Clinical trials: Autoimmune Disorders
Fatigue
Ginseng in Treatment of Fatigue in Multiple Sclerosis
The purpose of this study was to evaluate the efficacy and safety of Ginseng in treatment of fatigue and Quality of Life of MS patients.
- Trial name
- NCT01712373
- Testing
- Ginseng
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Healthy Volunteers, Rheumatoid Arthritis
Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects
The purpose of this study is to investigate the drug interaction between fostamatinib and digoxin by comparing the safety, tolerability and plasma concentration of digoxin when administered alone and with fostamatinib in healthy…
- Trial name
- NCT01355354
- Testing
- Digoxin, Fostamatinib
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Multiple Sclerosis
Testing Mitochondria Activity and Blood Lipid Content of Multiple Sclerosis Patients
Background: Multiple sclerosis (MS) is a complex and multifactorial neurological disease characterized by infiltration of immune cells and progressive damage to myelin and axons.
- Trial name
- NCT01918501
- Testing
- Blood testing
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Vasculitis, Systemic Lupus Erythematosus (SLE)
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CCX168 in Healthy Participants
The primary objective of this study will be to evaluate the safety and tolerability of single and multiple oral doses of CCX168, over a range of dose levels, in healthy male and female participants.
- Trial name
- NCT05984251
- Testing
- CCX168
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Amgen
Multiple Sclerosis
Repetitive Deep Transcranial Magnetic Stimulation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic-inflammatory autoimmune central nervous system disorder and a leading cause of neurological disability in younger adults in Western countries.
- Trial name
- rTMS in MS (NCT01106365)
- Testing
- H-coil (Repetitive deep transcranial magnetic stimulation)
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Prescription Drug Safety and Effectiveness in Multiple Sclerosis
The goal of our research is to find out how safe and effective the drugs used to treat multiple sclerosis (MS) are when used in the everyday, real world. To achieve these study goals, we have two main study Themes.
- Trial name
- DRUMS (NCT04472975)
- Testing
- Exposure to one or more disease-modifying drug(s)(DMDs) used to treat MS
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Rheumatoid Arthritis
Evaluation of the Condition of Rheumatoid Arthritis After Treatment
To examine the safety and effectiveness after Xeljanz treatment in rheumatoid arthritis patients
- Trial name
- NCT02157012
- Testing
- The effectiveness of Xeljanz in rheumatoid arthritis patients
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shinshu University
Systemic Lupus Erythematosus, Quality of Life
Peer Approaches to Lupus Self-management
The Peer Approaches to Lupus Self-Management (PALS) study is a randomized, controlled in which 360 African American women with lupus will be recruited from the MUSC SLE database (60 mentors and 300 mentees).
- Conditions
- Systemic Lupus Erythematosus, Quality of Life, Behavior, Health
- Trial name
- PALS (NCT03734055)
- Testing
- Peer Mentoring, Social Support Group
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Systemic Lupus Erythematosus
Regulatory BCells in Systemic Lupus Erythematosus
Systemic lupus erythematosus , the archetypal multisystem autoimmune disease, presents many diagnostic and management challenges.
- Trial name
- NCT03178721
- Testing
- blood sample
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Diabetes Mellitus, Type 1
TrialNet Pathway to Prevention of T1D
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00097292
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Rheumatoid Arthritis
Ticagrelor in Methotrexate-Resistant Rheumatoid Arthritis
This is an open label study to assess the improvement in the Disease Activity Score for 28-joint counts (DAS28) with ticagrelor given at 90 mg twice daily in patients with RA who have active disease despite MTX therapy (as…
- Trial name
- TIMERA (NCT02874092)
- Testing
- Ticagrelor, MTX therapy
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Arthritis, Rheumatoid, Syndrome, Metabolic
An Exploratory Clinical Study on Autophagy During Fasting
Autophagy is considered one of the key molecular mechanisms for the broad preventive and therapeutic effects of periodic fasting.
- Conditions
- Arthritis, Rheumatoid, Syndrome, Metabolic, Healthy
- Trial name
- NCT04739852
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 1
Assess the Impact of Insulclock on Glycemic Variability and Treatment Compliance in Uncontrolled DM1 Patients
Insulclock® is a small electronic device developed to facilitate the optimal administration of insulin. This device works as an add-on module of commercially available insulin pens and monitors the date, time and dose of…
- Trial name
- Segoclock2 (NCT04847778)
- Testing
- Use of Insulclock system, both Insulclock device and Insulclock 360 app., Use of Insulclock system, both Insulclock device and Insulclock app on masked mode.
- Where
- 4 sites in Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital General de Segovia
Type 1 Diabetes (T1D), Type 2 Diabetes
Capillary OGTT Study
Type 1 diabetes (T1D) is a chronic condition, affecting 1 in 490 children under the age of 15 years. It is caused by the immune system damaging the pancreas, the organ which makes insulin.
- Trial name
- CapOGTT (NCT06815081)
- Where
- 4 sites in United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Exercise, Healthy Participants
Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial
The goal of this clinical trial is to investigate if blood glucose responses are similar between and within individuals in response to standardized exercise in adults with and without Type 1 diabetes.
- Conditions
- Exercise, Healthy Participants, Glucose Variability, Type 1 Diabetes (T1D)
- Trial name
- NCT07209930
- Testing
- Exercise, Rest
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Type 1 Diabetes
Assessment of Beta Cell Mass by PET Scans With [11C] Dihydrotetrabenazine (DTBZ) in Longstanding Type 1 Diabetes.
We hypothesize that quantitative measurements of the beta cell mass within the endocrine pancreas can be obtained by PET via targeting of vesicular monoamine type 2 transporters with the radioligand [11C]DTBZ.
- Trial name
- NCT00738907
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Multiple Sclerosis
Disability Level and Trunk Control in Individuals With Multiple Sclerosis
Trunk control disorders are frequently encountered in individuals with MS. Trunk control is very important for safe and quality movement.
- Trial name
- NCT05634993
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Type1 Diabetes
The Role of the Thymus in Type I Diabetes.
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases.
- Trial name
- TregDiab (NCT03236558)
- Testing
- Blood collection
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Diabetes Mellitus, Type 1, NASH
Effect of Dipeptidyl Peptidase- 4 Inhibitors on Non-Alcoholic Steatohepatitis and Type 1 Diabetes
Background: Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) that can precipitate to advanced fibrosis and leads to cardiovascular morbidity and mortality.
- Trial name
- NCT06348706
- Testing
- Dipeptidyl peptidase 4 (DPP-4) inhibitor
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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