Clinical trials: Autologous Transplantation
Breast Cancer
Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- CTC (NCT00005798)
- Testing
- Carboplatin, Cyclophosphamide, Thiotepa
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Multiple Myeloma
Treatment Optimization in Patients With Untreated Multiple Myeloma
This is a multicenter, randomized, blinded, 2-arm phase IIb trial that will compare the efficacy and safety of Lenalidomide maintenance after Bortezomib/Melphalan/Prednison (VMP) induction to VMP without maintenance (Placebo).
- Trial name
- GERMAIN (NCT02145598)
- Testing
- Lenalidomide
- Where
- 19 sites in Germany
- Volunteers
- 85 people
- Sponsor
- Dr. med. Lars-Olof Muegge
Multiple Myeloma
Clinical Trial Investigating the Chemotherapeutic Compound Treosulfan (Trecondi® Ideogen) in Myeloma Patients
Clinical trial investigating the chemotherapeutic compound treosulfan (Trecondi® Ideogen) in myeloma patients.
- Trial name
- TreoMel (NCT05636787)
- Testing
- Treosulfan, Melphalan
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pterygium
Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia
The purpose of this study is to determine if there is any difference in the surgical time when the surgery is performed with a graft taken from under the upper lid versus lower lid.
- Trial name
- NCT01261455
- Testing
- Location of the autograft taken following pterygium excision
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis
Observational Study in Multiple Sclerosis Patients Treated With Autologous Hematopoietic Stem Cell Transplantation
Observational prospective , multi-center study Primary objective : To gain further homogenous evidence for clinical efficacy of aHSCT in patients undergoing aHSCT for MS as primary indication.
- Trial name
- OMST (NCT04674280)
- Testing
- aHSCT
- Volunteers
- 50 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Premature Ovarian Failure
Autologous ADMSC Transplantation in Patients With POI
The primary ovarian insufficiency (premature ovarian failure, premature ovarian insufficiency, premature menopause) is a hypergonadotropic hypogonadism, that failure of the ovarian function in woman younger than 40 years.
- Trial name
- ADMSC (NCT06132542)
- Testing
- stem cell therapy
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Mongolian National University of Medical Sciences
Light Chain Deposition Disease, Primary Systemic Amyloidosis
Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis
This randomized phase III trial is studying melphalan and dexamethasone to see how well they work with or without bortezomib in treating patients with previously untreated systemic amyloidosis.
- Trial name
- NCT01078454
- Testing
- melphalan, dexamethasone, bortezomib
- Where
- 209 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Anterior Cruciate Ligament Reconstruction Rehabilitation, Strength Outcomes
Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction
This prospective observational study will compare recovery after anterior cruciate ligament reconstruction using quadriceps tendon autograft or hamstring tendon autograft.
- Conditions
- Anterior Cruciate Ligament Reconstruction Rehabilitation, Strength Outcomes, Anterior Cruciate Ligament (ACL) Reconstruction Surgery
- Trial name
- GRAFT-ACL (NCT07523854)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hacettepe University
Lymphoma
Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002461
- Testing
- filgrastim, sargramostim, carmustine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Montefiore Medical Center
Lipodystrophy
Autologous Adipose-Derived Stem Cell Transplantation in Patients With Lipodystrophy
The aim of this study is to determine the safety of the autologous transplantation of adipose-derived stem cells in the treatment of lipodystrophies.
- Trial name
- AADSCTPL (NCT00715546)
- Testing
- autologous transplantation of liposuction material enriched with adipose-derived stem cells
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
Pterygium
Assessment of Low-temperature Plasma Surgery System in Pterygium With Fibrin Glue and Conjunctival Autografts
Pterygium is a wing-shaped fibrovascular tissue that has proliferated onto the cornea. Ultraviolet radiation and hot, dusty, windy, dry, smoky environments are regarded as risk factors for pterygium .
