Clinical trials: Autologous Transplantation
Multiple Myeloma and Plasma Cell Neoplasm
Treated T Cells Followed by a Stem Cell Transplant in Treating Patients With Multiple Myeloma
RATIONALE: Giving chemotherapy followed by treated T cells before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or by killing them.
- Trial name
- NCT00938626
- Testing
- anti-CD3 x anti-CD20 bispecific antibody-armed activated T cells, autologous hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Multiple Myeloma
Pharmacokinetic Study of Propylene Glycol-Free Melphalan HCl for Myeloablative Conditioning in Multiple Myeloma Patients Undergoing Autologous Transplantation
This study is a single-center, open-label study of high-dose Melphalan HCl (hydrochloric acid) for injection (propylene glycol-free Melphalan) conducted in 24 patients, who have symptomatic multiple myeloma and qualify for…
- Trial name
- NCT02669615
- Testing
- Melphalan HCl for injection (propylene glycol free)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical College of Wisconsin
Leukemia, Lymphoblastic, Acute, Leukemia, Myeloid Acute
Phase I, Dose Escalation Study of Decitabine
Decitabine is a hypomethylating agent that has shown significant anti-leukemic effect in Myelodysplastic Syndrome (MDS) and Acute Myeloblastic Leukemia (AML).
- Conditions
- Leukemia, Lymphoblastic, Acute, Leukemia, Myeloid Acute, Hematopoetic Myelodysplasia
- Trial name
- NCT02264873
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Wound Dehiscence
Flipped Autograft for Treating Surgical Wound Dehiscence
This case report describes a novel technique for management of peri-implant wound dehiscence that involves using auto graft from the same surgical site to seal the dehiscence defect.
- Trial name
- NCT05513222
- Testing
- flipped autograft
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Patient's Outcome Prognostic Factors
Clinical Characteristics and Outcomes of Relapsed Follicular Lymphoma After Autologous Stem Cell Transplantation at Rituximab Era
Introduction High dose chemotherapy followed by Autologous Stem Cell Transplantation (ASCT) is a therapeutic option in follicular Lymphoma after first line treatment failure.
- Trial name
- NCT03663894
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Hospices Civils de Lyon
Hodgkin's Lymphoma, Multiple Myeloma
Assessment of Impact Nutritional Program During Autologous Stem Cell Transplant
Nestle Impact has shown efficacy in multiple surgical trials in relation to improving hospital length of stay and infection rate.
- Conditions
- Hodgkin's Lymphoma, Multiple Myeloma, Non-Hodgkin's Lymphoma
- Trial name
- NCT01699581
- Testing
- Nestle Impact Advanced Recovery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Greg Monohan
Amyotrophic Lateral Sclerosis (ALS)
Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS
This is a multi-center, randomized, double blind, placebo controlled study to evaluate the safety and efficacy of autologous (self) transplantation of Neurotrophic factors-secreting Mesenchymal Stromal Cells (MSC-NTF, NurOwn™) in…
- Trial name
- NurOwn (NCT02017912)
- Testing
- Nurown MSC-NTF cells
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Brainstorm-Cell Therapeutics
Chemotherapy-Induced Nausea and Vomiting (CINV)
Evaluating the Feasibility and Acceptability of Inhalation Aromatherapy for Patients Undergoing Autologous Haematopoietic Stem Cell Transplant (HSCT)
The goal of this clinical trial is to evaluate whether aromatherapy inhaler sticks can reduce nausea and vomiting in patients receiving chemotherapy as part of their stem cell transplant treatment.
- Trial name
- Aroma-CINV (NCT07209501)
- Testing
- Aromatherapy inhaler
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
Multiple Myeloma
Phase II Study of Daratumumab Pre-Mobilization and Post-ASCT in Multiple Myeloma
This study will use the drug daratumumab in patients who did not achieve at least a very good partial response (VGPR) and are already planned to have an Autologous Stem Cell Transplant (ASCT).
- Trial name
- NCT04230031
- Testing
- Daratumumab
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Lymphoma, Small Intestine Cancer
High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma
RATIONALE: Giving chemotherapy before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or by killing them.
- Trial name
- NCT00669812
- Testing
- carmustine, cyclophosphamide, cytarabine
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cancer Research UK
Acute Myocardial Infarction
Treatment of Myocardial Infarction With Bone Marrow Derived Stem Cells
The aim of the study is to investigate whether infusion of autologous bone marrow derived stem cells can improve cardiac function in the aftermath of a myocardial infarction.
- Trial name
- NCT00275977
- Testing
- Coronary catherization and stem cell infusion
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Nodal T-follicular Helper Cell Lymphoma
Linperlisib-based Treatment Regimen in Newly Diagnosed Nodal T-follicular Helper Cell Lymphoma (nTFHL)
This study is conducted to evaluate the efficacy and safety of linperlisib combined with CHOP regimen followed by autologous hematopoietic stem cell transplantation and linperlisib monotherapy maintenance for newly diagnosed…
- Trial name
- NCT06347653
- Testing
- linperlisib combined with CHOP regimen
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Peking University
Hodgkin Lymphoma
Study of RAD001 in Patients With Relapsed/Refractory Hodgkin Lymphoma That Has Progressed After High-dose Chemotherapy and Autologous Stem Cell Transplant and/or After Gemcitabine- or Vinorelbine- or Vinblastine-based Treatment.
This study will assess RAD001 in patients with refractory or relapsed Hodgkin Lymphoma that has progressed after high-dose chemotherapy and Autologous Stem cell transplant and/or after gemcitabine- or vinorelbine- or…
- Trial name
- NCT01022996
- Testing
- Everolimus (RAD001)
- Where
- 16 sites in United States
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Multiple Myeloma
Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT)
This study will see how long it takes for white blood cell counts to return to normal in people with multiple myeloma (MM) who receive plinabulin and pegfilgrastim after undergoing an autologous hematopoietic stem cell transplant…
- Trial name
- NCT05130827
- Testing
- Plinabulin
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Myeloma
A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE
This is a phase 2A multi-centre, open label, pilot study of pembrolizumab added to the standard first-line therapy of cyclophosphamide, bortezomib and dexamethasone (CyBorD) in newly diagnosed patients with multiple myeloma that…
- Trial name
- NCT04258683
- Testing
- Pembrolizumab
- Where
- 4 sites in Canada
- Sponsor
- Canadian Myeloma Research Group
Necrosis
Treatment of Osteonecrosis of the Femoral Head by Bone Marrow Transplantation
Aseptic non traumatic osteonecrosis (ON) is a painful disorder of the hip which often leads, in its final stage, to femoral head collapse and subsequent total hip replacement.
- Trial name
- NCT00821470
- Testing
- core decompression, Bone marrow implantation into the necrotic lesion
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Erasme University Hospital
Non-hodgkin Lymphoma
Venetoclax in Combination With BEAM Conditioning Regimen for ASCT in Non-Hodgkin Lymphoma
The purpose of this study is to determine the correct dose and safety of adding a new cancer drug, Venetoclax, to a standard combination of chemotherapy drugs used prior to Autologous stem cell transplant (ASCT) in participants…
- Trial name
- NCT03713580
- Testing
- Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Disease
Mensenchymal Stem Cell (MSC) Included in OrthADAPT Membrane for Rotator Cuff Tears Repair
Surgical reconstructive procedures for rotator cuff tears present a number of limitations. The few studies in which the repair integrity is evaluated, have shown the existence of a high rate of reruptures in spite of the fact…
- Trial name
- msctendonrep (NCT01687777)
- Testing
- Mesenchymal Stem Cells (MSCs), OrthADAPT
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Hospital San Carlos, Madrid
Crohn's Disease
Autologous Stem Cell Transplant for Refractory Crohn's Disease
Crohn's disease is an 'auto-immune' disorder of the gut. In this condition the body's own immune system is fighting its gut and causing inflammation and other symptoms.
- Trial name
- NCT02676622
- Testing
- mobilization of stem cells to prepare for Leukapheresis, Leukapheresis- Collection of stem cells, Preparative regimen 4-6 weeks after Leukapheresis
- Sponsor
- Nationwide Children's Hospital
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