Clinical trials: Autoimmunity, Inflammation
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Arthritis, Rheumatoid, Inflammatory Response
Postprandial Inflammation in Rheumatoid Arthritis
Patients with RA will be studied to see whether meals of different content will affect inflammation and metabolic variables in the postprandial state.
- Conditions
- Arthritis, Rheumatoid, Inflammatory Response, Dietary Exposure, Diet, Healthy
- Trial name
- PIRA (NCT04247009)
- Testing
- Meal based on red meat, fish products or vegan products, Meal based on red meat
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Central Nervous System Disease, Multiple Sclerosis
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system.
- Trial name
- NCT00794352
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Long Covid19, Post COVID-19 Condition
All Eyes on PCS - Analysis of the Retinal Microvasculature in Patients With Post-COVID-19 Syndrome
The goal of this observational, prospective study is to in depth analyze the retinal microvasculature in patients with Post-COVID-19 Syndrome (PCS).
- Conditions
- Long Covid19, Post COVID-19 Condition, Endothelial Dysfunction
- Trial name
- NCT05635552
- Testing
- Dynamic retinal vessel analysis (DVA), Optical coherence tomography (OCT), Biochemistry and immune phenotyping
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Rheumatoid Arthritis
Effect of Exercise on the Disease Activity of Rheumatoid Arthritis
This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.
- Trial name
- RA&Ex (NCT00792675)
- Testing
- Aerobic and resistance exercise training
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD).
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, MOG Antibody-Associated Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NeuroDIP (NCT07902479)
- Testing
- Blood sampling and multi-omic profiling
- Where
- 5 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Lupus Nephritis, Systemic Lupus Erythematosus (SLE)
Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months of Intensified Treatment With Prednisolone, Mycofenolate Mofetil and Voclosporin as Compared to Mycofenolate Mofetil and Prednisolone
The goal of this clinical trial is to learn how different treatments affect immune cells in the kidney in people with active lupus nephritis (LN), a kidney manifestation of systemic lupus erythematosus (SLE).
- Trial name
- MAPLE (NCT07760480)
- Testing
- Kidney Biopsy, Voclosporin (LUPKYNIS), Blood, feces and urine sample collection
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Alzheimer Disease, Parkinson Disease
Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
The underlying goal of this study is to assess [18F] PBR06 PET imaging as a tool to detect microglial activation in the brain of Alzheimer Disease (AD), Parkinson Disease (PD) and Multiple Sclerosis (MS) research participants.
- Conditions
- Alzheimer Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- PBR06 (NCT01028209)
- Testing
- [18F] PBR06
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Inflammation, Systemic Lupus Erythematosus
Dose-escalation Trial of Anti-C5aR Antibody in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to develop a complement system targeted monoclonal antibody (mAb) to be used in treatment of subjects with chronic autoimmune diseases.
- Conditions
- Inflammation, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Healthy
- Trial name
- NCT02151409
- Testing
- NNC 0151-0000-0000
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Participants, Healthy Subjects
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses and Food Effect of BGB-45035 in Healthy Participants and in Adults With Autoimmune Dermatological Diseases
This study is the first-in-human (FIH) study of BGB-45035. The study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BGB-45035 with both a single dose and multiple doses administered at different…
- Conditions
- Healthy Participants, Healthy Subjects, Healthy Volunteers, Autoimmune Diseases
- Trial name
- NCT06342713
- Testing
- BGB-45035
- Where
- 13 sites in Australia, China and 1 more
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- BeiGene
Type 1 Diabetes
Role of Intestinal Inflammation in the Pathogenesis of Type 1 Diabetes
This purpose of this study is to determine if activation of a person's immune system in the small intestine could be a contributing cause of Type 1 Diabetes.
- Trial name
- NCT01940835
- Testing
- Upper endoscopy with small bowel biopsies and brushings., Blood draw, Stool sample
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Multiple Sclerosis
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, [18F]-FZTA, to detect inflammation in the brain.
- Trial name
- FZTA Pilot (NCT07115017)
- Testing
- [18F] FZTA
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Rheumatoid Arthritis, Endothelial Dysfunction
Atherosclerosis in Rheumatoid Arthritis
The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial function.
- Trial name
- NCT00990730
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Inflammation, Rheumatoid Arthritis
Safety and Tolerability of Anti-IL-20 in Healthy Volunteers and Patients With Rheumatoid Arthritis
This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety and tolerability of single doses of Anti-IL-20 in healthy volunteers (HV) and patients with rheumatoid arthritis (RA).
- Conditions
- Inflammation, Rheumatoid Arthritis, Healthy
- Trial name
- NCT00818064
- Testing
- anti-IL-20
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Inflammation
Low Grade Inflammation in Type 1 Diabetes Children
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
- Trial name
- Coccinelle (NCT01099956)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1, Cardiovascular Diseases
Activation Innate Immune System in Type 1 Diabetes
Hyperglycemia is a well-known cardiovascular risk factor. It has also been shown that episodes of hyperglycemia increase the risk for cardiovascular diseases despite return to normoglycemia, a phenomenon termed 'glycemic or…
- Conditions
- Diabetes Mellitus, Type 1, Cardiovascular Diseases, Innate Immune System, Inflammation
- Trial name
- NCT03441919
- Testing
- PET-CT (positron emission tomography - computer tomography), Blood drawn
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Multiple Sclerosis
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis.
- Trial name
- NCT00432900
- Testing
- [(11)C]PBR28
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation