Clinical trials: Autoimmune Disorders
Diabetes, Celiac Disease
Gfree - For Improved Blood Sugar and Reduced Inflammation.
The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes.
- Conditions
- Diabetes, Celiac Disease, Autoimmunity, Metabolic Disease
- Trial name
- NCT05894746
- Testing
- gluten-free, probiotic, gluten
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Systemic Lupus Erythematosus, Gastrointestinal Diseases
Subclinical Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus
This cross-sectional case-control study aims to evaluate fecal calprotectin levels and intestinal ultrasound findings for the detection of subclinical gastrointestinal involvement in children with juvenile systemic lupus…
- Trial name
- NCT07858461
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arthritis, Rheumatoid
Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.
- Trial name
- NCT00748254
- Testing
- Laser Based Photoacoustic Tomography, MRI, Ultrasound
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Type 1 Diabetes
Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes
Diabetes Inspired Culinary Education (DICE) is an innovative family- and community-based culinary medicine intervention designed to mitigate racial/ethnic and socioeconomic status disparities in the treatment and health outcomes…
- Trial name
- DICE (NCT07084805)
- Testing
- Diabetes Inspired Culinary Education (DICE) - Phase 1, Diabetes Inspired Culinary Education (DICE) - Phase 2
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Juvenile Idiopathic Arthritis
Access to Pediatric Rheumatology Centers for JIA Patients: Factors Associated With Time to Access Pediatric Rheumatology Centers
JIA patients, their parents, and the health care professionals experience the complexity of the initial care pathway. The aim of the study is to explore the referral pathway to access pediatric rheumatology centers for JIA…
- Trial name
- AJILITT (NCT05696340)
- Testing
- semi-structured interview
- Where
- 4 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
The Relationship Between Fatigue and Physical Activity Level in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, progressive and unpredictable disease of the central nervous system. In MS, various loss of strength, balance and gait disturbances arise in the central nervous system due to sensory and/or…
- Trial name
- NCT03255460
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis, Breath Tests
The Relationship Between Mechanical Properties of Respiratory and Lower Extremity Muscles and Other Parameters in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease characterised by deterioration in the mechanics of the lower extremities and respiratory muscles and a decrease in respiratory function.
- Conditions
- Multiple Sclerosis, Breath Tests, MyotonPRO
- Trial name
- NCT07202780
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sanko University
Type 1 Diabetes
Imaging of Type 1 Diabetes Progression
Type 1 diabetes results from the autoimmune destruction of the insulin-producing beta cells of the islets of Langerhans of the pancreas.
- Trial name
- NCT01521520
- Testing
- ferumoxytol
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jason Gaglia
Chemotherapy-induced Thrombocytopenia, Immune Thrombocytopenic Purpura
A Study of PN20 in Healthy Adult Volunteers
The main aim of this clinical trial is to assess the safety of PN20 in healthy volunteers aged 18 to 50 years. The main questions it aims to answer are: Is PN20 safe in adult? Researchers will compare PN20 to a placebo (a…
- Trial name
- NCT06523088
- Testing
- PN20
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Chongqing Peg-Bio Biopharm Co., Ltd.
Type 1 Diabetes (T1D)
"Perception, Knowledge, and Attitudes of Educational Staff Regarding the Care of Children With Type 1 Diabetes: Evaluation of the Educational Program"
Type 1 diabetes is a chronic autoimmune disease that requires continuous monitoring and regulation of glycemia. Children with type 1 diabetes face challenges that can disrupt their daily routines in school and kindergarten.
- Trial name
- PKA-T1D-EDU (NCT07148076)
- Testing
- Education Program
- Where
- 2 sites in Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sibenik University of Applied Sciences
Prediabetes, Diabetes Type 1
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms
G (guanine nucleotide binding) proteins associating with G protein-coupled receptors (GPCR) are key players in the pathogenesis of obesity and diabetes and are targets of pharmacotherapeutic inter-ventions.
- Conditions
- Prediabetes, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT02057497
- Volunteers
- healthy volunteers welcome
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Sclerosis, Multiple
Application of ihMT MRI in Multiple Sclerosis
The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating therapies in multiple sclerosis.
- Trial name
- ihMTMS (NCT03600779)
- Testing
- inhomogeneous Magnetisation Transfer (ihMT) sequence, inhomogeneous Magnetisation Transfer (ihMT) sequence at 3T
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetes Mellitus, Type 1
Early Dietary Intervention and Later Signs of Beta-Cell Autoimmunity
The proposed mechanistic formula feeding study sets out to identify the mechanism(s) by which an extensively hydrolyzed casein formula is able to protect children at risk for type 1 diabetes (T1D) from beta-cell autoimmunity.
- Trial name
- EDIA (NCT01735123)
- Testing
- dietary intervention
- Where
- Finland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Graves Disease
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
Patients with GD often present with glucose dysregulation, which, according to most studies, is associated with islet β-cell dysfunctions, enhanced gluconeogenesis and insulin resistance (IR).
- Trial name
- NCT02376088
- Testing
- Methimazole
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Weikai Hou
Diabetes Type 1, Diabetes Mellitus, Type 2
Antenatal Hand Milking for Pregnant Women With Diabetes'
The project is a descriptive cohort study with a retrospective and a prospective group where pregnancy and childbirth data will be studied.
- Conditions
- Diabetes Type 1, Diabetes Mellitus, Type 2, GDM
- Trial name
- NCT04794283
- Testing
- Breast milk
- Where
- Sweden
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Type 1 Diabetes Mellitus
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)
Type 1 Diabetes Mellitus (T1DM) is a well-studied autoimmune disease resulting in insulin deficiency due to selective β-cell destruction.
- Trial name
- METHYLDIAB (NCT04139369)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes, Hypoglycemia
Impact of Hypoglycemia Unawareness on Brain Metabolism Cognition in T1DM
The research study is designed to examine the impact of low blood sugar on brain function in individuals with Type 1 Diabetes who have frequent and severe hypoglycemia (low blood sugar) compared to those who do not.
- Trial name
- NCT00575783
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Yale University
Genetic Predisposition to Disease
RORC Genetic Polymorphism of Rheumatoid Arthritis
Three candidate single nucleotide polymorphisms in the RORC2 gene, rs9826 A/G, rs3790515 C/T and rs3828057 C/T were examined together with estimation of nuclear hormone retinoic acid receptor-related orphan receptor variant 2…
- Trial name
- NCT03615729
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
GSK239512 DDI Study
The study will determine the effect of 400 mg once daily of ketoconazole at steady state on the pharmacokinetics of a single oral dose of GSK239512 in young healthy volunteers.
- Trial name
- NCT01802931
- Testing
- GSK239512, ketoconazole
- Where
- Australia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes Mellitus
Fr1da Early Diagnosis and Care of Type 1 Diabetes
The Fr1da study: "Early diagnosis and care of type 1 diabetes" aims to carry out a comprehensive, population-based screening for the early diagnosis of type 1 diabetes as part of the U7 to U11 preventive medical check-up for…
- Trial name
- Fr1da (NCT04039945)
- Where
- Germany
- Volunteers
- 285,000 people, healthy volunteers welcome
- Sponsor
- Helmholtz Zentrum München
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