Clinical trials: Autoinflammatory Diseases
Behçet
Assessment of Endocan Serum Levels in Patients With Behcet Disease
The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.
- Trial name
- NCT03853135
- Testing
- measurement of serum endocan
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Benha University
Healthy Volunteers, Cryopyrin Associated Periodic Syndrome
Safety and Tolerability, Pharmacokinetic and Pharmacodynamic Study With IZD334
This is a first in human (FIH), single-centre, double -blind, randomised, cross-over, SAD followed by a MAD study of IZD334 conducted in healthy adult participants as well as an open-label cohort in adult patients with CAPS.
- Trial name
- NCT04086602
- Testing
- IZD334
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Inflazome UK Ltd
Behçet's Disease
The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease
Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for…
- Trial name
- NCT01720628
- Testing
- serum levels of angiogenin, bFGF, VEGF
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Turkish Ophthalmology Society
Behçet's Disease
MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE
Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly…
- Trial name
- NCT01780363
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cukurova University
Familial Mediterranean Fever (FMF )
Physical Activity in Adolescents With Familial Mediterranean Fever
Familial Mediterranean Fever (FMF) is one of the most common autoinflammatory rheumatic diseases in childhood. Problems such as joint pain, muscle weakness, decreased aerobic capacity, and fatigue seen in children and adolescents…
- Trial name
- NCT06974942
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Familial Mediterranean Fever
Inflammatory Proteins in Familial Mediterranean Fever During Attack and Remission
Familial Mediterranean fever (FMF) is a genetic disease, caused by mutations in the FMF gene, entitled MEFV. The disease is characterized by painful attacks of inflammation in sites lined by serous membranes (e.g.
- Trial name
- NCT00323440
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Rheumatoid Arthritis (RA, Ankylosing Spondylitis
Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases
Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk.
- Conditions
- Rheumatoid Arthritis (RA, Ankylosing Spondylitis, Psoriatic Arthritis, Reactive Arthritis (ReA)
- Trial name
- NCT07329556
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Healthy Volunteers
A Dose-Block Randomized, Placebo Controlled (Double-blind), Active Controlled(Open-label), Dose-escalation Study
The study design of this trial is a Dose-Block Randomized, Placebo controlled (Double-blind), Active Controlled(Open-label), Dose-escalation.
- Trial name
- NCT02175056
- Testing
- HL2351, Kineret(Anakinra)
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Handok Inc.
Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria
Circadian Rhythm Deregulation in Patients With CAPS
Circadian rhythms are characterized by the physiology's adaptation to the alternation of day and night, enabling to adapt to the environment. These rhythms are generated by a molecular clock within each cell.
- Conditions
- Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria, Muckle-Wells Syndrome, CINCA Syndrome
- Trial name
- ICARUS (NCT06544018)
- Testing
- Genetic analysis of NLRP3, Circadian rhythm measurement, Saliva sampling
- Where
- 6 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Behcet Syndrome
Evaluation of Serum Follistatin-Like Protein 1 Levels in Behcet's Disease and Its Association With Disease Activity
Behçet's disease (BD) is a multi-system auto inflammatory disorder with vasculitic features. The exact etiological of BD is still obscure, although environmental and genetics factors have been found to be involved in disease…
- Trial name
- NCT06730958
- Testing
- serum Follistatin-like protein 1
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Takayasu Arteritis, Behçet's Disease
Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
Systemic vasculitis refers to a group of rare diseases characterized by inflammation of blood vessel walls, which may cause ischemia and structural damage in various organs.
- Conditions
- Takayasu Arteritis, Behçet's Disease, Healthy Controls
- Trial name
- NCT07276087
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ÖZLEM NUR TOK YAMAN
Rheumatic Diseases, Adult Onset Still Disease
Rheumatology Patient Registry and Biorepository
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
- Conditions
- Rheumatic Diseases, Adult Onset Still Disease, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT04402086
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Behçet Disease
Serum EBI-3 Protein Levels in Behçet's Disease
This cross-sectional study aims to evaluate serum Epstein-Barr virus-induced gene 3 (EBI-3) protein levels in patients with Behçet's disease compared with healthy controls.
- Trial name
- NCT07845162
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sleep Quality, Behçet Disease
The Effect of Music on Sleep Quality in Behçet's Patients
The aim of this study was to evaluate effect of music on sleep quality in patients with Behçet's disease. The population of the study consists of behçet patients who applied to the Rheumatology outpatient clinic of Medical…
- Trial name
- NCT05715294
- Testing
- Music Application
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Behcet Disease
Evaluation of Voice in Behcet's
Behçet's disease (BD) is a systemic inflammatory condition of unknown origin with no definite aetiopathogenetic pathways accepted worldwide.
- Trial name
- NCT06836817
- Testing
- 1-Laryngyscopic examination 2-Acoustic analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Colonoscopy, Polyp of Colon
Does the Cap Increase the Finding of Polyps When Water Exchange Colonoscopy is Used
This is a study to compare two different, but normally, used methods of colonoscopy in patients that require a routine or repeat colonoscopy.
- Trial name
- ASGE (NCT03566615)
- Testing
- CAP-straight, CAP-daisy, water
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 1,630 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Immunodeficiency, Autoimmune Diseases
SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION
The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system…
- Conditions
- Immunodeficiency, Autoimmune Diseases, Autoinflammatory Syndrome, Allergy
- Trial name
- SAID (NCT06248957)
- Testing
- Immunomodulation
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Behcet's Disease
The Role of Rosuvastatin on Vascular Involvement in Behçet's Disease
Behçet's Disease(BD) is a systemic inflammatory vasculitis, which affects all types and sizes of vessels. Statins display numerous effects often independent of the well-established lipid-lowering effects that may be of benefit in…
- Trial name
- NCT04328064
- Testing
- Rosuvastatin calcium 40mg
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Familial Mediterranean Fever, MEFV Gene Mutation
Characterization of a Functional Test for Mediterranean Family Fever Screening - 2
Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is caused by mutations in the MEFV gene, which encodes variants of the Pyrine inflammasome.
- Trial name
- DEPIST-FMF 2 (NCT04478409)
- Testing
- one additional blood sample during a planned blood test
- Where
- 8 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon