Clinical trials: Autoimmune / Connective Tissue Diseases
Rheumatoid Arthritis
A Study of Mavrilimumab in Subjects With Moderate-to-Severe Rheumatoid Arthritis
The primary objective of this study is to evaluate the efficacy of 3 subcutaneous doses of mavrilimumab compared with placebo in combination with methotrexate (MTX) in subjects with moderate-to-severe adult onset Rheumatoid…
- Trial name
- NCT01706926
- Testing
- Mavrilimumab 30 mg, Mavrilimumab 100 mg, Mavrilimumab 150 mg
- Where
- 42 sites in Argentina, Bulgaria and 12 more
- Volunteers
- 420 people
- Sponsor
- MedImmune LLC
Rheumatoid Arthritis
Rheumatoid Arthritis Disease Activity and Sub Clinical Atherosclerosis
RA is associated with traditional cerebrovascular risk factors as subclinical atherosclerosis. Chronic inflammation and high disease activity are associated with atherosclerotic burden, higher incidence of cerebrovascular disease…
- Trial name
- NCT03821090
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Participants
Pilot Assessment of the Safety of a Combination of Curcumin, Omega-3, and Vitamin D Supplements in ACPA+ Individuals
The goal of this clinical trial is to determine if the level of Anti-cyclic citrullinated peptide antibody (ACPA) is altered after taking curcumin, omega-3, and vitamin D supplements (COD) for 3 months.
- Trial name
- PASCOD3 (NCT06478290)
- Testing
- curcumin, omega-3, and vitamin D (COD)
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Sjögren's Syndrome
Efficacy and Safety of Belimumab in Primary Sjögren's Syndrome
Background and rationale Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lachrymal glands, frequently accompanied by systemic symptoms.
- Trial name
- NCT01008982
- Testing
- LimphoStat-B
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Udine
Osteoarthritis, Arthritis, Rheumatoid
Safety and Efficacy of Mobic Inj. (Meloxicam) for the Patients With OA or RA: Observational Study
The main objective of this PMS study was to monitor and assess the safety of Mobic® intramuscular injection (7.5mg ~ 15mg, q.d.) up to 3 days (in case of need for prolonged treatment, switch to Mobic® capsule therapy was…
- Trial name
- NCT00612885
- Where
- 11 sites in South Korea
- Volunteers
- 425 people
- Sponsor
- Boehringer Ingelheim
Systemic Lupus Erythematosus, Healthy Volunteers
Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 (Litifilimab) in Healthy Volunteers and Participants With Systemic Lupus Erythematosus
The primary objective of Parts 1 and 2 is to evaluate the safety and tolerability of either single-ascending intravenous (IV) doses or a single subcutaneous (SC) dose of BIIB059 (litifilimab) in healthy volunteers (HV), and a…
- Trial name
- NCT02106897
- Testing
- BIIB059 (litifilimab)
- Where
- 5 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Biogen
Bullous Pemphigoid, Pruritus
Explore the Mechanisms of Pruritus in Bullous Pemphigoid Patients During Remission
The following is the investigators hypothesis regarding the pruritus of BP patients during remission. Anti-BP 180 IgE binds to dermal mast cells, inducing their activation and secretion of mediators after being cross-linked by…
- Trial name
- NCT01265082
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Rheumatoid Arthritis
A Study of LY2127399 in Rheumatoid Arthritis
This study will investigate how LY2127399 works in participants with rheumatoid arthritis (RA) who are not adequately responding to methotrexate.
- Trial name
- NCT01576549
- Testing
- LY2127399
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
Enhancing Patient Ability to Understand and Utilize Complex Information Concerning Medication Self-management
The aim of the proposed project is to compare the effectiveness of two strategies designed to enhance patient understanding of medication risks/benefits: (1) Medication Guides, mandated for many medications by the Food and Drug…
- Trial name
- NCT02820038
- Testing
- Medication Guides, SMART Program, Drug Facts Boxes
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- University of North Carolina, Chapel Hill
Rheumatoid Arthritis
Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Switch to Infliximab After Incomplete Response to Etanercept
The purpose of this study, in patients with rheumatoid arthritis who have had an incomplete response to etanercept and methotrexate (MTX), are to evaluate: safety and evidence of therapeutic benefit of infliximab and…
- Trial name
- NCT00317538
- Testing
- infliximab, etanercept
- Volunteers
- 28 people
- Sponsor
- Centocor Ortho Biotech Services, L.L.C.
