Clinical trials: Autoimmune Liver Diseases
Autoimmune Liver Diseases, Immunological Mechanisms
The MAI-FOIE Cohort
The MAI-FOIE cohort will be a French multicenter cohort with the development of a biobank including patients with autoimmune, metabolic and medicated liver diseases
- Trial name
- NCT07594990
- Where
- 13 sites in France
- Volunteers
- 800 people
- Sponsor
- Nantes University Hospital
Arthritis, Rheumatoid
Non Alcoholic Fatty Liver Disease in Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory systemic disease. It has a worldwide distribution and can affect all age group. The peak incidence is between fourth and sixth decade.
- Trial name
- NCT00394238
- Testing
- Ultrasonographic imaging
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes
Sphingolipids are associated with metabolic diseases. Distribution of plasma sphingolipids in type 1 and type 2 diabetes has never been studied.
- Trial name
- CERADIAB (NCT03447964)
- Testing
- dosing of sphingolipids
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Autoimmune Hepatitis, AIH
A Trial of Inebilizumab in Participants With Autoimmune Hepatitis
The main objectives of this trial are to evaluate the safety and tolerability of inebilizumab in participants with autoimmune hepatitis (AIH) (Part 1) and to evaluate the efficacy of inebilizumab on AIH disease activity and…
- Trial name
- MERCURY (NCT07598825)
- Testing
- Inebilizumab, Standard of Care
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Amgen
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Rheumatoid Arthritis, Non-Alcoholic Steatohepatitis
A Study to Assess the Safety and Tolerability of LB-P6 and LB-P8 in Healthy Participants
The study is designed to assess the safety and tolerability of multiple ascending doses of LB-P6 or LB-P8 in healthy participants.
- Trial name
- NCT05053165
- Testing
- LB-P6, LB-P8
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- LISCure Biosciences
Type1diabetes, Fatty Liver
Night Hyperglycemia and Fatty Liver in Type 1 Diabetes
This clinical trial aims to discover the relationship between hyperglycemia at night and early morning hours and the presence of fatty liver in patients with type 1 diabetes.
- Trial name
- NCT05933018
- Testing
- liver elastography
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Graves Disease
Effective Iodide Therapy for Untreated Patients With Graves' Hyperthyroidism Avoiding Thionamide Drugs With Many Side Effects
As the drug treatment of Graves' hyperthyroidism, Plummer reported the effectiveness of excess iodide in 1923 and iodide was used as the therapy for Graves' hyperthyroidism starting from the 1930s.
- Trial name
- NCT04686006
- Testing
- Potassium Iodide
- Volunteers
- 504 people
- Sponsor
- Kyushu University
Type 1 Diabetes, Bariatric Surgery Candidate
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging
The primary objective of this study is to assess hepatic glucose uptake using non-invasive metabolic imaging in three different populations that differ in terms of insulin and glucose kinetics.
- Trial name
- LEMON (NCT04352738)
- Testing
- Multiparametric, multinuclear MR (DMI/ 13C-MRS/ GlycoCEST/GlycoNOE)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Autoimmune Hepatitis
A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA)
This was a Phase 2a, multi-center, placebo-controlled study in which patients with autoimmune hepatitis received zetomipzomib or placebo in addition to standard-of-care for 24 weeks; an optional open-label extension period…
- Trial name
- NCT05569759
- Testing
- zetomipzomib, zetomipzomib in open-label extension
- Where
- 24 sites in United States
- Volunteers
- 24 people
- Sponsor
- Kezar Life Sciences, Inc.
Hepatitis B Virus Associated Nephrotic Syndrome
Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN)
This study was to evaluate the efficacy and safety of Tacrolimus combined with entecavir antiviral therapy for HBV-associated glomerulonephritis in china.
- Trial name
- TOHBVGN (NCT03062813)
- Testing
- Tacrolimus &entecavir
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Guangdong Provincial People's Hospital
Autoimmune Diseases
Gut Microbiota In Children With Autoimmune Liver Disease and Its Effect on Treatment Response
Gut microbiota and liver disease are very closely linked. Microbiota influences the various liver diseases by Dysbiosis ratio .There is loss of tolerance targeting liver antigens which is thought to initiate disease in…
- Trial name
- NCT06183190
- Testing
- No intervention
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C, Lichen Planus
Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection
This study will be conducted on 30 patients with mucocutaneous complaints and documented HCV infection. The study will be done at Tropical medicine department , Tanta university.
- Conditions
- Hepatitis C, Lichen Planus, Vasculitis, Autoimmune Diseases
- Trial name
- NCT02261662
- Testing
- Ribavirin, Betamethasone
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Autoimmune Hepatitis, Liver Disorder
Development of a Autoimmune Hepatitis Patient's Database Linked to a Biological Sample Storage
Autoimmune Hepatitis (AIH) is chronic fibroinflammatory disease of the liver characterized by chronic, relapsing liver inflammation, and a risk for progression to liver failure and need for liver transplantation.
- Trial name
- AIH Database (NCT06078098)
- Testing
- Clinical Information
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milano Bicocca
Hepatitis, Autoimmune, Autoimmune Hepatitis
Swiss Autoimmune Hepatitis Cohort Study
Research project in which biological material is sampled and health-related personal data is further used and collected. Coded data are used.
- Trial name
- NCT03146884
- Where
- 20 sites in Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fondazione Epatocentro Ticino
Hepatitis C, Hepatitis B
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis
The purpose of this research is to study body materials like blood proteins as well as white blood cell and liver cellular RNA in individuals with liver diseases such as chronic viral hepatitis with or without hepatoma and…
- Conditions
- Hepatitis C, Hepatitis B, Autoimmune Hepatitis, Liver Cirrhosis, Biliary
- Trial name
- NCT00160940
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Liver Disease
Mycophenolate Mofetil Immunosuppression Without/With Reduced Dose Calcineurin Inhibitor Long After Liver Transplantation
The purpose of the study is to assess the safety and efficacy of mycophenolate mofetil alone, or with reduced dose cyclosporine (CsA) or tacrolimus, for immunosuppression long-term after liver transplantation, in an attempt to…
- Trial name
- NCT00206076
- Testing
- mycophenolate mofetil
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Albert Einstein Healthcare Network
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Drug-induced Liver Injury, Autoimmune Hepatitis
Discrimination of DILI and AIH by Artificial Intelligence
A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis.
- Trial name
- NCT05532345
- Where
- China
- Volunteers
- 2,583 people
- Sponsor
- Beijing Friendship Hospital