Clinical trials: Autoimmune
Multiple Sclerosis
Detection of Pattern of Some Unusual Signs and Symptoms of Multiple Sclerosis
Each Multiple Sclerosis patient will be submitted to Cognitive Abilities Screening Instrument (CASI), Expanded Disability Status Scale, Epowrth Sleeping Scale(ESS),Fatigue Severity Scale(FSS), Hamilton Depression Rating Scale…
- Trial name
- NCT04100343
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Systemic Lupus Erythematosus, Healthy Participants
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants to Study Electrocardiogram Effects
This is a study to investigate the experimental medication BMS-986165 in healthy participants in order to study the effects it has on electrocardiogram results.
- Trial name
- NCT03541564
- Testing
- BMS-986165, Moxifloxacin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
Feasibility of Non-invasive Glucose Monitoring by Using Photothermal Deflectometry
This study aims to evaluate the feasibility of non-invasive glucose monitoring by using photothermal deflectometry in the interstitial fluid of the skin on the wrist of subjects with diabetes mellitus type 1 and 2.
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus Type 1, Healthy
- Trial name
- NCT06088615
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Diamontech AG
Diabetes Mellitus, Type 1, Diabetes Mellitus
Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes
Diabetes mellitus is a common chronic disease with a huge socioeconomic burden worldwide. Type 1 Diabetes(T1D) accounts for nearly 95% of diabetes in pediatric age and a lifelong dependence on exogenous insulin.
- Trial name
- EvsBioDiabetes (NCT06832215)
- Testing
- Blood and urine samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Diet Habit, Type I Diabetes
How Type I Diabetes Responds to Different Diets (Normoglucidic or Ketogenic) During Physical Activity at Altitude
To date, no study has shown the effects of diets (normoglucidic or ketogenic) on type I diabetes during physical activity (hiking, ski touring) at altitude.
- Conditions
- Diet Habit, Type I Diabetes, Activity, Motor, Control
- Trial name
- DIAREAL (NCT06242548)
- Testing
- physical activity outings in the mountains at a level already practised by the subjects, while maintaining their usual diet (normoglucidic or ketogenic)
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Autoimmune Uveitis, Behçet Disease
Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and after therapy in uveitis…
- Conditions
- Autoimmune Uveitis, Behçet Disease, Vogt-Koyanagi-Harada Disease, Idiopathic Uveitis
- Trial name
- NCT04126850
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Systemic Lupus Erythematosus, BAFF Polymorphism
BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE
This project is intended to identify the routes on which BAFF and APRIL act in order to detect possible future candidates to Belimumab treatment among patients diagnosed of SLE.
- Trial name
- BAFF (NCT03919643)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Lupus Erythematosus, Systemic
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is…
- Trial name
- NCT00008749
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy, Guillain-Barré Syndrome (GBS)
Multispectral Optoacoustic Imaging for the Detection of Inflammation and Damage of Peripheral Nerves in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy
The aim of this study is to assess disease activity in patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Guillain-Barré Syndrome (GBS) using multispectral optoacoustic tomography (MSOT).
- Trial name
- MIND (NCT07121985)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Caffeine and Carbohydrate, Carbohydrate Only
Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 Diabetes
This project will aim to investigate the clinical efficacy and metabolic effects of a pre-exercise dose of caffeine with a low (10g) dose of carbohydrate (CAF+lowCHO) without modification of insulin degludec on exercise…
- Conditions
- Caffeine and Carbohydrate, Carbohydrate Only, Placebo
- Trial name
- DE-CAF (NCT04671043)
- Testing
- Caffeine and glucose, Glucose alone
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Relapsing-remitting Multiple Sclerosis
A Phase 1 Study to Explore the Cardiac Pharmacodynamics of MT-1303
The purpose of this study is to explore the cardiac pharmacodynamics, safety and tolerability of MT-1303 in healthy subjects.
- Trial name
- NCT02193217
- Testing
- MT-1303-Low, MT-1303-High, Fingolimod
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma Corporation
Systemic Lupus Erythematosus, Rheumatoid Arthritis
A Phase I Study of ICP-022 in Healthy Subjects
This is a single center, randomized, double-blind, placebo-controlled, dose escalation study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ICP-022 following oral single and…
- Trial name
- NCT03189017
- Testing
- ICP-022
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Innocare Pharma Australia Pty Ltd
Autoimmune Diseases
Increasing Plasma Adrenaline Levels Through Breathing Techniques - an Explorative Study
Inflammatory cytokines play a pivotal role in rheumatoid arthritis (RA) and innovative non-pharmacological therapies aimed at limiting cytokine production are highly warranted.
- Trial name
- INADRI (NCT02417155)
- Testing
- Hyper/hypoventilation, Strength ventilation
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (Apeced), Alopecia Areata
Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata
Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune system makes a mistake and attacks the body.
- Trial name
- NCT05398809
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Spinal Cord Injuries, Transverse Myelitis
The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury
The aim of this study is to evaluate the therapeutic benefits of a 10-week online coach-guided EEWP on psychosocial health among adults with SCI.
- Trial name
- NCT06147258
- Testing
- expressive writing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes Mellitus, Coronary Artery Disease
Isometric Handgrip Exercise -MRI in Children and Adolescents
This project aims to assess coronary vessel response to isometric handgrip exercise (IHE) during magnetic resonance imaging (MRI) in children with T1D children and healthy controls.
- Trial name
- NCT03506711
- Testing
- Isometric Handgrip Exercise during magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Multiple Sclerosis, NMO Spectrum Disorder
National, Multicentric Registry Study on Neuroimmunological Diseases in China
The aim of this study is to establish a real-world clinical neuroimmune disease research cohort, to follow up and observe the prognosis of patients with different subtypes and subgroups, and to provide support for the treatment…
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Myasthenia Gravis
- Trial name
- NIDBase (NCT06443333)
- Testing
- Data collection and follow-up observation, Data collection
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Severe Asthma
3TR Asthma Biologics Cohort (ABC) Study
The 3TR-ABC study is a multicentre observational prospective cohort study platform that follows patients with severe asthma from the start of biological therapy and three years onwards.
- Trial name
- 3TR-ABC (NCT06126692)
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Juvenile Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis Research Registry
Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare.
- Trial name
- NCT00090571
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
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