Clinical trials: Autonomic Nervous System
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, Autonomic Dysreflexia
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal…
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Baroreceptor Integrity, Sympathetic Integrity
- Trial name
- NCT02893553
- Testing
- Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Familial Dysautonomia
Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia
This is a pilot clinical trial of carbidopa to treat disabling attacks of nausea and vomiting in patients with familial dysautonomia (FD, also known as Riley Day syndrome or hereditary sensory and autonomic neuropathy type III).
- Trial name
- NCT01212484
- Testing
- Carbidopa
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05045625
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albany Medical College
Cluster Headache
A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache
This is a 68-week study to evaluate the long-term safety and efficacy of fremanezumab in participants with cluster headache (CH).
- Trial name
- ENFORCE (NCT03107052)
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 275 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple System Atrophy
Lithium in Multiple System Atrophy
The purpose of this study is to determine safety and tolerability of the treatment with lithium in Multiple System Atrophy. Moreover, clinical symptoms, neuronal loss, quality of life and depressive symptoms, will be considered…
- Trial name
- LAMU (NCT00997672)
- Testing
- Lithium Carbonate
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Orthostatic Hypotension, Spinal Cord Injury
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure.
- Trial name
- NCT00426842
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Familial Amyloid Polyneuropathy, Familial Amyloidosis
The Effect of Diflunisal on Familial Amyloidosis
The purpose of this study is to determine if diflunisal can prevent progressive lower leg nerve damage in patients with familial amyloidosis polyneuropathy.
- Trial name
- NCT00294671
- Testing
- diflunisal
- Where
- 8 sites in United States, Italy and 3 more
- Volunteers
- 130 people
- Sponsor
- Boston University
Type2 Diabetes, Cardiovascular Diseases
Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D)
The purpose of this study is to evaluate the effect of dapagliflozin, a FDA approved diabetes medication, on measures of nervous system function of the heart in patients with type 2 diabetes.
- Trial name
- NCT02973477
- Testing
- Dapagliflozin, Glimepiride
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
Parkinson Disease, Orthostatic Hypotension
Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease
Levodopa is a precursor of dopamine and is the treatment of choice to treat the motor symptoms of Parkinson's disease (PD); however, the effect of levodopa on cardiovascular autonomic function in PD is poorly understood.
- Trial name
- NCT05487300
- Testing
- Autonomic testing on and off levodopa
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Orthostatic Intolerance
Orthostatic Intolerance After Bariatric Surgery
More than 78 million adults in the U.S. are obese. Bariatric surgery is the only modality that results in sustained weight loss along with reversal of diabetes mellitus, and a decrease in cardiovascular events.
- Trial name
- RYGB (NCT03808740)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Advanced Stage Solid Tumors
ATRi Transition Rollover Study
The main purpose of the study was to monitor the safety of participant receiving long-term treatment of Berzosertib as monotherapy.
- Trial name
- NCT03309150
- Testing
- Berzosertib
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ataxia, Cerebellar, Cerebellar Ataxia
Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia
Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been…
- Conditions
- Ataxia, Cerebellar, Cerebellar Ataxia, Spinocerebellar Ataxias, Ataxia, Spinocerebellar
- Trial name
- CStDCSAtaxia (NCT03120013)
- Testing
- Anodal cerebellar and cathodal spinal tDCS
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Cardiac Resynchronization Therapy, Chronic Heart Failure
Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure
Cardiac resynchronization therapy(CRT) is recommended to reduce mortality and morbidity in chronic heart failure(CHF) patients New York Heart Association(NYHA) class III-IV who are symptomatic despite optimal medical therapy…
- Trial name
- NCT02413151
- Testing
- Exercise training program, Cardiac resynchronization therapy (CRT)
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- University of Lisbon
Episodic Cluster Headache, Chronic Cluster Headache
A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache
The main purpose of this study is to assess the long-term safety and tolerability of galcanezumab administered up to once monthly in participants with episodic or chronic cluster headache who have completed study I5Q-MC-CGAL…
- Trial name
- NCT02797951
- Testing
- Galcanezumab
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 165 people
- Sponsor
- Eli Lilly and Company
Postural Tachycardia Syndrome
Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
This study is to determine different chemical levels in the blood during a low salt diet. This study will compare normal volunteers to those with Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT01764711
- Testing
- Cosyntropin administration
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Parenteral Nutrition
Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN
Many hospitalized patients who are malnourished or not eating receive intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN2 (NCT00672854)
- Testing
- ClinOleic 20% Intravenous Emulsion, Intralipid, 20% Intravenous Emulsion
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Postoperative Ileus, Anastomotic Leak
SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition
The main objective is to investigate the effects of perioperative nutrition on postoperative ileus and anastomotic leakage in patients undergoing colorectal surgery.
- Trial name
- SANICSII (NCT02175979)
- Testing
- enriched enteral nutrition, standard
- Where
- 5 sites in Denmark, Netherlands
- Volunteers
- 280 people
- Sponsor
- Misha D.P. Luyer
Episodic Cluster Headache
A Study Of Galcanezumab In Participants With Episodic Cluster Headache
The main purpose of this study is to evaluate the efficacy and safety of the study drug known as Galcanezumab in participants with episodic cluster headaches.
- Trial name
- NCT02397473
- Testing
- Galcanezumab
- Where
- 47 sites in United States, Belgium and 10 more
- Volunteers
- 109 people
- Sponsor
- Eli Lilly and Company