Clinical trials: Autoimmune
Autoimmune Bullous Dermatosis
Coagulopathy of Immunodermatologic Diseases
This study will examine the coagulation and fibrinolysis profiles of those with autoimmune skin diseases. Blood samples will be collected from participants with active/poorly controlled immune-mediated skin diseases and…
- Trial name
- NCT06037187
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Marathon, Physical Activity
Glycemic Control Before, During and After the 2016 Paris Marathon
This is an observational mono-centric retrospective study carried out at the University Hospital of Brest The main objective of this study is to assess the glycemic control before, during and after the 2016 Paris Marathon in…
- Conditions
- Marathon, Physical Activity, Type 1 Diabetes Mellitus, Education
- Trial name
- MARADIAB (NCT04926298)
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Multiple Sclerosis
The Effects of FES in a Variety of Walking Conditions in People With MS
The aim of this study is to measure the difference in the walking performance when functional electrical stimulation (FES) is on and off in people with MS that present foot drop under different 'real life' conditions, i.e.
- Trial name
- NCT03410498
- Testing
- Incremental shuttle walk test
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Rheumatoid Arthritis
Rheumatology Clinical Registry
The ACR Rheumatology Clinical Registry (RCR) is a tool developed to assist members in practice improvement, local population management, and efficient, successful participation in national quality programs.
- Trial name
- RCR (NCT01813409)
- Where
- United States
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- American College of Rheumatology
Type 1 Diabetes Mellitus
Type 1 Diabetes Prediction and Prevention (DIPP) Study
The Type 1 Diabetes Prediction and Prevention (DIPP) Study in Finland is a population-based long-term clinical follow-up study established since 1994 in three university hospitals in Finland to understand the pathogenesis of type…
- Trial name
- DIPP (NCT03269084)
- Testing
- No intervention. DIPP is an observational study.
- Where
- 3 sites in Finland
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- Riitta Veijola
Type 1 Diabetes, Celiac Disease
Combined Antibody Screening for Celiac and Diabetes Evaluation
The CASCADE Study (Combined Antibody Screening for Celiac and Diabetes Evaluation) is an observational study whose primary goal is to show that population-based screening for advanced prediction of type 1 diabetes (T1D) and…
- Trial name
- CASCADE (NCT04677699)
- Testing
- Combined Risk Score
- Where
- United States
- Volunteers
- 64,410 people, healthy volunteers welcome
- Sponsor
- Pacific Northwest Research Institute
Hypoxia, Diabetes Mellitus, Type 1
Studies on the Adaptive Responses to Hypoxia
The general aim of this study is to define the response to hypoxic challenge in patients with diabetes. The investigation will provide response for different questions that are central for explaining the development of…
- Trial name
- HYKRAND (NCT02629406)
- Testing
- Hypoxia
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Multiple Sclerosis, Pregnancy
Exercise and Pregnancy in People With Multiple Sclerosis
The purpose of this study is to examine acute physiological responses to exercise and activity patterns of people with multiple sclerosis (MS) during pregnancy and postpartum.
- Trial name
- NCT05313204
- Testing
- Moderate-intensity cardiovascular exercise
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 1 Diabetes
Lipoprotein Kinetics in T1D
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke).
- Trial name
- LTD (NCT05179954)
- Testing
- Metabolic testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Multiple Sclerosis
Proprioceptive Neuromuscular Facilitation in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune central nervous system disease characterized by inflammation, demyelination, and axonal degeneration.
- Trial name
- NCT05342025
- Testing
- PNF, Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biruni University
Multiple Sclerosis
Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease.
- Trial name
- ITEMS (NCT02518776)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Type 1 Diabetes
Liraglutide in Type 1 Diabetes
The glucose lowering effects of GLP-1 agonists are well established in subjects with type 2 diabetes, however, these have not been studied prospectively in subjects with type 1 diabetes.
- Trial name
- 1966 (NCT01722240)
- Testing
- Liraglutide 1.8mg
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Multiple Sclerosis
Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult Participants
This is a randomized, placebo-controlled, four-part, Phase I, first in human (FIH) study to assess the tolerability and pharmacokinetics (PK) of ascending single and 14-day repeated oral doses of SAR442168 with a food effect…
- Trial name
- NCT06106074
- Testing
- Tolebrutinib
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sanofi
Neurologic Disorder, Parkinson Disease
High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive.
- Conditions
- Neurologic Disorder, Parkinson Disease, Spinal Cord Injuries, Spina Bifida
- Trial name
- SHIFT-AR (NCT05951985)
- Testing
- HIFT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Multiple Sclerosis, Healthy
Immune Profiling During Ocrelizumab Treatment in Multiple Sclerosis
The purpose of this study is to assess effects of B cell depletion on the immune system in patients with relapsing forms of multiple sclerosis (MS) treated with ocrelizumab.
- Trial name
- NCT03138525
- Testing
- Blood sampling (MS), Blood sampling (controls)
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ART5803 following IVIG administration in healthy participants to investigate the potential interactions between ART5803 and IVIG
- Conditions
- Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder), Autoimmune Encephalitis
- Trial name
- NCT06753955
- Testing
- ART5803, Intravenous immunoglobulin (IVIG)
- Where
- Australia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Arialys Therapeutics
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1
TrialNet Pathway to Prevention of T1D
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00097292
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Diabetes Mellitus, Type 1
Performance of Continuous Glucose Monitoring Systems at Altitude
10 healthy volunteers will undergo the controlled lowering of their blood glucose level at sea level and a simulated altitude of 8,000 feet, to test the hypothesis that continuous glucose monitoring system measurement of blood…
- Trial name
- NCT01223651
- Testing
- two step hyperinsulinaemic glucose clamp study.
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Royal Bournemouth Hospital
Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
This study will look at the blood and cerebrospinal fluid of consented participants who either have early stage multiple sclerosis (clinically isolated syndrome) or who have later stage (secondary progressive multiple sclerosis)…
- Conditions
- Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Clinically Isolated Syndrome
- Trial name
- NCT01737372
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- John F. Foley, MD
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