Clinical trials: Autoimmune
Immune Thrombocytopenia, Thrombocytopathy
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
- Conditions
- Immune Thrombocytopenia, Thrombocytopathy, Acute Leukemia, Hemorrhagic Disorders
- Trial name
- NCT05654766
- Testing
- Flow cytometry, Platelet aggregation and plasma coagulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Type 1 Diabetes
Anti-diabetic Effects of Liraglutide in Adolescents and Young Subjects With Type 1 Diabetes
This is the first prospective randomized double-blind placebo-controlled study to investigate the effect of a GLP-1 analog, specifically liraglutide, on blood glucose levels and variability in subjects with type 1 diabetes…
- Trial name
- NCT01722227
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University at Buffalo
Type 1 Diabetes Mellitus
Detection of Human Beta Cell Death in Type 1 Diabetes Mellitus (T1DM) by Methylation Specific Polymerase Chain Reaction (PCR)
To investigate the use of methylation-specific PCR (MSP) assays to detect human beta cell-specific gene methylation patterns in serial blood samples drawn from newly diagnosed Type 1 diabetics.
- Trial name
- NCT01176253
- Testing
- Blood draw
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes Mellitus, Exercise Physiology
Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise
This study evaluates a clinician-facing decision-support toolkit designed to assist adults with type 1 diabetes in preparing for moderate-intensity exercise.
- Trial name
- NEXT (NCT07226583)
- Testing
- Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Arthritis, Rheumatoid
Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease
Given the cost and risk associated with biologic disease modifying anti-rheumatic drugs (bDMARDs), selection of the optimal medication is imperative.
- Trial name
- NCT02742337
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arthritis Northwest PLLC
Rheumatoid Arthritis
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects synovial joints, leading to pain, swelling, and progressive joint damage. Early diagnosis is critical to prevent irreversible disability.
- Trial name
- Anti-pcolce/RA (NCT07129837)
- Testing
- Clinical evaluation, disease activity and disability scoring, and laboratory testing including RF, anti-CCP, and serum anti-PCOLCE antibody measurement by ELISA.
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Graves Ophthalmopathy
Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.
This study is a randomized, controlled, multi-center clinical study, the purpose is to evaluate the efficacy and safety of rapamycin combined with methylprednisolone in the treatment of moderate to severe active GO.
- Trial name
- NCT05532072
- Testing
- Rapamycin, Methylprednisolone
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Multiple Sclerosis
Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis
This study will evaluate a new brain MRI technique called ENRAGED FLAIR in patients with multiple sclerosis. MRI is central in the diagnosis and follow-up of multiple sclerosis because it can show inflammatory lesions in the…
- Trial name
- ENRAGED FLAIR (NCT07687693)
- Testing
- ENRAGED FLAIR MRI
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Systemic Lupus Erythematosus
Genetic Study of Lupus Patients and Their Families
The purpose of this study is to perform genetic testing in and to collect information from families affected by lupus in order to identify the genetic factors associated with systemic lupus erythematosus (SLE).
- Trial name
- NCT00235378
- Where
- United States
- Volunteers
- 2,356 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Arthritis, Rheumatoid
Evaluation of the Intestinal Microbiota and Bacterial Translocation in Patients With Rheumatoid Arthritis
The main objective of this study is to compare the intestinal microbiota in newly diagnosed rheumatoid arthritis (RA) with that from individuals without RA.
- Trial name
- MICROPOLY (NCT01961310)
- Testing
- Plasma analysis for bacterial translocation, Stool analysis
- Where
- 3 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Type 1 Diabetes
Children's Mercy Teens With Type 1 Diabetes Will Participate in an Online Peer Support Group.
The goal of this observational study is to examine the impact of an online peer support group in Children's Mercy teens with Type 1 Diabetes.
- Trial name
- NCT06412146
- Testing
- Peer Support Group
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Rheumatoid Arthritis
ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
Adenocorticotrophic Hormone provides safe and effective treatment to induce disease remission in rheumatoid arthritis patients with active disease due to an inadequate response to methotrexate.
- Trial name
- NCT01984268
- Testing
- ACTHAR
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Multiple Sclerosis
Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization…
- Trial name
- NCT00006060
- Testing
- standard gadolinium contrast
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Rheumatoid Arthritis
A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates
The study is being conducted to assess the effect of BMS-986142 on the single-dose PK parameters of montelukast, flurbiprofen, omeprazole, midazolam, and digoxin, probe drugs for (cytochome P450) CYP2C8, CYP2C9, CYP2C19, CYP3A4…
- Trial name
- NCT02762123
- Testing
- BMS-986142 200mg, BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin), BMS-986142 350mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Celiac Disease, Autoimmune Enteropathy
Pathogenic Study of Adult Immune Enteropathies
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced…
- Conditions
- Celiac Disease, Autoimmune Enteropathy, Inflammatory Bowel Diseases
- Trial name
- ENTEROPATH (NCT04280510)
- Testing
- Blood sample collection; gastrointestinal biopsy
- Where
- 4 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Ige Responsiveness, Atopic
Effect of Vegetation in Kindergartens on the Immune Response of Children
This study evaluates the effect of vegetation cover on certain Interleukin-10 and immunoglobulinE (IgE) among children (3-5 y old).
- Trial name
- ADELEWP1t7 (NCT02733926)
- Testing
- Adding of vegetation into the backyards of kindergarten
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Lupus Nephritis
Anti-alpha-actinin Antibodies and Lupus Nephritis Activity
Lupus nephritis (LN) develops in 30-60% of systemic lupus erythematosus (SLE) patients and remains a leading cause of morbidity, with 10-30% progressing to end-stage renal disease within 15 years.
- Trial name
- NCT07505576
- Testing
- renal biopsy, serum anti-alpha-actinin antibodies, CBC, serum creatinine and urea, estimated GFR, ESR, CRP, urine analysis, ANA, anti dsDNA, C3 & C4, serum albumin, 24-hrs urinary protein, and U. ACR
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus, Type 1
Testing an Integrated Care Model Trial
This study aims to test the use of an adapted collaborative care model for improving the health outcomes of adults diagnosed with type 1 diabetes (T1D). The duration of the study is 18 months with 4 study survey points.
- Trial name
- NCT06448429
- Testing
- Usual care, Collaborative care model (CoCM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Rheumatoid Arthritis
ALX-0061 Phase I Bioavailability Study in Healthy Volunteers
The overall aims of the study are: To assess the bioavailability of single doses of ALX-0061, administered s.c. at three dose levels, using 2 corresponding single i.v. dose levels as reference.
- Trial name
- NCT02101073
- Testing
- ALX-0061
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ablynx, a Sanofi company
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