Clinical trials: Autonomic Nervous System Disorders
Amyotrophic Lateral Sclerosis
Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS
The goal of this interventional non-pharmacological study is to evaluate, using a multimodal approach, the progression of autonomic and sensory involvement in in amyotrophic lateral sclerosis (ALS) patients enrolled within 18…
- Trial name
- NCT05747937
- Testing
- Skin biopsy, Cardiovascular Reflexes testing, Administration of clinical scales evaluating autonomic symptoms, pain small fiber neuropathy symptoms
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Postural Tachycardia Syndrome
Dopamine in Orthostatic Tolerance
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate.
- Trial name
- NCT00748228
- Testing
- dietary sodium
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postexercise Hypotension
Continuous vs Aerobic Postexercise Hypotension
This study examines the effect of obesity and gender on postexercise hypotension with three different randomized exercise protocols or varying intensity.
- Trial name
- CAPER (NCT03313375)
- Testing
- Continuous Exercise, Aerobic Interval Exercise
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Multiple System Atrophy
Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that cause as other neurodegenerative diseases profound declines in functioning and thus, require caregiving for assistance with daily living.
- Trial name
- QUA2-AMS (NCT04965922)
- Testing
- Multimodal intervention
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Fibromyalgia
Electrophysiological Findings in Fibromyalgia Patients
Fibromyalgia Syndrome (FMS); It is a chronic condition characterized by widespread body pain, sleep disturbance, fatigue, impaired cognitive functions, and anxiety (1).
- Trial name
- NCT04845737
- Testing
- sympathetic skin response measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Pain
Pilot Study of the Effect of Transcutaneous Stimulation of the Vagus Nerve on Pain Perception and Parameters of the Autonomic Nervous System
The increased incidence of pain syndromes requires the investigation of pathophysiological coherences as well as searching for new therapies.
- Trial name
- NCT01174498
- Testing
- Cerbomed t-VNS® transcutaneous stimulation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- cerbomed GmbH
Analgesia
The Effects of Pain and Pain Relief on Peripheral Nerve Excitability
This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.
- Trial name
- NCT06356376
- Testing
- Heat Stimulation
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Postural Tachycardia Syndrome, Orthostatic Tachycardia
Acute Salt Handling in Orthostatic Intolerance
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control…
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
- Trial name
- NCT00581633
- Testing
- normal saline (0.9%)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Neuropathy; Peripheral, Autonomic, in Diabetes Mellitus (Manifestation)
The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy
Exploring the relationship between serum VAP-1 and cardiovascular autonomic neuropathy in subjects with type 2 diabetes mellitus
- Trial name
- NCT01706289
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Polyphenols, Cardiovascular Diseases
Autonomic and Cardiovascular Recovery After the Acute Use of Resveratrol in Overweight and Obesity Individuals
The aim of this study is to understand the importance of resveratrol supplementation as a possible adjuvant in improving the metabolic profile and cardiovascular autonomic recovery of individuals with overweight and grade I…
- Conditions
- Polyphenols, Cardiovascular Diseases, Autonomic Nervous System
- Trial name
- Resveratrol (NCT06020313)
- Testing
- Resveratrol Experimental
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taisy Cinthia Ferro Cavalcante
Neuropathic Pain, Depression
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders.
- Conditions
- Neuropathic Pain, Depression, Cognitive Impairment, Somatic Neuropathy
- Trial name
- NCT02099890
- Testing
- Omega-3, Vegetation Protein Powder, InflanNox
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brock University
Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital…
- Trial name
- NCT06219655
- Testing
- thoracoscopic sympathectomy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Mild Traumatic Brain Injury, Concussion, Mild
Exercise as Concussion Therapy Trial- 2
This study is a Phase 2, open-label study of a therapeutic intervention (graded exercise)compared to a reference therapy (passive stretching) in patients who have sustained mTBI.
- Trial name
- ExACTT (NCT04578743)
- Testing
- Graded Exercise Therapy: ClearPlay(TM)
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANSwers Neuroscience, Inc.
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q4-Atomoxetine
This study is aimed at determining if the drug Atomoxetine (Strattera-used to treat Attention Deficit Hyperactivity Disorder(ADHD) has effects on the body's ability to defend itself against low blood sugar.
- Trial name
- NCT00780650
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy
Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of single and multiple ascending doses of rhNGF when administered as eye drops in healthy subjects.
- Trial name
- NGF0112 (NCT01744704)
- Testing
- rhNGF 0.5 µg/mL Sentinel, rhNGF 5 µg/mL Sentinel, rhNGF 20 µg/mL Sentinel
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Fibromyalgia, Exercise
Cardiovascular Autonomic Function and Endogenous Pain Modulation
The study has three aims: 1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched controls 2.
- Conditions
- Fibromyalgia, Exercise, Pain, Autonomic Dysfunction
- Trial name
- NCT03911609
- Testing
- Exercise, Cognitive Task
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marquette University
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Syncope, Vasovagal
Respiration and Applied Tension Strategies to Reduce Vasovagal Reactions to Blood Donation
For a number of years, researchers have examined the effects of the muscle-tensing technique, Applied Tension (AT), on blood donation-related vasovagal symptoms and donor retention.
- Trial name
- NCT03159156
- Testing
- Applied Tension, Respiration Control, Applied Tension/Respiration Control
- Where
- Canada
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- McGill University
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Elevations of plasma cortisol, a stress hormone, during prior episodes of low blood sugar (hypoglycemia) appear to be responsible for the deficient responses during subsequent hypoglycemia.
- Trial name
- NCT00607646
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore