Clinical trials: Autoimmunity
Atopy, Primary Immunodeficiency
NIAID Centralized Sequencing Protocol
Background: Genetic testing called "sequencing" helps researchers look at DNA. Genes are made of DNA and are the instructions for our bodies to function. We all have thousands of genes.
- Conditions
- Atopy, Primary Immunodeficiency, Autoimmunity, Autoinflammation
- Trial name
- NCT03206099
- Where
- 2 sites in United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Immune System Diseases, Autoimmunity
A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers
The goal of this clinical trial is to test safety of the investigational product in healthy volunteers. The main questions it aims to answer is when HIB210 is administered as multiple doses, is it: 1. Safe 2. Well tolerated 3.
- Trial name
- NCT05928585
- Testing
- HIB210
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HI-Bio, A Biogen Company
Diabetes, Celiac Disease
Gfree - For Improved Blood Sugar and Reduced Inflammation.
The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes.
- Conditions
- Diabetes, Celiac Disease, Autoimmunity, Metabolic Disease
- Trial name
- NCT05894746
- Testing
- gluten-free, probiotic, gluten
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Autoimmunity, Dry Eye Syndrome
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome
Ocular surface disease, especially dry eye and scleritis, commonly affects patients with autoimmune diseases. Ocular surface immune cells are increased in autoimmune disease; however the full subset of immune cells activated is…
- Trial name
- NCT02715323
- Testing
- Cross-sectional study
- Where
- Singapore
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Down Syndrome, Polyendocrinopathies, Autoimmune
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
This study plans to learn more about Down syndrome. The investigators think there is a different level of the AIRE gene in individuals with Down syndrome.
- Conditions
- Down Syndrome, Polyendocrinopathies, Autoimmune, Respiratory Tract Infections, Autoimmunity
- Trial name
- NCT02421276
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Th17 Helper Immune Cells, Autoimmunity
Salt and TH-17 in Healthy Human Subjects
The overall goal of this study is to evaluate the association between sodium and TH17 cells in human subjects. The subjects will have levels of TH-17 and various hormones measured on low salt diet, low salt diet with intravenous…
- Conditions
- Th17 Helper Immune Cells, Autoimmunity, Salt Intake, Sodium Chloride
- Trial name
- NCT02261688
- Testing
- Low salt diet, Low salt diet + IV normal saline, Liberal salt diet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University
Thyroid, Infertility
Thyroid Autoimmunity and Reproductive Failure in Danish Women
The present Ph.D.-study investigates the mechanisms behind the association between thyroid autoimmunity and reproductive failure.
- Conditions
- Thyroid, Infertility, Autoantibodies, Autoimmunity
- Trial name
- NCT02912442
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Periodontitis, Rheumatoid Arthritis, Autoimmunity,
Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease
The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.
- Trial name
- NCT02577679
- Where
- Taiwan
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Beta-cell Autoimmunity
Insulin-free Cow Milk Formula in Prevention of Type 1 Diabetes Associated Autoimmunity - FINDIA Pilot Study
The purpose of this study is to determine whether weaning to whey-based hydrolysed formula or essentially bovine insulin free whey-based FINDIA formula instead of standard cow's milk based formula is effective in the prevention…
- Trial name
- FINDIA (NCT01055080)
- Testing
- Cow's milk formula
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare