Clinical trials: Autologous Stem Cell Transplantation
Breast Cancer, Postsurgical Acquired Absence of Organ
Non-contrast Magnetic Resonance Angiography in Deep Inferior Epigastric Perforator Flap Breast Reconstruction Planning
The aim of this study is to evaluate the efficacy and safety of contrast-free magnetic resonance angiography (MRA) for deep inferior epigastric perforator flap planning.
- Trial name
- NCT06061835
- Testing
- Non-contrast MRA in preoperative perforator vessels mapping for deep inferior epigastric perforator (DIEP) flap breast reconstruction planning., CTA with iodine contrast in preoperative perforator vessels mapping for deep inferior epigastric perforator (DIEP) flap breast reconstruction planning.
- Where
- 2 sites in Russia
- Volunteers
- 135 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Colorectal Cancer, Liver Metastases
Carcinoembryonic Antigen-loaded Dendritic Cells in Advanced Colorectal Cancer Patients
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients.
- Trial name
- NCT00228189
- Testing
- CEA-loaded dendritic cell vaccine
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Primary Central Nervous System Lymphoma
MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma
The purpose of this study is to evaluate the efficacy and safety of chemotherapy with MT-R followed by autologous stem cells transplantation in newly-diagnosed primary central nervous system lymphoma.
- Trial name
- NCT02399189
- Testing
- R-MT followed by auto-HSCT
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Jun Zhu
Cerebral Palsy
Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).
The purpose of this study is to compare the safety and effectiveness of two types of stem cells,(either banked cord blood or bone marrow), in children between the ages of 2 to 10 years with CP.
- Trial name
- ACT for CP (NCT01988584)
- Testing
- umbilical cord blood (hUCB) cells, bone marrow derived mononuclear cells (BMMNCs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiomyopathy
Characteristics of Patients With Amyloidosis & Heart Failure Being Evaluated for a Heart Transplant
The purpose of this study is to describe the characteristics of patients with amyloidosis and severe heart failure being evaluated for cardiac and stem cell transplantation.
- Trial name
- NCT00456040
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Chronic Renal Failure, Polycystic Kidney Disease
Mesenchymal Stem Cells Transplantation in Patients With Chronic Renal Failure Due to Polycystic Kidney Disease
This study was designed to provide confirmation of safety of mesenchymal stem cells (MSCs) therapy in chronic renal failure due to autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT02166489
- Testing
- Intravenous injection autologous mesenchymal stem cells
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Oropharyngeal Dysphagia
Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia
The primary objective of this double-blind, randomized, placebo-controlled, multicenter clinical trial is to evaluate the safety of AMDC-GIR during the 24 months following 2 consecutive treatments of tongue dysphagia in male and…
- Trial name
- REVIVE (NCT05421689)
- Testing
- Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR)
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of California, Davis
Recurrent Implantation Failure
hCG-activated PBMC-therapy in RIF Patients
Despite the many research done in the field of infertility and in vitro fertilization (IVF), more than half of the embryos transmitted in the IVF and intracytoplasmic sperm injection (ICSI) do not implant successfully.
- Trial name
- NCT03267797
- Testing
- Peripheral Blood Monouclear Cell, Phosphate Baffer Saline
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SCARM Institute, Tabriz, Iran
Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Busulfan and Etoposide Followed by Peripheral Blood Stem Cell Transplant and Low-Dose Aldesleukin in Treating Patients With Acute Myeloid Leukemia
This phase II trial studies the side effects and how well giving busulfan and etoposide followed by peripheral blood stem cell transplant (PBSCT) and low-dose aldesleukin works in treating patients with acute myeloid leukemia…
- Conditions
- Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT00003875
- Testing
- busulfan, etoposide, aldesleukin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer
LYL273 for Patients With Relapsed or Refractory mCRC
This is a Phase 1/2 open-label, multicenter study evaluating the safety and efficacy of LYL273 in participants with relapsed or refractory metastatic colorectal cancer.
- Trial name
- CARABiNER (NCT05319314)
- Testing
- LYL273
- Where
- 5 sites in United States
- Volunteers
- 155 people
- Sponsor
- Lyell Immunopharma, Inc.
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Hematopoietic/Lymphoid Cancer, Acute Myeloid Leukemia
Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this clinical research study is to learn about the safety and tolerability of 3 different doses of CD33-CAR-T…
- Trial name
- NCT03126864
- Testing
- Leukapheresis, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Parkinson's Disease
Mesenchymal Stem Cells Transplantation to Patients With Parkinson's Disease
The study is a phase I/II trial designed to establish the safety and efficacy of intravenous administration of autologous bone marrow derived mesenchymal stem cells to patients with Parkinson's disease.
- Trial name
- NCT01446614
- Testing
- bone marrow derived mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Metastatic Pancreatic Cancer
Direct Tumor Injection KLH-Pulsed Dendritic Cells in Unresectable Pancreatic Cancer
This research study uses radiation or a gene therapy agent, TNFerade in addition to a dendritic cell vaccine in patients with locally advanced or low volume metastatic pancreatic cancer.
- Trial name
- NCT00868114
- Testing
- KLH-pulsed autologous dendritic cell vaccine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Leo W. Jenkins Cancer Center
Kidney Cancer
Phase II Study of a B7-1 Gene-Modified Autologous Tumor Cell Vaccine and Systemic IL-2
RATIONALE: Vaccines made by inserting a laboratory-treated gene into a person's tumor cells may make the body build an immune response to kill tumor cells.
- Trial name
- NCT00031564
- Testing
- Interleukin-2, B7-1
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Heart Failure
Autologous Atrial Appendage Derived Cells in the Treatment of Heart Failure
This study aims to evaluate the safety and clinical feasibility of epicardially delivered autologous atrial appendage micrografts in the treatment of heart failure.
- Trial name
- NCT02672163
- Testing
- CABG surgery, AADC therapy
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Helsinki University Central Hospital
Multiple Myeloma
Auto-Allo Tandem Stem Cell Transplantation for Patients With Multiple Myeloma
The present study will be a multicenter, prospective phase II-study investigating safety and efficacy of the combination of auto-allo tandem stem cell transplantation in patients with multiple myeloma and age of >_60 years…
- Trial name
- NCT00777998
- Testing
- Auto-Allo Tandem SCT and maintenance therapy with Thalidomide/ DLI, auto-auto Tandem stem cell transplantation and maintenance therapy with Thalidomide
- Where
- 20 sites in Germany
- Volunteers
- 221 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Severe Chronic Ischemic Heart Disease
Patients with advanced coronary artery disease usually undergo incomplete myocardial revascularization due to the extension and diffuseness of the disease, with very poor distal arterial beds unsuitable for direct…
- Conditions
- Chronic Ischemic Heart Disease, Coronary Artery Disease, Angina Pectoris
- Trial name
- MiHeart (NCT01727063)
- Testing
- Cell Therapy
- Where
- Brazil
- Volunteers
- 143 people
- Sponsor
- Ministry of Health, Brazil
Urinary Incontinence, Stress
Autologous Muscle Derived Cells Female Stress Urinary Incontinence Clinical Study
This is a clinical trial to study the safety and effectiveness of Autologous Muscle Derived Cells for Urinary Sphincter Repair (AMDC-USR) for the treatment of female stress urinary incontinence (SUI).
- Trial name
- NCT01382602
- Testing
- AMDC-USR
- Where
- 10 sites in Canada, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Cook MyoSite
Multiple Myeloma, Amyloidosis
Study of Captisol Enabled Melphalan and Pharmacokinetics for Patients With Multiple Myeloma or Light Chain Amyloidosis That Are Receiving an Autologous Transplant.
Captisol Enabled Melphalan, is a new formulation of the standard of care melphalan chemotherapy that in packaged in an inactive substance that is believed to help the chemotherapy be more stable (meaning that it doesn't lose its…
- Trial name
- NCT02909036
- Testing
- Melphalan, Pegfilgrastim, Autologous Hematopoietic Progenitor Cell Transplant
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Memorial Sloan Kettering Cancer Center