Clinical trials: Augmentation
Major Depressive Disorder
Efficacy of SEROQUEL in Selective Serotonin Reuptake Inhibitors (SSRI)-Resistant Major Depressive Disorder
An open-label, non-comparative, multi-centre, phase II prospective trial to assess the efficacy of Quetiapine fumarate augmentation of selective serotonin reuptake inhibitors (SSRIs) in SSRI-resistant major depressive disorder.
- Trial name
- UNIQUE (NCT00733668)
- Testing
- Quetiapine fumarate (Seroquel)
- Where
- 4 sites in Belgium
- Sponsor
- AstraZeneca
Failure of Dental Implant Due to Lack of Attached Gingiva
Gingival Augmentation Around Implants During Maintenance
This prospective controlled randomized blind clinical study investigated 44 implants displaying lack of KG in 29 subjects. Fourteen subjects received FGGs followed by oral prophylaxis.
- Trial name
- NCT02904551
- Testing
- Free gingival graft, Oral prophylaxis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bone Resorption
Vertical Augmentation Using Onlay Versus Inlay Autogenous Graft With Simultaneous Implant Placement.
Using autogenous Chin block for vertical augmentation with simultaneous implant placement at anterior maxilla region comparing between the Onlay and Inlay grafting techniques.
- Trial name
- NCT03052387
- Testing
- assigned intervention
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sleep Deprivation
fMRI-behavioral Study of Cholinergic Augmentation With Donepezil in Healthy Sleep Deprived Adults
The purpose of this study was to characterize how the anti-cholinesterase inhibitor (AChE-I) donepezil modulates brain regions involved in visual short-term memory, episodic memory and inhibitory efficiency following 24 hours of…
- Trial name
- NCT00800553
- Testing
- donepezil
- Where
- Singapore
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Correction of Volume Loss in the Infraorbital Hollow Area
A Pilot Study to Assess the Effectiveness and Safety of Belotero Balance® Injection for Volume Augmentation of the Infraorbital Hollow
The pilot study aims to define safety, effectiveness, and patient-reported outcomes for Belotero Balance® use in the infraorbital hollows.
- Trial name
- NCT03777917
- Testing
- Belotero Balance®
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Merz North America, Inc.
Stroke, Brain Injuries
Safety and Efficacy Evaluation of the Robotic Enhanced Error Training of Upper Limb Function in Post-stroke and Post TBI Participants
Background: Cerebrovascular accident [CVA or commonly known as stroke] and traumatic brain injury (TBI) are common causes of morbidity, and motor impairments.
- Conditions
- Stroke, Brain Injuries, Paresis, Cerebrovascular Disorders
- Trial name
- NCT06010823
- Testing
- PlaXtreme
- Where
- 2 sites in Israel
- Volunteers
- 96 people
- Sponsor
- Reuth Rehabilitation Hospital
Bone Defects
Endoscopic-Assisted Versus Conventional Crestal Sinus Lift
To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
- Trial name
- sinus lift (NCT07824037)
- Testing
- Endoscopic-guided Sinus lift, non- endoscopic sinus lift
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Nahla Mahmoud Awad
Implant Site Reaction
the Peri-implant Tissue Changes Around Implants in the Esthetic Zone Using Demineralized Dentin Graft vs Xenograft
Dentin grafts are categorized into mineralized dentin, partially demineralized dentin matrix (PDDM), and demineralized dentin matrix (DDM).
- Trial name
- NCT06164353
- Testing
- Partially demineralized dentin graft covered with a collagen membrane
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Shoulder Injuries
Subscapularis Repair Augmentation for Total Shoulder Arthroplasty
The primary purpose of this research is to compare the images obtained by ultrasound between a standard repair of the subscapularis tissue and after repair with a Biobrace.
- Trial name
- NCT05487677
- Testing
- BioBrace Augmentation, Standard Repair with Sutures
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Bone Resorption
State of the Art Immediate Implant Placement in the Premaxilla
The goal of this clinical study is to learn how well immediate implant placement works in the front upper jaw (premaxilla) when using flapless guided surgery, hard and soft tissue augmentation, and immediate provisional crowns.
