Clinical trials: Autonomic Dysregulation
Progressive Supranuclear Palsy, Dementia With Lewy Bodies
In-Home Care for Patients With PSP and Related Disorders
Progressive Supranuclear Palsy and related disorders (PRD) are debilitating, costly, and understudied conditions. Improving access to comprehensive, specialized, in-home patient care offers the potential to minimize the downward…
- Conditions
- Progressive Supranuclear Palsy, Dementia With Lewy Bodies, Multiple System Atrophy, Corticobasal Syndrome
- Trial name
- NCT03552484
- Testing
- Home Visit Program, Usual Care/Online Survey
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Autoimmune Autonomic Ganglionopathy (AAG)
Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy
The purpose of the study is to see if administering intravenous immune globulin (IVIG) (putting immune globulin directly into your blood) helps to improve the symptoms of orthostatic hypotension (sudden fall in blood pressure…
- Trial name
- NCT01522235
- Testing
- Double blinded IVIg, Single Blinded IVIg
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital…
- Trial name
- NCT06219655
- Testing
- thoracoscopic sympathectomy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Musculoskeletal Pain, Fractures, Closed
Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures
Nearly 2 out of 10 women will sustain a distal forearm fracture throughout their lifespan.Recent longitudinal studies illustrate that as many as 1/3 of all persons who undergo closed reduction and casting for distal radius…
- Conditions
- Musculoskeletal Pain, Fractures, Closed, Distal Radius Fracture, Complex Regional Pain Syndromes
- Trial name
- NCT02957240
- Testing
- Standard Care, Motor Representation Techniques
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Autonomic Dysreflexia
Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)
This study will be investigating the effects of fesoterodine on autonomic dysreflexia (AD) in patients with spinal cord injuries (SCI).
- Trial name
- NCT02676154
- Testing
- Fesoterodine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Cardiac Disease, Syncope
Second Study on Cardio-neuromodulation in Humans
Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published.
- Conditions
- Cardiac Disease, Syncope, Syncope, Vasovagal, Sick Sinus Syndrome
- Trial name
- CardNMH2 (NCT02954666)
- Testing
- radio-frequency ablation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Imelda Hospital, Bonheiden
Covid19, Post-acute Covid-19 Syndrome
Physical Training in Patients With POTS After Covid-19
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Covid19, Post-acute Covid-19 Syndrome, Postural Orthostatic Tachycardia Syndrome
- Trial name
- POTS-ReCOV (NCT05094622)
- Testing
- Physical exercise program
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Autonomic Nervous System Disorders, Pure Autonomic Failure
Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
Pharmacologic approaches to increase levels or actions of the vasodilatory peptide angiotensin-(1-7) are currently in development for the treatment of hypertension based on findings from animal models.
- Conditions
- Autonomic Nervous System Disorders, Pure Autonomic Failure, Shy-Drager Syndrome, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT02591173
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder)
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2).
- Trial name
- NCT04439669
- Testing
- Active nrTMS and open phase
- Where
- 2 sites in Finland
- Volunteers
- 62 people
- Sponsor
- Helsinki University Central Hospital
Postural Tachycardia Syndrome
Hemodynamic Effects of Compression in POTS
When an individual with Postural Tachycardia Syndrome (POTS) stands up, their heart rate increases significantly (>30BPM) and they may experience symptoms such as lightheadedness, dizziness, shortness of breath, nausea and mental…
- Trial name
- NCT03484273
- Testing
- LifeWrap Compression Garment
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Vasovagal Syncope
Syncope Prediction Study
The purpose of this study is to perform a prospective evaluation of the vasovagal syncope prediction algorithm, called Tilt Test Analyzer, during head up tilt testing tests in one center in the United Kingdom.
- Trial name
- SPS (NCT02140567)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Medtronic BRC
Stroke
MTPr With Shockwave on Pain & Function of SHS in Stroke
Background: shoulder-hand syndrome is considered a significant reason for the reduction of upper limb functions after stroke. Purpose: To investigate the influence of Myofascial Trigger Points (MTrPs) release and shockwave…
- Trial name
- NCT04627636
- Testing
- Myofascial trigger points pressure (MTrP) release, Shockwave therapy application, conventional therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- October 6 University
Complex Regional Pain Syndrome Type I of the Upper Limb
Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS)
The purpose of this study is to test a specific nerve stimulation protocol as therapeutic option in patients diagnosed with CRPS (complex regional pain syndrome) of the upper extremity.
- Trial name
- NCT01915329
- Testing
- RSS (repetitive sensory stimulation)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Ruhr University of Bochum
Stroke
Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome
The study aims to determine the effects of task-based mirror therapy on edema, pain and upper limb motor function with shoulder-hand syndrome in post stroke patients.
- Trial name
- NCT07428811
- Testing
- Task based mirror therapy, Conventional exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Complex Regional Pain Syndromes
Prognostic Factors for Complex Regional Pain Syndrome
The investigators would like to examine the role of some relevant biopsychosocial factors in the development of persistent CRPS.
- Trial name
- CRPSPrognosis (NCT05337501)
- Testing
- Collecting data
- Where
- Belgium
- Volunteers
- 113 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Syncope, Vasovagal, Neurally-Mediated
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin.
- Trial name
- NCT06697145
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Wroclaw Medical University
Multiple System Atrophy, Dementia With Lewy Bodies (DLB)
Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and…
- Conditions
- Multiple System Atrophy, Dementia With Lewy Bodies (DLB), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD)
- Trial name
- NCT07805967
- Testing
- We did not apply any interventions; only observational research was conducted.
- Where
- 20 sites in China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Multiple System Atrophy, MSA - Multiple System Atrophy
Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early to Moderate Stage Multiple System Atrophy (MSA)
Purpose of this phase 1 study is to assess the safety of intrathecal administration of allogeneic human oral mucosa stem cells (hOMSCs) in patients suffering from early to moderate stage Multiple System Atrophy (MSA)
- Trial name
- NCT05698017
- Testing
- hOMSC300
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Cytora Ltd.
CRPS (Complex Regional Pain Syndromes)
Forward Looking InfraRed Imaging and Severity Score in Complex Regional Pain Syndrome
The goal of this interventional study is to explore the use of InfraRed (FLIR) imaging in determining pain intensity and severity in newly diagnosed complex regional pain syndrome patients.
- Trial name
- FLIR (NCT05852210)
- Testing
- Infrared Imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.