Clinical trials: Autologous Transplantation
Crohn Disease, Perianal Fistula
Adipose Tissue in Crohn´s Disease Fistulas
Present study investigated the efficacy of injection of freshly collected autologous adipose tissue into perianal fistulas in patients with Crohn's disease.
- Conditions
- Crohn Disease, Perianal Fistula, Tissue Transplantation
- Trial name
- NCT03803917
- Testing
- Injection with freshly collected autologous adipose tissue
- Volunteers
- 21 people
- Sponsor
- Lilli Lundby
Congenital Heart Disease (CHD)
Autologous Thymus Transplant in Children With Congenital Heart Disease: A Pilot Study
This pilot study will look at whether putting back a child's own thymus tissue during heart surgery is safe and may help support the immune system in children with congenital heart disease (CHD).
- Trial name
- ATTT (NCT07799259)
- Testing
- Autologous Thymus Transplant
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Non-Hodgkin's Lymphoma (NHL)
Mega-CHOEP: Conventional Chemo Vs HD Chemo Followed by Auto SCT in Younger Pts With Aggressive Non-Hodgkin's Lymphoma
According to amendment 3 this study addresses the question if intensification of administration of rituximab in standard treatment for patients with newly diagnosed aggressive B-Non Hodgkin Lymphoma (B-NHL) and high risk (aaIPI 2…
- Trial name
- NCT00129090
- Testing
- R-CHOEP 14 with 12x Rituximab
- Where
- Germany
- Volunteers
- 450 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML)
High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) study is the first prospective real-world cohort of hematologic diseases and transplantation in the Qinghai-Tibet Plateau.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML), Leukemias, Acute Myeloid, Myeloid Leukemias, Acute
- Trial name
- HALO-SCT (NCT07205523)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yigeng Cao,MD,PhD
Significant Bone Defect in the Orbit
Efficiency of 3D-printed Implant Versus Autograft for Orbital Reconstruction (TOR-3D)
Two scenarios may result in significant bone defect in the orbit: surgical oncology (meningioma, cancers of the upper aerodigestive tract) or severe trauma.
- Trial name
- TOR-3D (NCT03608280)
- Testing
- Bone autograft, Orbital reconstruction by 3D-printed porous titanium implant
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Hospices Civils de Lyon
Tear; Knee, Cartilage, Articular
Autologous Chondrocyte Transplantation For Articular Cartilage Regeneration
The purpose of this study is to assess safety and efficacy of autologous chondrocyte implantation delivered arthroscopically into chondral lesions of the knee using clinical, biochemical, and MRI outcomes.
- Trial name
- NCT01503970
- Testing
- Arthroscopic matrix encapsulated chondrocyte implantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Amyloidosis; Systemic
Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients
This is a single arm, open label study designed to evaluate the safety and efficacy of propylene glycol-free melphalan hydrochloride in patients with AL amyloidosis.
- Trial name
- NCT02994784
- Testing
- Propylene Glycol-Free Melphalan Hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Medical Center
Peripheral T-cell Lymphoma (Not Otherwise Specified), Angioimmunoblastic T-cell Lymphoma
Study of Bortezomib and Panobinostat in Treating Patients With Relapsed/Refractory Peripheral T-cell Lymphoma or NK/T-cell Lymphoma
The purpose of this study is to determine whether intravenous Bortezomib combined with oral Panobinostat (LBH589) are effective in treating adult patients with relapsed/refractory peripheral T-cell lymphoma or NK/T-cell lymphoma…
- Conditions
- Peripheral T-cell Lymphoma (Not Otherwise Specified), Angioimmunoblastic T-cell Lymphoma, Extranodal NK/T-cell Lymphoma Nasal Type, Enteropathy- Type T-cell Lymphoma
- Trial name
- NCT00901147
- Testing
- panobinostat and bortezomib
- Where
- 5 sites in Malaysia, Singapore and 1 more
- Volunteers
- 25 people
- Sponsor
- Singapore General Hospital
Peripheral T Cell Lymphoma
T Cell Lymphoma -Stratified Therapy After Response to First-line Treatment-CR
This study is a multicenter, two-arm, prospective clinical trial, comprising two groups: the observation group and the autologous hematopoietic stem cell transplantation group (Auto-HSCT).
- Trial name
- T-START-CR (NCT07353840)
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Observation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Ischemic Stroke, Hemorrhagic Stroke
Safety of Autologous M2 Macrophage in Treatment of Non-Acute Stroke Patients
The purpose of this study is to determine whether M2 macrophages are safe and feasible in the treatment of non-acute stroke patients
- Trial name
- NCT01845350
- Testing
- M2 macrophage introduction
- Where
- Russia
- Volunteers
- 13 people
- Sponsor
- Siberian Branch of the Russian Academy of Medical Sciences
Autologous Haemopoietic Stem Cell Transplant
Beta-glucan and Fatigue in HSCT Survivors
This is a single-center, randomized, double-blind, placebo-controlled study exploring the effects of a yeast-derived β-glucan on clinically significant fatigue among survivors of autologous HCT due to multiple myeloma.
