Clinical trials: Autoimmune
Infections, Papillomavirus
Cervarix Long-term Safety Surveillance
This study aims to assess whether the use of Cervarix® is associated with a modified risk of central demyelination, type 1 diabetes (DT1), Cutaneous Lupus, inflammatory arthritis, idiopathic thrombocytopenic purpura (ITP), Lupus…
- Trial name
- PGRx (NCT01498627)
- Testing
- Cervarix, Data collection
- Volunteers
- 2,945 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
Consortium of Early Arthritis Cohorts USA
Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis. In the US, it is estimated that as many as 3 million adults may suffer from the disease.
- Trial name
- CATCH-US (NCT02386527)
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Sjogren's Syndrome
Comprehensive Evaluation of Clinical and Biopsychosocial Characteristics in Primary Sjögren's Disease
Following the guidance of individuals with primary Sjögren's Syndrome who receive diagnosis, routine medical care, and treatment management, the evaluations will be performed once by the researchers and will take approximately…
- Trial name
- NCT06410742
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Graves' Orbitopathy, Graves' Disease
Microbiota and Immune SignatureS of Graves' Disease and Orbitopathy
Graves' disease (GD) is the commonest cause of hyperthyroidism, characterised by anti-thyrotropin receptor autoantibodies (TRAb) persistently stimulating the thyroid gland.
- Conditions
- Graves' Orbitopathy, Graves' Disease, Graves' Ophthalmopathy, Basedow Disease
- Trial name
- MISS:GO (NCT07870161)
- Testing
- Aspiration 0
- Where
- Italy
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Type 2 Diabetes, Type 1 Diabetes
European, Open-label, Prospective, Multinational, Multicenter Study in Adult Subjects With Type 1 or Type 2 Diabetes Previously on MDI or CSII Therapy. Subjects Home Setting is Considered Routine Practice.
Accu-Chek® Insight Insulin Pump EU Study is a Multicenter Study to evaluate the Accu-Chek® Insight Insulin Pump in routine practice.
- Trial name
- NCT02105103
- Testing
- Accu-Chek® Insight Insulin Pump
- Where
- 8 sites in Austria, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
Biomechanical Characterization of the Locomotion in Multiple Sclerosis Patients
Multiple sclerosis (MS) is an inflammatory chronic disease of the central nervous system. Patients are suffering from balance and gait impairments at the early stage of the disease.
- Trial name
- WALKING-SEP (NCT03756142)
- Testing
- Motion Analysis
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Hyperthyroidism, Autoimmune, Cardiovascular Abnormalities
Clinical Application of Al18F-NOTA-FAPI-04 PET/CT or PET/MRI Imaging in Malignant Tumor,Cardiovascular or Immune Disease
This prospective, single-center study investigates the biodistribution, dosimetry, safety, diagnostic performance of Al18F-NOTA-FAPI PET imaging in patients with malignant tumor,cardiovascular or immune disease.
- Conditions
- Hyperthyroidism, Autoimmune, Cardiovascular Abnormalities, Malignant Tumor
- Trial name
- NCT07400224
- Testing
- Al18F-NOTA-FAPI PET/CT(or PET/MRI)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Autoimmune
Study of JANX011 in Healthy Adult Volunteers to Assess Safety and Tolerability.
This first-in-human (FIH) study aims to characterize the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of JANX011 dosed subcutaneously (and potentially intravenously) in healthy adult volunteers (HVs) to…
- Trial name
- NCT07291323
- Testing
- JANX011
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Janux Therapeutics
Fatigue, Walking, Difficulty
Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS
Transcutaneous Electrical Nerve Stimulation (TENS) is a treatment that could potentially reduce walking problems and fatigue in persons with Multiple Sclerosis.
- Conditions
- Fatigue, Walking, Difficulty, Multiple Sclerosis
- Trial name
- NCT06432686
- Testing
- Transcutaneous Electrical Nerve Stimulation, Movement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Healthy Volunteers
Safety Study of Immune System Modulator for Autoimmune Diseases
The purpose of this study is to determine the toxicity, tolerability and safety of single ascending doses of AX-024.HCl in healthy male subjects.
- Trial name
- NCT02243683
- Testing
- AX-024.HCl
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Artax Biopharma Inc
Multiple Sclerosis, Relapsing-Remitting
Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI
The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS).
- Trial name
- NCT04448977
- Testing
- Ocrevus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Dry Needling for Treating Spasticity in Multiple Sclerosis
The aim of the study is to evaluate the efficacy of dry needling (DN) in the treatment of spasticity in patients with multiple sclerosis (MS).
- Trial name
- NCT05351957
- Testing
- Dry needling
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Canarias
Systemic Lupus Erythematosus
The Role of ITGAM in Systemic Lupus Erythematosus
Study to examine the role of ITGAM molecule in normal control subjects with known genetic variation in the ITGAM gene.
- Trial name
- NCT01230112
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Type 1 Diabetes, Hand Skills
Comparison of Manual Skills, Visual-Motor Integration and Participation of Children With and Without Type 1 Diabetes
The aim of this study is to compare visual-motor integration, academic achievement and participation in activities of daily living with and without type 1 diabetes.
- Conditions
- Type 1 Diabetes, Hand Skills, Visual Motor Integration, Participation
- Trial name
- NCT04866212
- Testing
- Beery- Buktenica Developmental Test of Visual Motor Integration, Jebsen Taylor Hand Function Test, Participation and Environment Measure - Children and Youth
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Rheumatoid Arthritis
Development of a Normative Database for Rheumatoid Arthritis (RA) Imaging With Tc99m Tilmanocept
This study will establish a normative database of Tilmanocept Uptake Values (TUVjoint) in healthy controls age-matched to the RA population.
- Trial name
- NCT04947137
- Testing
- Tc99m tilmanocept
- Where
- 7 sites in United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Navidea Biopharmaceuticals
Multiple Sclerosis, Relapse
Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714
Ocrelizumab is a humanized anti-CD20 monoclonal antibody that showed in phase III trials a powerful effect on relapse rate and lesion load accumulation in the relapsing form of multiple sclerosis (RMS).
- Conditions
- Multiple Sclerosis, Relapse, Primary Progressive Multiple Sclerosis
- Trial name
- INN-MS (NCT03691077)
- Testing
- Ocrelizumab
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postprandial Lipid Metabolism, Type 1 Diabetes (T1D)
The TiMeD-T1D Project
The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes.
- Trial name
- NCT07172672
- Testing
- 400 mL Fresubin Energy Drink and 100 mL heavy cream with the addition of the 18F-FTHA radiotracer
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Physical Therapy
Respiratory Functions, Trunk Control and Mobility Evaluation in Multiple Sclerosis
Respiratory functions and body control are affected in patients with multiple sclerosis (MS). Because of this effect, the dependency of individuals increases in daily living activities and their quality of life decreases.
- Trial name
- NCT03826095
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Multiple Sclerosis
A Multi-Site Trial of MS INFoRm (Fatigue Management Resource)
People with MS commonly experience extreme fatigue that negatively impacts their ability to engage in a full range of daily activities, quality of life, and employment.
- Trial name
- NCT03362541
- Testing
- MS INFoRm, Usual Care Control Group
- Where
- 3 sites in Canada
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Dr. Marcia Finlayson
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