Clinical trials: Autism
Broad Autism Phenotype
Physical Exercise Training to Enhance Executive and Social Functions
Background and study aims: Executive functions (EF) and social functions are important for self-regulation, problem solving, and attaining future goals yet they are impaired in Autism Spectrum Disorder (ASD).
- Trial name
- NCT04896671
- Testing
- Physical exercise (running on a treadmill)
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tuberous Sclerosis, Autism Disorder
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive…
- Conditions
- Tuberous Sclerosis, Autism Disorder, Intellectual Disability
- Trial name
- NCT02461459
- Where
- 6 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Play and Playthings
Evaluation and Development of Playing Skills for Parents With Children With Special Needs
Children with special needs; experiences physical, behavioral, social, cognitive and emotional limitations. These limitations affect the child's play skills.
- Trial name
- NCT05757115
- Testing
- Play Skills Training
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Autism Spectrum Disorder (ASD)
Coaching and Leadership in Autism Support Settings
Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based practices: 1) an intervention gap characterized by limited availability of evidence-based practices…
- Trial name
- CLASS (NCT07276750)
- Testing
- RUBIES, HELM, Educator Psychoeducation
- Where
- United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Autism Spectrum Disorder
Affective Prosody Recognition and Auditory Intervention for Children With Autism Spectrum Disorders (ASD)
The proposed study aims to examine the abilities of children with ASD to recognize emotional tones of voice - also known as affective prosody - as compared to typically developing (TD) children.
- Trial name
- NCT04427150
- Testing
- Auditory Training, Non-auditory training
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Borderline Personality Disorder, BPD
Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Social cognition impairment is critical to the pathology and morbidity of a number of psychiatric disorders, including the schizophrenia spectrum, the autism spectrum and the personality disorders, thus representing a dimension…
- Conditions
- Borderline Personality Disorder, BPD, Schizotypal Personality Disorder, SPD
- Trial name
- NCT02149823
- Testing
- Syntocinon 24 Intranasal Units (IU), Syntocinon 40 Intranasal Units (IU)
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Maria de las Mercedes Perez Rodriguez
Autism Spectrum Disorder, Sibling Relations
Psychoeducation for Adult Siblings of ASD People (Autism Spectrum Disorder).
The purpose of this study was to evaluate the effectiveness of a novel psychoeducational program for adult siblings of autistic individuals, aiming to improve autism-related knowledge, well-being, resilience and sibling…
- Trial name
- NCT06361147
- Testing
- Psychoeducational program for ASD
- Where
- Greece
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Hellenic Mediterranean University
Sexual Health, Education, Health
Health Education and Relationships Through Theater: An RCT of Promoting Awareness Through Live Movement and Sound for Youth With Autism Spectrum Disorder (PALMS-ASD)
Teens with ASD ages 14-19 will be screened for eligibility, complete a baseline interviewer/ACASI-administered survey, and randomly assigned to either intervention or control group. The enrollment goal is 500 teens.
- Trial name
- HEART (NCT04005547)
- Testing
- Promoting Awareness through Live Movement and Sound for youth with Autism Spectrum Disorder
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Public Health Management Corporation
Autism Spectrum Disorder
Fit Families Program for Families of Children With Autism Spectrum Disorder
The purpose of the study is twofold. First, to identify the effect of a 12-week fundamental motor skills (FMS) (e.g., throwing, catching, running) intervention on the active participation in physical recreation activities as well…
- Trial name
- NCT05159102
- Testing
- 12-week FMS Intervention, Physical Activities & Activity Booklets (via FitFamilies app)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism Spectrum Disorder
Improving ToM in Children With ASD Through VPT Training: Behavioral and fNIRS Study
This study aims to employ a longitudinal tracking research to investigate the effects of a visual perspective taking intervention on the development of theory of mind in children with autism.
