Induced
Understanding the Consequences of Recreational Noise Exposure
The aim of this study is to determine whether measures derived from Magnetic Resonance Imaging (MRI) scans, and clinical and behavioural measures of hearing loss, in the peripheral and central auditory system (ranging from the…
- Trial name
- NCT05076344
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson's Disease, Mild Cognitive Impairment
Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training
People with Parkinson's disease are at higher risk of cognitive decline, and current treatments cannot fully prevent this. This study explores non-drug ways to support brain function.
- Trial name
- PDCogTSleep (NCT07441915)
- Testing
- Phase-Targeted Auditory Stimulation (PTAS), Digital Cognitive Training (CogT)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center