Clinical trials: Autoimmune / Connective Tissue Diseases
Giant Cell Arteritis
A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)
To investigate the safety and efficacy of abatacept with steroid treatment in comparison to steroid treatment alone in up to a 28 week taper of steroid treatment to sustain remission of Giant Cell Arteritis in adults.
- Trial name
- NCT03192969
- Testing
- Abatacept, Glucocorticoid Treatment
- Where
- 99 sites in United States, Australia and 19 more
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis
- Trial name
- NCT07171983
- Testing
- BMS-986454
- Where
- 9 sites in India
- Volunteers
- 46 people
- Sponsor
- Bristol-Myers Squibb
Arthritis, Rheumatoid
Phase IIIB Switching From Intravenous to Subcutaneous Study
The purpose of this study is to determine whether switching to subcutaneous administration of abatacept will be safe in participants with rheumatoid arthritis who previously received long-term therapy with intravenous abatacept
- Trial name
- NCT00663702
- Testing
- Abatacept
- Where
- 30 sites in United States, Canada and 1 more
- Volunteers
- 123 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Effect of a High-fat Meal on the Pharmacokinetics of SHR0302 and Mass Balance Study in Healthy Subjects
The purpose of this open-label, randomized, two-period, two-treatment (single doses of 10 mg SHR0302 fasted or fed), crossover study was to evaluate the effect of a high-fat meal on the pharmacokinetics of SHR0302 and mass…
- Trial name
- NCT02892370
- Testing
- SHR0302
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Dry Eye Syndromes, Sjögren Syndrome
Comparison Between Rebamipide 2% Versus Autologous Serum
Two-period, controlled, randomized and open clinical trial. The sample was composed of adult women with moderate to severe hypo secretory dry eye associated with Sjögren's syndrome, who attended the ocular surface office, derived…
- Trial name
- NCT03608761
- Testing
- Rebamipide, autologous serum, autologous serum and rebamipide 2%
- Where
- Argentina
- Volunteers
- 21 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Rheumatoid Arthritis
Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk
This is a small exploratory, randomized, controlled trial. Twenty-six older (ages 60-80 yr.), obese (BMI 28-40 kg/m2) persons with rheumatoid arthritis (RA) (seropositive or erosive) will be randomized to 16 weeks of a counseling…
- Trial name
- SWET/CHAT (NCT04356183)
- Testing
- SWET: Supervised Weight loss and Exercise Training, CHAT: Counseling Health As Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Rheumatoid Arthritis (RA)
A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
The primary objective of this study is to demonstrate superior efficacy of abatacept 125mg administrated SC weekly comparing to placebo after 24 weeks treatment in Chinese subjects who have active rheumatoid arthritis, are…
- Trial name
- NCT02722694
- Testing
- Subcutaneous(SC) Abatacept, Methotrexate
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Rheumatoid Arthritis
Diagnostic Value of Oral Prednisolone Test for Rheumatoid Arthritis
Rheumatoid arthritis is an inflammatory joint disease often leading to progressive joint destruction. To prevent disability caused by inflamed joints early diagnosis is important.
- Trial name
- TryCort (NCT01395251)
- Testing
- Prednisolone
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Rheumazentrum Ruhrgebiet
Systemic Lupus Erythematosus, Autoimmune Disorder
Modelling and Control of Non-invasive Vagus Nerve Stimulation for Autoimmune Diseases (1A)
The overall goal of this clinical trial is to evaluate the causality relationship between the non vagus nerve stimulation waveform parameters and the therapeutic effect.
- Conditions
- Systemic Lupus Erythematosus, Autoimmune Disorder, Vagus Nerve Autonomic Disorder
- Trial name
- VaNeSA (NCT05704153)
- Testing
- Parasym 1Hz, Parasym 30Hz
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Clinic of Barcelona
Lupus Erythematosus, Systemic, Lupus Erythematosus
Trial of Belimumab in Early Lupus
This two year study will evaluate the effects of giving belimumab (Benlysta) to patients with Early Lupus. Early lupus is a diagnosis of lupus within 2 years.
