Clinical trials: Autobiographical Memory, active
Alzheimer Disease, Early Onset, Atypical Alzheimer's Disease
Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease
Alzheimer's disease (AD) is the leading neurodegenerative disease of aging characterized by multiple cognitive impairments. Given the recent failures of disease-modifying drugs, the current focus is on preventing or mitigating…
- Conditions
- Alzheimer Disease, Early Onset, Atypical Alzheimer's Disease, Logopenic Progressive Aphasia
- Trial name
- NCT04122001
- Testing
- Active, in-person HD-tDCS or active remote tDCS, Word List Learning Intervention (WordLLI)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Behavior
Neural Mechanisms for Reducing Interference During Episodic Memory Formation
Healthy individuals from the University of Oregon and surrounding community will be recruited for participation in behavioral, fMRI and eye tracking experiments that investigate human memory.
- Trial name
- NCT05092100
- Testing
- Visual stimulus similarity, fMRI, Eye tracking
- Where
- United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Episodic Memory
Posterior Cingulate Cortex and Executive Control of Episodic Memory
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior.
- Trial name
- NCT06540976
- Testing
- Cognitive testing
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pennsylvania
Autobiographical Memory, Function of the Human Hippocampus
fMRI Studies of Memory and Perception
Episodic memory allows us to project ourselves back in time to mentally re-experience the past in vivid detail. This remarkable feat helps to define our personal identities and enables context-appropriate predictions that guide…
- Trial name
- NCT07860281
- Testing
- Participants use a smartphone to replay self-generated autobiographical memory cues.
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Florida State University
Epilepsy Intractable
Neuronal Mechanisms of Human Episodic Memory
The purpose the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, and making decisions or choices about presented information.
- Trial name
- NCT04500119
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Epilepsy, Autobiographical Memory
Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings
The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted…
- Trial name
- CAPTURE (NCT06883981)
- Testing
- Free and Cued Recall Memory. Temporal Sequence and Spatial Memory
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Generalized Anxiety, Fear of Failure
Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence
This pilot randomized controlled trial will investigate the feasibility and effectiveness of using generative artificial intelligence to create personalized therapeutic scripts for imagery rescripting (ImRs).
- Conditions
- Generalized Anxiety, Fear of Failure, Rumination
- Trial name
- FRBN (NCT07189715)
- Testing
- Imagery Rescripting Intervention (AI-Generated)
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Epilepsy Intractable
Memory Retrieval and Encoding Investigated by Neural Stimulation
The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain…
- Trial name
- MEMREINS (NCT04286776)
- Testing
- Direct electrical stimulation
- Where
- 11 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Pennsylvania
Huntington Disease, Autobiographical Memory
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressively worsening motor, cognitive, psychiatric, and behavioral deficits.
- Trial name
- MAMOC-MH (NCT07409597)
- Testing
- neuropsychological tests, Eye tracker use
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Healthy Aging, Cognition
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
This pilot study aims to investigate the effects of a single oral dose of cannabidiol (CBD) on memory and attention in healthy adults aged 60 to 70 years.
- Trial name
- CBD-MAP (NCT07910292)
- Testing
- Cannabidiol (CBD)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment
Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with AMCI
Mild Cognitive Impairment (MCI) is a condition in which patients show an objective evidence of impairment in one or more cognitive domains but a spared independence in daily functional abilities.
- Conditions
- Mild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment, Neurodegenerative Dementia, Neurodegenerative Disease
- Trial name
- NCT06755164
- Testing
- Simultaneous aerobic and cognitive training (SIM), Sequential aerobic and cognitive training (SEQ)
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Down Syndrome, Intellectual Disability
Escalating Doses of Memantine in Down Syndrome (MEDS-123)
Down syndrome (DS) is typically caused by an extra chromosome 21 in the cell nucleus (trisomy 21, or T21). T21 is both the most common cause of genetically defined intellectual disability and the earliest documented cause of…
- Conditions
- Down Syndrome, Intellectual Disability, Alzheimer Dementia (AD)
- Trial name
- NCT07531940
- Testing
- Memantine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Memory Replay, HippoCamera
A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome
Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory.
- Trial name
- NCT07008989
- Testing
- Memory replay
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston College
Motivation
InformationSeekingMesolimbicEngagementStudy2
Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.
- Trial name
- NCT06257433
- Testing
- Task Instructions
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Temple University
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Aging
Older Age and Generalization
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults.
- Trial name
- NCT07440017
- Testing
- Memory decision type
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Caitlin Bowman
Multiple Sclerosis, Memory
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple…
- Conditions
- Multiple Sclerosis, Memory, Learning
- Trial name
- E-SEP (NCT04694534)
- Testing
- Serious game, Usual HAS care
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Lille Catholic University
Psilocybin, Music Intervention
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
The goal of this clinical trial is to understand how personally meaningful, autobiographically salient music compares to standardized playlists when combined with psilocybin in healthy adults ages 21 to 75.
- Trial name
- PRoMiSS (NCT07180108)
- Testing
- Psilocybin (high dose), Playlist 1, Playlist 2
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Generalized Anxiety, Fear of Failure
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs).
- Conditions
- Generalized Anxiety, Fear of Failure, Rumination
- Trial name
- ImRs_LLM_DeanG (NCT07565714)
- Testing
- Imagery Rescripting Intervention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw