Clinical trials: Autologous Transplantation
Pterygium of Both Eyes
Comparative Study of Muc5ac and Muc2 Mucins in Tear Film Concentration in Surgical Treated Pterygia Patients
To identify and compare the differences in the concentration of the Muc2 and Muc5AC mucins in tear film in patients who underwent pterygium surgery using amniotic membrane transplantation and conjunctival autograft surgery.
- Trial name
- NCT04385446
- Testing
- Amniotic membrane transplantation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Keloid, Autologus Adipose Derived Stem Cells
Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids.
Keloids are the most common disfiguring skin disorder affecting colored population with a prevalence of upto 16%. Autologous adipose derived stem cells have been found to have potential therapeutic benefits however limited…
- Conditions
- Keloid, Autologus Adipose Derived Stem Cells, Feasibility, Safety
- Trial name
- NCT04553159
- Testing
- Autologous adipose derived stem cells
- Where
- Uganda
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Makerere University
Antibiotic Treatment
Restoration of Antibiotics Related Infant Microbiota Perturbations by Autologous Fecal Transplant
Antibiotics are lifesaving therapeutic drugs which have been used by adults, children, and infants alike for decades. There is an increase in global use of antibiotics over the course of lifetime and earlier in lifetime, with…
- Trial name
- aFMT-babies (NCT06609980)
- Testing
- autologous fecal matter transplant
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Pancreatitis, Diabetes Mellitus
Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis
Randomized pilot trial of patients (n=30) undergoing Total Pancreatectomy and Islet AutoTransplant (TPIAT). Patients with islet harvest of greater than 5000 islet equivalents/kg body weight will be randomized to receive a portion…
- Conditions
- Chronic Pancreatitis, Diabetes Mellitus, Islet Cell Transplantation
- Trial name
- iSite (NCT03779139)
- Testing
- Intrahepatic islets and islets in the omental pouch, Intrahepatic islets alone, Normal Volunteers
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Myeloma Multiple
Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma
To increase the conversion rate from MRD-positive to MRD-negative CR in patients with newly diagnosed multiple myeloma (NDMM) receiving post-transplant maintenance therapy with belantamab mafodotin plus lenalidomide.
- Trial name
- NCT05091372
- Testing
- Belantamab mafodotin, Lenalidomide
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Diabetes Mellitus, Insulin-Dependent
Safety and Efficacy of Mesenchymal Stem Cells in Newly-diagnosed Type 1 Diabetic Patients
Type 1 diabetes mellitus results from the autoimmune destruction of the insulin producing pancreatic β-cells. The autoimmune response begins months or even years before the presentation of hyperglycemic symptoms.
- Trial name
- NCT01322789
- Testing
- Intravenous Mesenchymal stem cell infusion
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Apicomarginal Defects
Evaluate the Effect of Graft and Membrane on Healing of Apicomarginal Defects
This study will compare the effect of guided tissue regeneration using a mixture of autograft and PRF covered with a collagen membrane as compared to the membrane alone in the healing of apicomarginal defects.
- Trial name
- NCT04366700
- Testing
- Periapical surgery with autograft and collagen membrane, Periapical surgery with collagen membrane
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Increase Success Rate of Tooth Transplantation
Use of CBCT-based Tooth Replica in Tooth Autotransplantation to Improve the Outcome of Tooth Replacement in Children
The aim of this study lies in comparing the outcome of the proposed technique in a large sample size group to the outcome of the conventional tooth autotransplantation method and to provide sufficient evidence for improving the…
- Trial name
- NCT02464202
- Testing
- stereolithography tooth replica
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pterygium
ICG Angiography in Amniotic Membrane Graft and Conjunctival Autograft After Pterygium Excision
To evaluate graft vascularization and compare the vascularization patterns of conjunctival autografts with amniotic membrane grafts to better understand the factors involved in pterygium recurrence.
- Trial name
- NCT00383825
- Testing
- Anterior segment indocyanine green angiography
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baskent University
Adipocytes, Autografts
3D Facial Scanning for Evaluating Autologous Fat Grafting in Craniofacial Deformities
Treatment of craniofacial deformities is a significant topic in oral and maxillofacial surgery, and autologous fat grafting has become one of the main methods for treating facial concave deformities.
- Conditions
- Adipocytes, Autografts, Imaging, Three-Dimensional / Methods
- Trial name
- NCT06306326
- Testing
- 3dMD technology
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Decayed Teeth
3D Printed Donor Tooth Replica in Autotransplantation of Teeth
3D printed replicas of the donor tooth can reduce extraoral time during the autotransplantation of teeth, which can reduce dehydration and manipulation of periodontal tissue of the donor tooth, thus possibly increasing the…
- Trial name
- NCT04933409
- Testing
- 3D printed replica of the donor tooth, Conventional Autotransplantation of tooth
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- College of Medical Sciences Teaching Hospital. Nepal
Gingival Recessions
Evaluation of the Clinical Efficacy of De-Epithelialized Free Gingival Graft in the Treatment of Gingival Recessions
The aim of this study is to evaluate the clinical effectiveness of three techniques used in combination with the tunnel method for the treatment of multiple gingival recessions: subepithelial connective tissue graft (SCTG Group)…
- Trial name
- NCT07100808
- Testing
- Using the tunnel technique in the treatment of gingival recession
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Implant Site Reaction, Dental Implantation
BMAC Loaded Collagen Jumping the Gap Around Immediate Implants
The present study aims to evaluate the effect of utilization of BMAC/ collagen on marginal bone changes around immediate implants in the esthetic zone of maxilla.
- Trial name
- NCT05817526
- Testing
- BMAC/ collagen, Autograft harvesting from chin
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pterygium
Comparison of Glue With Sutures for Pterygium Surgery
Pterygium excision surgery involves excising the abnormal growth from the cornea and filling the defect with a conjunctival (white of the eye) graft from the superior part of the eye.
- Trial name
- NCT00326560
- Testing
- Pterygium excision and conjunctival autograft
- Where
- New Zealand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wellington Hospital
Rhizarthrosis
Biological Characterization Study of an Autograft Nanofat (Nanocarabio)
Rhizarthrosis (trapeziometacarpal osteoarthritis) is the most common primary osteoarthritis of the hand, and a source of major functional impact, as it affects the thumb.
- Trial name
- Nanocarabio (NCT05915962)
- Testing
- collecting a Nanofat-type microfat autograft
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Bone Graft
Simultaneous Implant Placement With Autogenous Bone Ring
This study is aiming to evaluate bone gain and secondary stability in autogenous bone ring technique using trephine bur compared to control group of sticky bone.
- Trial name
- RCT (NCT05403112)
- Testing
- Bone ring with open sinus lifting
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Omar Saleh Ahmed Bassed
Atrophic Maxilla
Assessment of Bone Quality and Quantity for Three Dimensional Bone Augmentation for Maxilla Using Patient Specific Titanium Meshes Loaded With Bone Marrow Aspirate Mixed With Xenograft Versus Xenograft Mixed With Autografts Only: a Randomized Clinical Trial
Assessment of bone quality and quantity for three dimensional bone augmentation for maxilla using titanium meshes loaded with bone marrow aspirate mixed with xenograft versus xenograft mixed with autografts only
- Trial name
- NCT05400044
- Testing
- Three dimensional maxillary bone augmentation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
ACL Tear
Anterior Cruciate Ligament (ACL) Reconstruction With Bone Tendon Bone Autograft With Versus Without Internal Bracing
There is no consensus regarding the best surgical management of primary ACL tears. Recent evidence suggests that internal brace augmentation may increase load failure and therefore stabilize the graft in-situ at the time of ACL…
- Trial name
- NCT05532189
- Testing
- ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Hodgkin Lymphoma, Refractory Hodgkin Lymphoma
Treatment Strategy for Relapsed/Refractory Hodgkin Lymphoma
The choice of the best second-line therapy in patients with high LH R/R risk, it is a niche of knowledge not covered at the moment, especially the role of Brentuximab (BV) plus PD-1 blockade and auto-HSCT.
- Conditions
- Hodgkin Lymphoma, Refractory Hodgkin Lymphoma, Relapsed Hodgkin's Disease, Adult
- Trial name
- NCT05595447
- Testing
- Brentuximab Vedotin 50 MG [Adcetris]
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio
Graft Function
Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoperative Parathyroid Insufficiency (IMIPAT Study)
Parathyroid insufficiency is a common complication in thyroid surgery and occurs in 6.6 to 24%. Up to 4.4% suffer from permanent hypoparathyroidism requiring life-time substitution of calcium and vitamin D in order to maintain a…
- Trial name
- IMIPAT (NCT07516990)
- Testing
- Intramuscular injection of mashed parathyroid tissue into the brachioradial muscle during thyroid surgery
- Where
- 2 sites in Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna