Clinical trials: Autoimmune Disorders
Systemic Lupus Erythematosus, Physiopathology
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
This study evaluates the variation of expression of the neonatal Fc receptor (FcRn) in Natural Killer T Cells Expressing an Invariant T Receptor (iNKT) and monocytes along with the surface expression of Fc gamma type II receptor…
- Trial name
- FiNKLUPUS (NCT05859191)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Type 1 Diabetes Mellitus
Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas
BACKGROUND. Optimal glucose control can prevent/relent tissue damage in patients with type 1 diabetes mellitus (T1DM). Ongoing efforts aim at developing closed loop control (CLC) algorithms linking subcutaneous continuous glucose…
- Trial name
- NCT02003274
- Testing
- Clamp-Mixed Meal, IVGTT-Mixed Meal Arm
- Where
- 2 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Idiopathic Membranous Nephropathy
Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy
The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive…
- Trial name
- NCT01799460
- Testing
- The Comprehensive Treatment Regimen of Traditional Chinese Medicine, The immunosuppressive agents
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Type 1 Diabetes
Insulin Exposure and Glucose Response to Meals in Type 1 Diabetic Subjects Administered Two Different Insulin Regimens Compared to the Endogenous Insulin Exposure and Glucose Response to Meals In Healthy Adult Controls
Intensive control of Type 1 Diabetes is critical in prevention of long term complications. Unfortunately, there is a three-fold increase in hypoglycemia with intensive control.
- Trial name
- NCT00927524
- Testing
- Insulin glulisine, Insulin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Multiple Sclerosis
Analysis of a Biomarker Signature in Patients With Multiple Sclerosis (MS) Treated With Gilenya (FTY720)
This study investigates whether there is a link between disease activity/progression in patients receiving Gilenya and expression of a putative biomarker signature in patients with multiple sclerosis.
- Trial name
- MS (NCT02408380)
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University
SARS-Cov-2 Infection, Rheumatoid Arthritis
Deciphering a Specific Signature of the Immunosenescence Induced in COVID-19+ Patients Versus Rheumatoid Arthritis Patients
Immune aging or immunosenescence is characterized by a loss of T cell clonal diversity and a contraction of naïve T cells with proliferative capacity associated with the functional impairment of many others immune cells as well…
- Trial name
- SENO-COVID (NCT04880720)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
Baseline Cortical Haemodynamics in MS
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease.
- Trial name
- CortHaem (NCT02481882)
- Testing
- Magnetic Resonance Imaging, Prohance (Gadoteridol)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
Multiple Sclerosis and Respiratory and Functional Capacity
It is known that respiratory functions, physical activities and functional capacities of Multiple Sclerosis (MS) patients decrease with the progression of the disease.
- Trial name
- NCT05697523
- Testing
- Expanded Disability Status Scale, pulmonary function test, International Physical Activity Questionnaire - Short Form, 6 minute walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Healthy, Type 1 Diabetes
The Effect of Lixisenatide on the Effect of Pituitary Hormones
The current study has two aims: 1. to test the hypothesis that a single dose of lixisenatide can be used as a growth hormone stimulation test; 2.
- Trial name
- NCT05804513
- Testing
- Lixisenatide 10 micrograms (50 micrograms/ml in 3 ml) Pen Injector
- Where
- Estonia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Rheumatoid Arthritis
Cross-over Study to Investigate Retinal Function Following Administration of a Single Dose of AZD9056
The purpose of the study is to determine whether treatment with a single 800mg dose of AZD9056, a medication which has been developed as a possible treatment for Rheumatoid Arthritis, has an effect on the function of the retina
- Trial name
- NCT00700986
- Testing
- AZD9056
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Takayasu's Arteritis, Giant Cell Arteritis
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Background: Vasculitis is a group of diseases that inflame and damage blood vessels and tissue. It can cause many medical problems. Few tests can diagnose the disease, and none can reliably predict a relapse.
- Conditions
- Takayasu's Arteritis, Giant Cell Arteritis, Polyarteritis Nodosa, Relapsing Polychondritis
- Trial name
- NCT02257866
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
IgA Nephropathy
Study of ARO-CFB in Adult Healthy Volunteers
The purpose of AROCFB-1001 is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ARO-CFB Injection in adult healthy volunteers (HVs). HVs will receive either one or two doses of ARO-CFB or placebo.
- Trial name
- NCT06209177
- Testing
- ARO-CFB
- Where
- New Zealand
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Multiple Sclerosis
Novel Nanosensor Array for Detection of Volatile Biomarkers From Skin in Multiple Sclerosis
Multiple Sclerosis (MS) is the most common chronic neurological disease affecting young adults, with onset usually at the age 20-40 years.
- Trial name
- Nano-Skin-MS (NCT04074629)
- Testing
- Diagnosis, skin volatile organic compounds (VOCs)
- Where
- Israel
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Rheumatoid Arthritis
Exercise on microRNA in Rheumatoid Arthritis
The goal of this prospective cohort study is to learn about whether exercise alters microRNA expression levels in 30 rheumatoid arthritis patients and 30 healthy controls.
- Trial name
- NCT05914337
- Testing
- exercise, gene expressions of miRNA
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Study of CIDP Patients During IVIG Treatment
The aim of this study is to quantify the effect of IVIG treatment in a group of patients with chronic inflammatory demyelinating polyradiculoneuropathy(CIDP), who requires continues treatment of IVIG at regular intervals of 3-10…
- Trial name
- NCT00305266
- Testing
- intravenous gammaglobulin
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Multiple Sclerosis, Periodontitis
Periodontal Health Profile in Multiple Sclerosis Patients
This study aims to evaluate the periodontal status of patients with Multiple Sclerosis (MS) through clinical, microbiological, and biochemical parameters.
- Trial name
- NCT07412431
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pemphigus, Bullous Pemphigoid
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
Pemphigus is a rare autoimmune life-threatening blistering condition affecting skin and mucous membranes. Pemphigus belongs to a family of polygenic disorders.
- Conditions
- Pemphigus, Bullous Pemphigoid, Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
- Trial name
- NCT05284929
- Testing
- A single blood sample for HLA typing
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sechenov University
Secondary Progressive Multiple Sclerosis
Measuring Active Microglia in Progressive Multiple Sclerosis
This is pilot study designed to quantifying the innate immune inflammatory burden in a cohort of secondary progressive multiple sclerosis subjects.
- Trial name
- NCT02207075
- Testing
- [C11]PK-1195 PET scan
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Depression, Systemic Lupus Erythematosus
Intervention to Improve Quality of Life in African American Lupus Patients
The goal of the proposed project is to enhance the Principal Investigator's research ability to conduct behavioral interventions for people with lupus.
- Trial name
- IQAN (NCT01837875)
- Testing
- Chronic Disease Self-Management Program (CDSMP), Mail-delivered arthritis kit, Support group
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Type 1 Diabetes
The Israeli Study for Islet Autoantibodies Screening in Families of Type-1 Diabetes Patients
We aim at establishing a research program that will offer screening for the presence of Islet Autoantibodies (IA) in relatives of people with Type 1 Diabetes (T1D).
- Trial name
- NCT05788341
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.