Rheumatoid Arthritis
Mobile Medically Supervised Patient Management in Rheumatoid Arthritis
The purpose of this study is to evaluate the use, usability and feasibility of an Application (App) for patients with rheumatoid arthritis with diary functionalities, in patient-physician interaction.
- Trial name
- MiDEAR (NCT02565225)
- Testing
- RheumaLive App use
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Giant Cell Arteritis, Acute Phase
Study of Circulating Microparticles in Giant Cell Arteritis
To demonstrate that microparticles (MPs), having a powerful procoagulant potential, are in larger amounts in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex…
- Trial name
- MicroGiant (NCT02333708)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Juvenile Idiopathic Arthritis, Inflammatory Bowel Diseases
Transition to Adulthood Through Coaching and Empowerment
Pediatric patients with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease who are preparing to transition into adult care face many unique challenges, and, to date, there is no comprehensive and implementable model of…
- Trial name
- TRACE (NCT05570617)
- Testing
- Transition Coach Intervention, Standard of Care- Youth Transition Roadmap
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
Rheumatoid Arthritis (RA)
Impact of Optimised Protein Intake on Household Work Limitations and Disability in Rheumatoid Arthritis
The goal of this clinical trial is to learn if optimised protein intake improves household work capacity and overall functional status in women with rheumatoid arthritis.
- Trial name
- NCT07737119
- Testing
- Protein Optimisation through Dietary Counselling and Supplementation
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Satguru Partap Singh Hospitals
Still's Disease, Adult-Onset
Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of APB-R3
This will be a single centre, Phase 1, First-In-Human, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Dose of APB-R3 in Healthy…
- Trial name
- NCT05715736
- Testing
- APB-R3
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Syneos Health
Systemic Lupus Erythematosus
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease…
- Trial name
- PHOENYCS GO (NCT04294667)
- Testing
- DZP
- Where
- 177 sites in United States, Argentina and 23 more
- Volunteers
- 321 people
- Sponsor
- UCB Biopharma SRL
Rheumatoid Arthritis
An Extension Study of WA19926 of the Long-Term Safety of Tocilizumab (RoActemra/Actemra) in Patients With Early Moderate to Severe Rheumatoid Arthritis
This open-label, single arm, multicenter long-term extension study of WA19926 evaluated the safety and efficacy of tocilizumab (RoActemra/Actemra) in participants with moderate to severe rheumatoid arthritis who completed the…
- Trial name
- NCT01664598
- Testing
- Tocilizumab
- Where
- 12 sites in Russia
- Volunteers
- 49 people
- Sponsor
- Hoffmann-La Roche
Fibromyalgia, Lupus Erythematosus, Systemic
Brief Pain Exposure Therapy (BPET) For Nociplastic Pain
This study is intended to test whether a brief Zoom-based behavioral treatment can help adults with fibromyalgia (FM), Lupus, chronic pelvic pain, and chronic low back pain learn effective strategies for reducing pain, disability…
- Conditions
- Fibromyalgia, Lupus Erythematosus, Systemic, Chronic Pelvic Pain, Chronic Low Back Pain (CLBP)
- Trial name
- BPET (NCT06208514)
- Testing
- Brief pain exposure therapy (BPET)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Systemic Lupus Erythematosus
Practice of Treat-to-target on Pediatric Systemic Lupus Erythematosus: a Two-center Retrospective Study
Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease activity…
- Trial name
- NCT04942314
- Volunteers
- 600 people
- Sponsor
- Jia Deng
Rheumatoid Arthritis
Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants
This Phase IIIb/IV, two-arm, randomized, double-blind, placebo-controlled, parallel-group, international, multicenter trial compares the change in disease activity (as assessed by Disease Activity Score in 28 joints [DAS28]…
- Trial name
- NCT02573012
- Testing
- Prednisone, Tocilizumab
- Where
- 39 sites in France, Germany and 4 more
- Volunteers
- 314 people
- Sponsor
- Hoffmann-La Roche