- Trial name
- NCT03204084
- Testing
- Low-temperature Plasma Surgery System
- Volunteers
- 56 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Multiple Myeloma
Chemotherapy, Vaccine Therapy, and Stem Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Vaccines made from a person's cancer cells may make the body build an immune response to kill cancer cells.
- Trial name
- NCT00024466
- Testing
- GVAX, Autologous transplant
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Autologous Transplant Indication
GRAFted Patients' anxieTY Report
Autograft is a technique requiring several weeks of hospitalization in a protected environment and can be a source of anxiety of different natures for patients.
- Trial name
- GRAFTY (NCT03675997)
- Testing
- HAD (Hospital Anxiety and Depression) scale
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut de Cancérologie de la Loire
Multiple Myeloma, Hodgkin Lymphoma
Mozobil for Autologous Hematopoietic Stem Cell Transplantation
This prospective trial investigates the approach of G-CSF with risk-adapted Plerixafor use for stem cell mobilization in patients undergoing autologous stem cell transplantation.
- Conditions
- Multiple Myeloma, Hodgkin Lymphoma, Non-hodgkin Lymphoma
- Trial name
- HSCT (NCT07188090)
- Testing
- Plerixafor, Gcsf
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Mantle Cell Lymphoma
Bortezomib After Combination Chemotherapy, Rituximab, and an Autologous Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma
This randomized phase II trial studies how well bortezomib works when given after combination chemotherapy, rituximab, and an autologous stem cell transplant in treating patients with mantle cell lymphoma.
- Trial name
- NCT00310037
- Testing
- bortezomib
- Where
- 48 sites in United States
- Volunteers
- 151 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma
Bendamustine, Prednisone and Velcade® for First-line Treatment of Patients With Symptomatic Multiple Myeloma
The purpose of this study is to improve efficacy of treatment for patients with newly diagnosed multiple myeloma who are not eligible for high-dose chemotherapy followed by autologous stem cell transplantation by Bendamustin…
- Trial name
- BPV (NCT02237261)
- Testing
- Bendamustine, Bortezomib, Prednisone
- Where
- 15 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Heidelberg
Diffuse Large Cell Lymphoma
Rituximab, Gemcitabine and Oxaliplatin (R-GEMOX) for Refractory/Relapsed B-cell Lymphoma
The Purpose of this study is to evaluate the efficacy and the safety of R-GEMOX in refractory/relapsed patients with CD20-positive large B-cell lymphoma who are not eligible for autologous transplantation.
- Trial name
- NCT00169195
- Testing
- Gemcitabine-Oxaliplatin plus Rituximab (R-GEMOX)
- Where
- 8 sites in France
- Volunteers
- 49 people
- Sponsor
- Lymphoma Study Association
Discogenic Pain
Safety and Efficacy of PRP for Treatment of Disc Pain
This is a multi-center, randomized, controlled, double-blind clinical trial comparing hemocyte autograft (platelet rich plasma) to control injection (placebo) in subjects with reported cervical, thoracic or lumbar pain for at…
- Trial name
- NCT04064866
- Testing
- High yield pure PRP, ProPlaz PPC
- Where
- 7 sites in United States
- Volunteers
- 27 people
- Sponsor
- Neurological Associates of West Los Angeles
Wound Healing Disorder
Lipofilling for Healing of Chronic Wounds
Chronic wounds remain a therapeutic and financial challenge for physicians and the health care systems. Innovative, cheap and effective treatment methods would be of immense value.
- Trial name
- NCT05509673
- Testing
- Lipofilling (sublesional fat grafting)
- Volunteers
- 34 people
- Sponsor
- University of Witten/Herdecke
Lumbar Spinal Stenosis Secondary to Other Disease
NanOss Bioactive With Autograft and Bone Marrow Aspirate in the Posterolateral Spine
The purpose of this study is to assess lumbar fusion using nanOss Bioactive bone void filler
- Trial name
- NCT02005341
- Testing
- nanOSS, Autograft
- Sponsor
- Pioneer Surgical Technology, Inc.
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