Clinical trials: Autoimmune Disorder
Relapsing Remitting Multiple Sclerosis (RRMS)
Disease Control and Safety in Patients With Relapsing Remitting Multiple Sclerosis (RRMS) Switching From Natalizumab to Fingolimod
This study evaluated disease control during different lengths of treatment transition from natalizumab to fingolimod.
- Trial name
- TOFIINGO (NCT01499667)
- Testing
- Fingolimod
- Where
- 44 sites in Australia, Austria and 9 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Immune Thrombocytopenia
Phase II Trial of Romiplostim With Danazol in Patients With Eltrombopag-resistant Immune Thrombocytopenia
In this study, we tried to demonstrate clinical benefit of additive danazol to romiplostim therapy in patients with eltrombopag-resistant immune thrombocytopenia
- Trial name
- NCT04289207
- Testing
- Romiplostim and danazol
- Volunteers
- 55 people
- Sponsor
- Seoul National University Hospital
Type I Diabetes
A Phase I/II Study of the Safety and Efficacy of Sernova's Cell PouchTM for Therapeutic Islet Transplantation
This is an open-label, single arm, non-randomized safety and efficacy study, where participants with Type-1 diabetes will receive the Sernova Cell Pouch™ implanted in the subcutaneous site, two to approximately twelve weeks prior…
- Trial name
- NCT01652911
- Testing
- Sernova Cell Pouch
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Juvenile Idiopathic Arthritis
The Efficacy of Influenza Vaccine Program in Children With Juvenile Idiopathic Arthritis. A Single Centre Results From Hungary
The aim of our study is to compare the immune function of patient treated with DMARD (methotrexate), or tumor necrosis factor (TNF)-alpha inhibitor (adalimumab) to healthy children. The study consists of three parts.
- Trial name
- NCT03833271
- Testing
- Influenza vaccine, Immune function
- Where
- Hungary
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Autoimmune Diseases, Immune System Diseases
Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple Sclerosis
The main purpose of this study is to evaluate the safety and feasibility of regenerative therapy with mesenchymal stem cells from adipose tissue, administered intravenously in patients with secondary progressive multiple…
- Conditions
- Autoimmune Diseases, Immune System Diseases, Demyelinating Diseases, Nervous System Diseases
- Trial name
- NCT01056471
- Testing
- Autologous mesenchymal stem cells from adipose tissue.
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Fear, Pain
Turkish Reliability and Validity of FOPQC-SF
The aim of this study is to question the Turkish validity and reliability of the "The Fear of Pain Questionnaire for Children Short Form (FOPQC-SF)" scale.
- Conditions
- Fear, Pain, Juvenile Idiopathic Arthritis
- Trial name
- NCT05439434
- Testing
- Fear of Pain Questionnaire for Children Short Form
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Pamukkale University
Autoimmune Diseases, Checkpoint Inhibitor
Checkpoint Inhibitors in Patients With Cancer and Underlying Autoimmune Disease
Patients with cancer and concurrent autoimmune diseases (AID) have been universally excluded from clinical trials evaluating immunotherapy.
- Conditions
- Autoimmune Diseases, Checkpoint Inhibitor, Immunotherapy
- Trial name
- CIAD (NCT04805099)
- Testing
- Checkpoint inhibitor
- Where
- Greece
- Volunteers
- 126 people
- Sponsor
- Hellenic Cooperative Oncology Group
Covid-19 Infection, Rheumatoid Arthritis
IMPACT: IMPact of Antimalarials on Covid-19 Infections in RAPPORT
This study aims to evaluate the experience of Alberta patients with inflammatory arthritis who participate in the the RAPPORT-ONTRAAC registry during the COVID-19 pandemic, specifically comparing the experience of those taking…
- Conditions
- Covid-19 Infection, Rheumatoid Arthritis, Psoriatic Arthritis, Hydroxychloroquine
- Trial name
- IMPACT (NCT04347798)
- Testing
- Hydroxychloroquine/Chloroquine
- Where
- Canada
- Volunteers
- 773 people
- Sponsor
- University of Alberta
Multiple Sclerosis
Safety of Polyphenon E in Multiple Sclerosis Pilot Study
This study is an open label 6 month study. All subjects will be treated with Polyphenon E (400 mg EGCG twice a day) for six months. The main outcome of this pilot phase will be safety.
