Clinical trials: Autoimmune
Fatigue in Multiple Sclerosis, Multiple Sclerosis
Fatigue in Multiple Sclerosis and Its Relationship to Inflammatory and Neurodegenerative Markers of the Disease
The study is focused on several independent quantifiable biomarkers (sNfL, sGFAP, mitochondrial activity, genetics and fatigue tests) to obtain more detailed information about MS and its progression.
- Conditions
- Fatigue in Multiple Sclerosis, Multiple Sclerosis, Neurofilaments Light Chains, GFAP
- Trial name
- MITOFATIGUE (NCT07025122)
- Where
- Slovakia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Rheumatoid Arthritis, Healthy Controls
MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
Persons with rheumatoid arthritis (RA) suffer from increased disability and mortality, in part resulting from skeletal muscle impairments.
- Trial name
- MusculRA (NCT04226131)
- Testing
- Blood Draw, Disease Activity (DAS-28) Assessment, Skeletal Muscle Mitochondrial Respiratory Capacity
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Mucocutaneous Candidiasis, Invasive Aspergillosis
Natural History of Individuals With Immune System Problems That Lead to Fungal Infections
Background: The immune system is made up of special cells, tissues, and organs that fight infections. Problems with this system may lead to frequent, severe, or unusual fungal infections.
- Conditions
- Chronic Mucocutaneous Candidiasis, Invasive Aspergillosis, CARD9, APECED
- Trial name
- NCT01386437
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Glucose-stimulated Pancreatic Islet and Intestinal Blood Flow in Healthy Subjects and in Type 1 Diabetes
Type 1 diabetes is the major type of diabetes in the young. The pathophysiology still needs clarification in order to reach feasible means of preventing the disease.
- Trial name
- ISLET-PET (NCT02547337)
- Where
- Finland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Effects of Teriflunomide (Aubagio) on Cognitive and Vocational Outcomes in Multiple Sclerosis
Cognitive impairment is common in MS and has devastating impact on functional activities. There is a great demand for medications that will enhance cognitive capacity in MS patients.
- Trial name
- NCT02651545
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Multiple Sclerosis, Mitochondrial Alteration
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients.
- Trial name
- MS-MIDY (NCT03052595)
- Testing
- Oral glucose tolerance test, Testing of autonomous nervous system function, Stroop test
- Where
- Slovakia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Autoimmune Diseases
Phase I Study of GSK2982772 in Japanese Healthy Male Participants
The study plans to enroll approximately 12 subjects. The main objective of the study is to assess the safety, tolerability and pharmacokinetics (PK) of the three times a day (TID), dosing of GSK2982772, in Japanese healthy male…
- Trial name
- NCT03590613
- Testing
- GSK2982772
- Where
- Japan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes Mellitus
Implantable Antenna Sensors for Continuous Glucose Monitoring
The researchers' long-term goal is to develop a small implantable device that can continually monitor glucose levels. This will be an antenna.
- Trial name
- NCT00596323
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Volunteers, Rheumatoid Arthritis
A Study of Intravenous CPTX2309 in Healthy Participants and Participants With Moderate to Severe Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE)
The purpose of this study is to assess the safety and tolerability of CPTX2309 in healthy adult participants and adult participants with moderate to severe rheumatoid arthritis or systemic lupus erythematosus.
- Conditions
- Healthy Volunteers, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT06917742
- Testing
- CPTX2309
- Where
- 3 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Capstan Therapeutics
Autoimmune Diseases, Inflammatory Diseases
Effect of BMS-986165 on the Pharmacokinetics of Rosuvastatin
The study is to assess the effect of coadministration of multiple doses of BMS-986165 on the systemic exposure of rosuvastatin in healthy participants.
- Trial name
- NCT03044873
- Testing
- BMS-986165, Rosuvastatin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Plasmablast/Plasma Cells in Diagnosis of IgG4-RD, Plasmablast/Plasma Cells in Relapse Prediction of IgG4-RD
Circulating Plasmablast in Diagnosis and Relapse Prediction of IgG4-RD
300 IgG4-RD patients, 200 other autoimmune diseases, 60 IgG4-RD mimickers and 100 healthy controls were enrolled. Circulating plasmablast/plasma cells were detected of all patients at baseline and healthy controls.
- Trial name
- NCT04539197
- Where
- China
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Dementia, Motor Neuron Disease
Digital App for Speech & Health Monitoring
Many people living with neurodegenerative conditions like dementia, motor neuron disease (MND), multiple sclerosis (MS), and Parkinson's disease (PD), suffer from speech problems.
- Conditions
- Dementia, Motor Neuron Disease, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT06450418
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Systemic Lupus Erythematosus (Sle)
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Study Description: Systemic lupus erythematosus (SLE) occurs predominantly in women and is driven by type I interferon dysregulation and neutrophil hyperresponsiveness.
- Trial name
- NCT06032923
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Graves Disease
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
Patients with GD often present with glucose dysregulation, which, according to most studies, is associated with islet β-cell dysfunctions, enhanced gluconeogenesis and insulin resistance (IR).
- Trial name
- NCT02376088
- Testing
- Methimazole
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Weikai Hou
Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis
Serum Neurofilaments and GFAP in Atypical Multiple Sclerosis
Idiopathic inflammatory disorders of the central nervous system include various disorders of which multiple sclerosis is the most common.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis, Controls, Multiple Sclerosis
- Trial name
- AMIS (NCT04201470)
- Testing
- Blood withdrawal, MRI, Neurologic / neuropsychologic tests - Patients
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Phase Ⅰ Clinical Trial of Gerilimzumab Injection in Healthy Subjects
The primary objectives of this study are to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of single-dose, dose-escalated, abdominal subcutaneous injection of GB224 in Chinese healthy adult subjects.
- Trial name
- NCT04178070
- Testing
- GB224 2mg, GB224 5mg, GB224 10mg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Diabetes Mellitus, Type 1, Diabetes Complications
PeRsOnalising Treatment Of Diabetic Nephropathy:
Background: Today diabetic nephropathy is a frequent, and the most lethal and costly complication of diabetes. Although treating blood pressure with agents blocking renin angiotensin system has improved outcome, the prognosis is…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Complications, Diabetic Nephropathies
- Trial name
- PROTON (NCT03509454)
- Where
- Denmark
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Peter Rossing
Rheumatoid Arthritis
Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients
The purpose of this study is to determine if the use of sub-cutaneous (SC) abatacept provides any structural benefit in patients with rheumatoid arthritis who have failed prior use of TNF therapy.
- Trial name
- NCT01351480
- Testing
- abatacept
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Arthritis & Rheumatic Disease Specialties Research
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