Clinical trials: Autonomic Nervous System Disorders
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
NC Testing in LC & POTS
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction.
- Trial name
- NCT05914649
- Testing
- IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome, Hypocapnia
Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia
Postural tachycardia syndrome (POTS) is the most common chronic cause of postural lightheadedness, and upright confusion afflicting many Americans, mostly young women.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation
- Trial name
- NCT05923840
- Testing
- Chemoreflex Testing, Baroreflex testing, Orthostatic stress testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q5
When a patient with Type 1 diabetes exercises, he or she is more prone to low blood sugar, or hypoglycemia. It is known that antecedent exercise can blunt defense responses, called counterregulatory responses to subsequent…
- Trial name
- NCT00605774
- Testing
- epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Failed Back Surgery Syndrome, Complex Regional Pain Syndrome (CRPS)
A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain
This study is a prospective, single-arm, open label, single center pilot study to confirm the safety of a ultrahigh frequency DRG stimulator in patients with chronic lower limb pain. The actual trial length is 5 days.
- Trial name
- NCT03285113
- Testing
- GiMer Medical MN 1000 External Stimulator
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GiMer Medical
Parkinson Disease (PD), MSA - Multiple System Atrophy
Test-retest Trial With [11C]MODAG-005 in PD or MSA and AMHC - Pilot Phase
This is an open-label, single-center Phase 1 study evaluating the safety, tolerability, and test-retest characteristics of [11C]MODAG-005, an investigational positron emission tomography/computed tomography (PET/CT) radioligand…
- Conditions
- Parkinson Disease (PD), MSA - Multiple System Atrophy, Healthy Adult Participants
- Trial name
- PIOSA (NCT07640542)
- Testing
- [11C]MODAG-005
- Where
- Germany
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Normal Tension Glaucoma
Autonomic Nervous System Activity and Normal Tension Glaucoma
Evidence has accumulated that systemic and ocular mechanisms, responsible for regulating blood flow in the area of the optic disc, such as reduced ocular perfusion pressure, abnormal autoregulation and vascular dysregulation may…
- Trial name
- ANS (NCT01192061)
- Where
- Poland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Military Institute od Medicine National Research Institute
Phobia
Biobehavioral Correlates of Acute Phobic Fear
This study seeks to measure the time course of circulating proinflammatory markers (interleukin-1 beta [IL-1β], interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-α], and C-reactive protein [CRP]) and salivary alpha amylase…
- Trial name
- NCT03813823
- Testing
- Fear tasks
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Healthy, Psychological Distress
The Effects of the Somatic Intervention 'Dance-Walk' on Body Awareness, Vitality, and Mental Health in Help-Seeking Adults: a RCT Study
The goal of this clinical trial is to learn if a movement program called "Dance-Walk" can improve body awareness, energy levels, and mental health in adults seeking mental health support.
- Conditions
- Healthy, Psychological Distress, Stress, Depression Disorders
- Trial name
- DANCEWALK (NCT07024901)
- Testing
- Dance-walk
- Where
- Lithuania
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Reflex Sympathetic Dystrophy
Near-infrared Spectroscopic Measurement in Complex Regional Pain Syndrome
Recent clinical investigations have suggested that the cause of abnormal pain in complex regional pain syndrome could be ischemia and inflammation, due to poor blood flow to deep tissues from microvascular pathology.
- Trial name
- NCT01586377
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Orthostatic Intolerance, Parkinson's Disease
Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine
This study will evaluate whether treatment with the α1-agonist, midodrine, reduces subjective orthostatic lightheadedness as measured by the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS) questionnaire, in patients with…
- Trial name
- NCT02365012
- Testing
- Midodrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Parkinson Disease Dementia, Parkinson Disease
Community Outreach for Palliative Engagement -- Parkinson Disease
The purpose of this study is to learn more about the effectiveness of palliative care training for community physicians and telemedicine support services for patients and carepartners with Parkinson's disease and Lewy Body…
- Conditions
- Parkinson Disease Dementia, Parkinson Disease, Parkinson's Disease and Parkinsonism, Lewy Body Parkinsonism
- Trial name
- COPE-PD (NCT05222386)
- Testing
- Parkinson Disease Standard Care, Online Community-Supported Palliative Care
- Where
- United States
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cluster Headache, Headache Disorders
Resting State Functional Connectivity in Cluster Headache
Cluster headache is a highly disabling primary headache disorder, characterized by severe, excruciating, recurrent unilateral headache attacks.
- Trial name
- NCT06206772
- Testing
- Resting state HD-EEG recording
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Complex Regional Pain Syndrome, Peripheral Nerve Injuries
Somatosensory Assessment and Rehabilitation of Allodynia (SARA)
This pilot study will test a new therapy, somatosensory rehabilitation, for the painful sensitivity experienced by persons with nerve injuries and/or complex regional pain syndrome (CRPS).
- Conditions
- Complex Regional Pain Syndrome, Peripheral Nerve Injuries, Hand Fractures
- Trial name
- SARA (NCT02070367)
- Testing
- Somatosensory rehabilitation, Usual treatment: physiotherapy
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury
Hydroxyephedrine PET/CT in Sympathetic Nervous System Disease
To evaluate the potential usefulness of 11C/18F-HED positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.
- Conditions
- Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury, Sympathetic Nerve Injury
- Trial name
- NCT06951984
- Testing
- 11C/18F-HED
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Sleep Apnea Syndromes
Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
The prevalence of obstructive sleep apnea is high in the Veteran population. If not treated promptly, sleep apnea may result in daytime fatigue which may lead to increased prevalence of accidents while driving or in the…
- Trial name
- RAP-IH (NCT00860743)
- Testing
- Antioxidant cocktail
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Autonomic Dysfunction, Autonomic Imbalance
Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors
The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV).
- Conditions
- Autonomic Dysfunction, Autonomic Imbalance, Blood Loss
- Trial name
- NCT04499664
- Testing
- Monitoring of the autonomic nervous system
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Healthy Volunteers
A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects
The purpose of this study is to determine the safety, tolerability and blood levels of orally administered anle138b in healthy subjects.
- Trial name
- NCT04208152
- Testing
- anle138b
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Healthy
Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis.
- Trial name
- SYNAPSE (NCT00766584)
- Testing
- Sleep apnea/hypopnea detection
- Where
- France
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Type 2 Diabetes, Cardiovascular Autonomic Neuropathy
Neurovascular Coupling and Autonomic Neuropathy in Type 2 Diabetes
Diabetes is a growing global health care challenge. Diabetes patients may also suffer from cardiovascular autonomic neuropathy (CAN) which may affect cerebral perfusion.
- Trial name
- NCT04625751
- Testing
- CO2-enriched air, Meal response test
- Where
- 2 sites in Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Hartwig R. Siebner