- Trial name
- NCT00836719
- Testing
- Polyphenon E
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Neuromyelitis Optica Spectrum Disorder
Comparison of the Efficacy and Safety of Immunoadsorption and Plasma Exchange for Acute Attack of Refractory Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica spectrum disorder (NMOSD) is one common demyelinating disease of the central nervous system in young adults, with high rate of disability and recurrence, and poor natural course, which can cause a serious…
- Trial name
- CAMPUS (NCT04064944)
- Testing
- blood purification equipment
- Volunteers
- 144 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes, Type 2 Diabetes
A Prospective, Randomized, Parallel Crossover Study Demonstrating Subject Wearability and Usability of the I-Port Injection Port
This study investigated wearability and usability of the I-PORT™ Injection Port (I-PORT™), a new disposable injection port through which prescribed medication is injected subcutaneously from a standard syringe or pen.
- Trial name
- NCT00486109
- Testing
- I-Port(TM) Injection Port
- Where
- 5 sites in United States
- Volunteers
- 74 people
- Sponsor
- Patton Medical Devices
Multiple Sclerosis
Meningeal Inflammation on 7T MRI as a Tool for Measuring and Predicting Ocrelizumab Response in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disorder of the central nervous system. In MS, inflammation is known to attack areas of the brain, spinal cord, and optic nerves; resulting in disability.
- Trial name
- NCT03396822
- Testing
- Gadoteridol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Maryland, Baltimore
Multiple Sclerosis
Supervised Perturbation Training Results in Changes in Balance and Falling in Patients With Multiple Sclerosis
Physical exercise can prevent falls, certain types of exercise may be more effective. Perturbation-based balance training is a novel intervention involving repeated postural perturbations aiming to improve control of rapid…
- Trial name
- NCT04132167
- Testing
- perturbation training
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Suleyman Demirel University
Multiple Sclerosis, Relapsing-Remitting
Natalizumab Re-Initiation of Dosing
The primary objectives of this study are to further evaluate the safety of natalizumab (Tysabri®) monotherapy by evaluating the risk of hypersensitivity and immunogenicity following re-exposure to natalizumab, and to confirm the…
- Trial name
- NCT00306592
- Testing
- BG00002 (natalizumab)
- Where
- 63 sites in United States, Canada
- Volunteers
- 404 people
- Sponsor
- Biogen
Birth Defects, Pregnancy Complications
Betaseron Pregnancy Registry
This is a prospective, observational, registration and follow-up study of women exposed to Betaseron® at the time of conception (i.e., any time from the first day of the last menstrual period) and/or during pregnancy.
- Conditions
- Birth Defects, Pregnancy Complications, Multiple Sclerosis
- Trial name
- NCT00317564
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Syneos Health
Diabetes Mellitus, Type 1
Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes
Despite strong evidence that tight control of blood sugar reduces the risk of diabetes complications, most people with type 1 diabetes do not achieve recommended blood sugar targets.
- Trial name
- NCT06503809
- Testing
- Ketogenic Diet, Standard Diet
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Washington University School of Medicine
Hemophagocytic Lymphohistiocytosis (HLH), Macrophage Activation Syndrome (MAS)
Long Term Safety Study in Patients With HLH/MAS in Still's Disease Exposed to Gamifant.
This study aims to evaluate safety information in patients with HLH/MAS in Still's disease exposed to Gamifant.
- Conditions
- Hemophagocytic Lymphohistiocytosis (HLH), Macrophage Activation Syndrome (MAS), Still Disease
- Trial name
- NCT07909005
- Testing
- Local laboratory testing, Local Lab Tests
- Where
- 18 sites in United States
- Volunteers
- 70 people
- Sponsor
- Swedish Orphan Biovitrum
Rheumatoid Arthritis
Study With Etanercept Focusing on Remission and Predictability of Remission in Real Life Clinical Practice
Defining Which Remission Criterion at Month 6 Predicts Remission at Month 12 in a Real Life Clinical Practice, in a Cohort of Rheumatoid Arthritis Patients Treated with Etanercept
- Trial name
- REACH RA (NCT02202837)
- Testing
- etanercept
- Where
- 35 sites in Belgium
- Volunteers
- 157 people
- Sponsor
- Pfizer
Diabetes, Diabetes Mellitus, Type 1
The HEADWIND Study - Part 2
To analyse driving behavior of individuals with type 1 diabetes in eu- and progressive hypoglycaemia while driving in a real car.
- Trial name
- HEADWIND (NCT04569630)
- Testing
- Controlled hypoglycaemic state while driving
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis, Relapsing-Remitting
Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis.
HLA-DRB1 * Gene and some genes involved in inflammation and immunity (IL-7R, GPC5, CTSS) have been linked to risk of MS and the response to treatment with immunomodulators.
- Trial name
- WESTEMDRB1 (NCT02769767)
- Testing
- Polymorphism of Interleukins, Glypican, and Human Leukocyte Antigen Genes.
- Where
- Mexico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Instituto Jalisciense de Cancerologia
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