- Trial name
- NCT05524688
- Testing
- Beta-glucan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Breast Cancer
Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous bone marrow transplantation or peripheral stem cell transplantation…
- Trial name
- NCT00002942
- Testing
- autologous bone marrow transplantation, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Wake Forest University Health Sciences
B-cell Non Hodgkin Lymphoma
ARTA-based Chemo-free Bridging/Maintenance Therapy in CAR-T Treatment for High-Risk R/R B-NHL Ineligible for HDCT and ASCT
This is a single-center, open-label, prospective study enrolling high-risk (tumor diameter > 4 cm) relapsed/refractory B-NHL patients ineligible for HDCT and ASCT.
- Trial name
- NCT06646666
- Testing
- All-trans retinoic acid, zanubrutinib, radiotherapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Ruijin Hospital
Neuroblastoma
Combination Chemotherapy Followed by Stem Cell Transplant in High-risk Neuroblastoma Patients
Improvement of event free survival of high-risk neuroblastoma patients by introduction of two additional topotecan containing chemotherapy cycles into the multimodal standard treatment (induction chemotherapy, myeloablative…
- Trial name
- NB2004-HR (NCT03042429)
- Testing
- Cycles N8, N5 and N6, Cycles N5 and N6
- Where
- Germany
- Volunteers
- 360 people
- Sponsor
- University of Cologne
Multiple Myeloma
A Study to Evaluate Two Different Regimens of VELCADE in Combination With Dexamethasone, Thalidomide and Cyclophosphamide (VDT vs VDTC) in Newly Diagnosed Multiple Myeloma
The purpose of this Phase 2 randomized study is to evaluate the efficacy and safety of treatment with a regimen of VELCADE, dexamethasone, and thalidomide (VDT) or VELCADE, dexamethasone, thalidomide, and cyclophosphamide (VDTC)…
- Trial name
- NCT00531453
- Testing
- bortezomib, dexamethasone, and thalidomide, bortezomib, dexamethasone, thalidomide, and cyclophosphamide
- Where
- Austria
- Volunteers
- 98 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Knee Injuries
Efficacy and Safety of OMS103HP in Patients Undergoing Autograft Anterior Cruciate Ligament (ACL) Reconstruction
The anterior cruciate ligament (ACL) is an important stabilizer of the knee. Orthopedic surgeons replace the torn ligament during ACL reconstruction surgery.
- Trial name
- NCT00226772
- Testing
- OMS103HP, Vehicle
- Where
- 18 sites in United States, Canada
- Volunteers
- 326 people
- Sponsor
- Omeros Corporation
Multiple Myeloma, Stem Cell Transplant Complications
Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
The goal of this research study is to investigate whether a virtual, home-based, prehabilitation aerobic and resistance exercise (PARE) training program implemented 8 weeks prior to receiving autologous stem cell transplant…
- Trial name
- NCT05706766
- Testing
- PARE, Waitlist Control Group
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Lymphoma, Multiple Myeloma
Efficacy and Safety of PEG-rhG-CSF Injection for Neutrophil Reconstitution Following AHSCT in Lymphoma/Multiple Myeloma
This study evaluates the effectiveness and safety of PEG-rhG-CSF injection for the reconstruction of neutrophil cells after autologous hematopoietic stem cell transplantation in lymphoma/multiple myeloma patients.
- Trial name
- NCT06060080
- Testing
- pegylated recombinant human granulocyte-colony stimulating factor
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Yao Liu
Multiple Myeloma
Fractionated Stem Cell Infusions in Myeloma Patients Undergoing Autologous Stem Cell Transplant
Multiple myeloma is difficult to treat with only anti-cancer medicine (called chemotherapy) or radiation alone. Sometimes higher doses of chemotherapy are used but when used can also lower blood counts.
- Trial name
- NCT01416246
- Testing
- Fractionated Stem Cell Infusions
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Neoplasms, Lymphoma
Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma
This is a phase I/II study of interleukin-1, G-CSF and high dose ICE chemotherapy with autologous bone marrow transplant in patients with relapsed breast, testicular and lymphoid cancers.
- Conditions
- Breast Neoplasms, Lymphoma, Neoplasm Metastasis, Testicular Neoplasms
- Trial name
- NCT00001270
- Testing
- interleukin-1
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute (NCI)
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