Clinical trials: Autoimmune State, open to volunteers
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Type 1 Diabetes (T1D), Autoantibodies
Standardized Italian netwoRk Enrolling iNdividuals With Islet-Autoantibodies
This project characterizes the longitudinal progression of children and adults who have tested positive for one or more islet cell autoantibodies across the early stages of type 1 diabetes (T1D).
- Conditions
- Type 1 Diabetes (T1D), Autoantibodies, Hyperglycemia, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- SIRENA (NCT07503366)
- Where
- 24 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Società Italiana di Endocrinologia e Diabetologia Pediatrica
Autoimmune Thyroid Disease
Risk Assessment of Pancreatic Islet Autoimmunity in Patients With AITD
This study aims to evaluate the risk of islet autoimmunity in patients with autoimmune thyroid disease (AITD), describe related clinical and laboratory characteristics, and explore the development of a risk assessment model based…
- Trial name
- NCT07494474
- Testing
- Islet autoantibodies tested
- Volunteers
- 834 people
- Sponsor
- Nanjing Medical University
Type 1 Diabetes, Autoimmune Diabetes
Intensive Dietary and Activity Counselling (IDAC)
The aim of this intervention study is to investigate if a intensive dietary and physical activity counselling during the first two years of life in children with increased (genetically) risk for Type 1 Diabetes (T1D) can promote…
- Trial name
- IDAC (NCT06670625)
- Testing
- IDAC+
- Where
- Sweden
- Volunteers
- 1,244 people
- Sponsor
- Lund University
Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems.
- Conditions
- Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency, Immune System Diseases, Autoimmune Lymphoproliferative
- Trial name
- NCT02579967
- Testing
- Immunosuppression Only Conditioning -Closed with amendment L, Reduced Intensity Conditioning, Myeloablative Conditioning-Closed with amendment L
- Where
- 2 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Graves Disease, Amiodarone-Induced Thyrotoxicosis
Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis
The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status.
- Conditions
- Graves Disease, Amiodarone-Induced Thyrotoxicosis, Thyroidectomy
- Trial name
- GRATES (NCT06963203)
- Where
- 15 sites in Belgium, France and 3 more
- Volunteers
- 486 people
- Sponsor
- Andrea Goldmann
Diabetes, Diabetes Mellitus, Type 1 Diabetes
Argus 2.0 Adoption Study
This study evaluates the usability of the KOS Argus Continuous Glucose Monitoring (CGM) System, a noninvasive, wrist-worn device that estimates blood glucose levels using light-based sensors and artificial intelligence…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 2, Prediabetes
- Trial name
- NCT07425236
- Testing
- KOS Argus Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- KOS Inc.
Diabetes, Celiac Disease
Gfree - For Improved Blood Sugar and Reduced Inflammation.
The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes.
- Conditions
- Diabetes, Celiac Disease, Autoimmunity, Metabolic Disease
- Trial name
- NCT05894746
- Testing
- gluten-free, probiotic, gluten
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Type 1 Diabetes, Diet Intervention
Effect of Different Carbohydrate Intake Patterns on Glycemic Control in Patients With Type 1 Diabetes
This multicenter, randomized, controlled, open-label clinical trial aims to evaluate the effects of different carbohydrate intake patterns on glycemic control in adults with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Diet Intervention, Glucose Control
- Trial name
- NCT06273631
- Testing
- diverse carbohydrate diet, moderate carbohydrate diet
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Yang Tao
Arrhythmogenic Cardiomyopathy
Diagnostic Contribution, Prognosis and Physiopathological Aspects in Arrhythmogenic Cardiomyopathy. (ACORE)
This study aims to identify novel inflammatory biomarkers in AC, whether in circulating blood, in situ or as imaging biomarkers to better understand the pathophysiology of the disease and then to determine contribution to the…
- Trial name
- ACORE (NCT05569356)
- Testing
- Prospective, Retrospective
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus
SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by progressive destruction of pancreatic beta cells mediated by autoreactive T lymphocytes, resulting in absolute insulin deficiency.
- Trial name
- SHIELD-T1D (NCT07614412)
- Testing
- Recombinant Zoster Vaccine (Shingrix; RZV), Semaglutide (Ozempic®)
- Where
- Saudi Arabia
- Volunteers
- 240 people
- Sponsor
- Ministry of Health, Saudi Arabia
Lupus Erythematosus, Systemic
The Effect of Clinical Pilates Training on Fatigue, Emotional State, Functional Capacity, Sleep and Quality of Life in Women With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease with the potential to affect any organ in the body.
- Trial name
- NCT07394361
- Testing
- Clinical Pilates Training, Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Emir İbrahim IŞIK
Type 1 Diabetes
A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States
This study is an observational, longitudinal, non-interventional real-world study in the United States. The study is meant to describe the experience of participants with a history of stage 2 type 1 diabetes who have been infused…
- Trial name
- TEPLI-QUEST (NCT07260110)
- Testing
- Teplizumab
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Sanofi
Schizo-Affective Type of Psychosis, Schizophrenia
Ocrelizumab for Psychosis by Autoimmunity
Some people who have what doctors currently call schizophrenia or bipolar disease may actually have a brain disease caused by auto-antibodies.
- Trial name
- OPA (NCT03971487)
- Testing
- Psychosis and cognitive assessments, Physical and neuro-cognitive evaluations, Safety labs and electrocardiogram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Dermatomyositis, Polymyositis
Adult and Juvenile Myositis
This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their cause and the immune system changes and medical problems associated with them.
- Conditions
- Dermatomyositis, Polymyositis, Inclusion Body Myositis
- Trial name
- NCT00017914
- Where
- 4 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Status Epilepticus, Dysimmune Encephalopathy
Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to…
- Trial name
- COLETTE (NCT04421846)
- Testing
- Blood sampling, cerebrospinal fluid , post-mortem cerebral tissues (NA for the Group 3), Blood sampling, cerebrospinal fluid, stool sampling post-mortem cerebral tissues (NA for the Group 3)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroiditis, Autoimmune, Infertility
Effect of Prednisone and Aspirin on IVF-ET Outcome Among Patients With Thyroid Autoimmunity
This trial was a 1:1 (active:placebo) randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of prednisone and aspirin for the in vitro fertilization and embryo transfer outcome among patients with…
- Trial name
- NCT05578456
- Testing
- Prednisone and Aspirin
- Volunteers
- 540 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Keratitis, Autoimmunity
A Clinical Study to Evaluate the Safety and Effectiveness of MSCohi-O Lens in the Treatment of Immune-related Ocular Surface Diseases.
Immune-related ocular surface diseases are a kind of non-infectious eye disease pedigree, which is mediated by abnormal immune system function and characterized by ocular surface tissue damage.
- Conditions
- Keratitis, Autoimmunity, Dry Eye Disease (DED)
- Trial name
- NCT07902687
- Testing
- MSCohi-O lens
- Volunteers
- 20 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Rheumatoid Arthritis (RA), Crohn's Disease (CD)
Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis
This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of…
- Conditions
- Rheumatoid Arthritis (RA), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07524244
- Testing
- Ketogenic diet, Carnivore (Lion) Diet
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Fuller Research Foundation