- Trial name
- NCT03543839
- Testing
- Belimumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Rheumatoid Arthritis, Psoriatic Arthritis
Mindfulness Based Stress Reduction in Rheumatic Diseases
This study will assess the mental health and clinical benefits of Mindfulness Based Stress Reduction (MBSR) in patients with rheumatic disease who have anxiety or depression.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Scleroderma
- Trial name
- MBSR (NCT03411057)
- Testing
- Mindfulness Based Stress Reduction (MBSR), Control
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Rheumatoid Arthritis
An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis
The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis (RA) who have an inadequate response or intolerance to tumor necrosis…
- Trial name
- dRAvite-LTE (NCT07620392)
- Testing
- Afimkibart
- Where
- 12 sites in United States, Brazil and 1 more
- Volunteers
- 120 people
- Sponsor
- Hoffmann-La Roche
Moderate to Severe Rheumatoid Arthritis
A Study to Assess the Efficacy and Safety of Burfiralimab (hzVSF-v13) and DMRD (Disease-modifying Antirheumatic Drug)
The goal of this clinical trial is to evaluate the efficacy and safety of intravenous infusions of burfiralimab (hzVSF-v13) when added to Disease-Modifying Antirheumatic Drug (DMARD) treatment as Standard of Care (SOC) in…
- Trial name
- NCT06306339
- Testing
- Burfiralimab, SOC (Standard of care)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- ImmuneMed, Inc.
Juvenile Idiopathic Arthritis (JIA)
CAPRI National Juvenile Idiopathic Arthritis Registry
Juvenile Idiopathic Arthritis (JIA) is a disorder of unknown cause characterized by chronic inflammation of the joints and other organs.
- Trial name
- NCT03245801
- Where
- 15 sites in Canada
- Volunteers
- 1,238 people
- Sponsor
- University of British Columbia
Rheumatoid Arthritis
Synovial Tissue and Blood Signature of Rheumatoid Arthritis Patients With Disease Flare After Treatment Discontinuation for Sustained Remission.
Flares of immune-mediated inflammatory diseases, as Rheumatoid Arthritis (RA), are a major burden for patients in routine care. They occur unpredictably, adding to the physical and psychological burden of the condition.
- Trial name
- NCT05767801
- Testing
- Evaluation of subclinical inflammation
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rheumatoid Arthritis (RA)
Diet and Rheumatoid Arthritis Risk in the United Kingdom Women's Cohort
Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that…
- Trial name
- NCT06670144
- Testing
- Dietary pattern, Alcohol intake, Fruit and vegetables intake
- Where
- United Kingdom
- Volunteers
- 35,372 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Rheumatoid Arthritis (RA)
Assessment of Safety, Pharmacokinetics and Efficacy in a Combination Treatment With SMP-114
To compare the efficacy of SMP-114 (120 and 240 mg/d) versus placebo in terms of the percentage of patients meeting the American College of Rheumatology criteria for 20% improvement in RA (ACR20) at week 24.
- Trial name
- NCT00296257
- Testing
- SMP-114
- Where
- 46 sites in Czechia, Germany and 4 more
- Volunteers
- 312 people
- Sponsor
- Dainippon Sumitomo Pharma Europe LTd.
Rheumatoid Arthritis
Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis
An observational study to describe the effectiveness, safety, and patient-reported outcomes in patients with moderate to severe active rheumatoid arthritis (RA) receiving filgotinib in real-world setting.
- Trial name
- FILOSOPHY (NCT04871919)
- Testing
- Filgotinib
- Where
- 89 sites in Belgium, Germany and 4 more
- Volunteers
- 1,304 people
- Sponsor
- Alfasigma S.p.A.
Osteoarthritis, Rheumatoid Arthritis
Assessment of NSAID-treated Patients Adherence to Co-prescribed Proton Pump Inhibitor (PPI)
The primary objective of this cross-sectional observational real life study is to investigate the patient reported adherence to PPI, when prescribed as prevention of NSAID associated GI Ulcers to patients prescribed a NSAID.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- CONVOY (NCT01519375)
- Where
- 8 sites in Sweden
- Volunteers
- 102 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
First in Human Study of a Monoclonal Antibody (SOL-116) Targeting BSSL (Bile Salt-Stimulated Lipase), Single and Multiple Dose Parts
This is a randomized, double-blind, placebo-controlled, first-in-human phase I study. It consists of a single ascending dose part in healthy subjects (Part 1) and in patients with rheumatoid arthritis (Part 2) as well as a…
- Trial name
- NCT05576012
- Testing
- SOL-116
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Lipum AB