- Trial name
- NCT06196060
- Testing
- Visual perspective taking training, Block building training, Thought-bubble training
- Where
- 3 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing Normal University
Autism Spectrum Disorders, Autism
Identification of Characteristics Associated With Symptom Remission in Autism
Autism is defined as a lifelong pervasive developmental disability, as such, symptom recovery is considered rare. Reports by Lovaas and McEachin, Smith \& Lovaas and more recently by Cohen, Amerine-Dickens, \& Smith, Smith Groen…
- Trial name
- NCT00938054
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Asperger's Disorder, High-functioning Autism
Adolescent Social Skills Training Program
This study is a pre-test, post-test single group design with follow-up at month three. Twenty-four individuals total will participate in this study with 6 participants in each of 4 cohorts.
- Trial name
- ASST (NCT01031823)
- Testing
- Multi-Media Social Skills Training Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Autism Spectrum Disorder
Development and Validation of a System for the Anticipation of Challenging Behaviors
Most people with autism spectrum disorder (ASD) present at least one form of challenging behavior (CB). Self-injurious, aggressive, and disruptive CBs linked with social interaction, community-based service exclusion, and a life…
- Trial name
- NCT05340608
- Testing
- Smart, non-invasive shirt - Physiological parameters, Smart, non-invasive shirt - Relation with challenging behaviors, Smart, non-invasive shirt - Proof of Concept
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ariel University
Williams Beuren Syndrome, Williams Syndrome
Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants
The goal of this observational natural history study is to better characterize development, transition to adulthood, health and behavior of individuals diagnosed with Williams syndrome (WS) or carrying other variants of 7q11.23…
- Conditions
- Williams Beuren Syndrome, Williams Syndrome, Williams Beuren Region Duplication, Dup7
- Trial name
- NCT06930417
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder, Neurodevelopmental Disorders
School-based Paraeducator Education for Engagement at Recess
The purpose of the proposed three-site study is to test whether an educator-level implementation strategy, coaching, with or without a school-level implementation strategy, school-based teams, will maximize paraeducators' use…
- Trial name
- SPEER (NCT06559267)
- Testing
- Remaking Recess, TEAM
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Washington
Autism Spectrum Disorder, Adverse Childhood Experiences
Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition
Using a metabolomics approach in combination with eye-tracking data, this research study proposes to gather evidence from two interrelated body systems (gut and brain) in order to assess how the microbiome is involved in stress…
- Conditions
- Autism Spectrum Disorder, Adverse Childhood Experiences, Stress Reaction
- Trial name
- NCT06269614
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Biospecimen Donation, Brain Injury
University of Central Florida CereBank
Millions of persons are affected by brain diseases. The CereBank will be used to support research studies aimed at improving the diagnosis and treatment of brain diseases.
- Conditions
- Biospecimen Donation, Brain Injury, Brain Diseases
- Trial name
- NCT06876857
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Autism Spectrum Disorder, Asperger Disorder
Understanding the Effects of Intervention on the Brain in Autism
This study examines how the PEERS (Laugeson \& Frankel, 2010; Laugeson, 2016) social-behavioral intervention affects social relationships and brain development and function in autistic preschoolers, adolescents, and young adults.
- Conditions
- Autism Spectrum Disorder, Asperger Disorder, PDD-NOS, Autism
- Trial name
- NCT02680015
- Testing
- PEERS
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Marquette University
Autism Spectrum Disorder, Autism
Advocating for Supports to Improve Service Transitions
This is a randomized intervention study to develop and test the national curriculum of a parent intervention training targeting parent's ability for advocate for services to improve the transition to adulthood for their youth…
- Trial name
- ASSIST (NCT04173663)
- Testing
- ASSIST
- Where
- 3 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Food Selectivity
Healthy Eating ASD
Most studies which have addressed food selectivity among children with autism spectrum disorders have been conducted in either clinic or home settings.
- Trial name
- NCT04075552
- Testing
- Pre Meal Presentation, Pre Meal Presentation + Modeling, Pre Meal Presentation + Token Economy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Penn State University