- Trial name
- NCT07080710
- Testing
- Immediate implant placement
- Where
- 2 sites in Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Ghent
Horizontal Ridge Deficiency
The Horizontal Ridge Augmentation Using Equine Xenograft and a Collagenated Porcine Cortical Lamina
The primary aim of this study is to clinically, radiographically and histologically evaluate the lateral bone augmentation of the soft porcine cortical lamina (OsteoBiol®) using equine-derived bone particles (OsteoBiol®)
- Trial name
- NCT04376060
- Testing
- Gen-Os®; The soft lamina (OsteoBiol®)
- Where
- Lebanon
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Lip; Anomaly
THIODERM ELATE for Volume Augmentation in Lips
A pivotal, randomized, subject- and evaluator-blinded, controlled, non-inferiority, multicenter, parallel group comparison study to evaluate effectiveness and safety of THIODERM ELATE for lip augmentation in order to correct lip…
- Trial name
- TIVOLI (NCT06133153)
- Testing
- THIODERM ELATE, Juvéderm Ultra 3
- Where
- Austria
- Sponsor
- Croma-Pharma GmbH
Long COVID Symptoms
Vagal Approaches on Long COVID-19
The purpose of this study is to explore whether two general wellness products, alone or combined, can support individuals experiencing Long COVID symptoms.
- Trial name
- NCT07190105
- Testing
- Sonocea Sonic Augmentation Technology (SAT), Truvaga Electrical Vagus Nerve Stimulator
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- Leidos Life Sciences
Dental Implants, Sinus Floor Augmentation
Osteotome Sinus Floor Elevation With or Without Grafting
The osteotome sinus floor elevation (OSFE) technique has been proved to be a predictable procedure for successful implant placement in posterior maxillae with limited bone height under sinus.
- Conditions
- Dental Implants, Sinus Floor Augmentation, Bone Remodeling
- Trial name
- NCT01619956
- Testing
- SLA dental implants, Osteotome sinus floor elevation, Bone grafting
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Tooth Extraction, Tooth Replacement
Comparison of Two Collagen Membranes for Bone Augmentation Around Dental Implants Restored with Monolithic Zirconia Single Crowns
The goal of this randomized controlled clinical trial is to compare the use of two covering collagen membranes in a bone augmentation procedure around single implants and to assess three different veneering approaches on crowns…
- Trial name
- BioGide-Compr (NCT06724783)
- Testing
- Collagen membrane
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- Dr. med. dent. Malin Strasding
Schizophrenia, Negative Symptoms
Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia
Negative symptoms and cognitive dysfunction in schizophrenia (CDS) are core features of schizophrenia. These negative symptoms and cognitive deficits have a devastating impact on the function, employment, and social interactions…
- Conditions
- Schizophrenia, Negative Symptoms, Cognitive Dysfunction
- Trial name
- NCT01488929
- Testing
- TC-5619
- Where
- 64 sites in United States, Hungary and 4 more
- Volunteers
- 603 people
- Sponsor
- Targacept Inc.
Smoking Cessation
Progesterone Augmentation of Nicotine Replacement Therapy Study
This will be a double-blind, placebo-controlled, pilot, randomized clinical trial. A total of 50 women who smoke and have regular menstrual cycles will be randomized to either progesterone (200 mgs BID) + Transdermal Nicotine…
- Trial name
- PANS (NCT02685072)
- Testing
- Progesterone (200 mgs BID)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Yale University
Schizophrenia, Schizophreniform Disorder
Pregnenolone Augmentation in the Treatment of Patients With Recent-Onset Schizophrenia
Pregnenolone (PREG) is a neurosteroid, which displays multiple effects on the central nervous system, and may be beneficial in the treatment of patients with schizophrenia.
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorders
- Trial name
- PREG-2008 (NCT00847600)
- Testing
- Pregnenolone
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Emphysema, Alpha 1-proteinase Inhibitor Deficiency
Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.
This study is a continuation of the placebo-controlled study CE1226_4001 (NCT00261833) to evaluate the efficacy and safety of Zemaira® intravenous (i.v).
- Trial name
- NCT00670007
- Testing
- Alpha1- proteinase inhibitor [human]
- Where
- 21 sites in Australia, Canada and 9 more
- Volunteers
- 140 people
- Sponsor
- CSL Behring
Alveolar Bone Loss
Three-Dimensional Printed Customized Titanium Mesh for Mandibular Augmentation
Completely or partially edentulous patients suffer from resorption of the alveolar bone, they always seek rehabilitation which becomes challenging.
- Trial name
- NCT05198011
- Testing
- 3D customized Titanium Mesh (Study), Conventional ridge augmentation (Control)
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Hams Hamed Abdelrahman