Clinical trials: Autonomic Nervous System Disorders
Cluster Headache, Trigeminal Autonomic Cephalgia
Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache Patients
The physiopathology of trigeminal-autonomic cephalalgia, and more particularly of cluster headache (CH) is still partially unknown.
- Trial name
- DETECT (NCT05857098)
- Testing
- Local Field potential recording
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
Synaptic Loss in Multiple System Atrophy
In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA), and pathology…
- Trial name
- NCT05121012
- Testing
- Study procedures for MSA patients, Study procedures for PSP patients
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Exeter
Hypertension
Postexercise Hypotension and Exercise Adherence
Sedentary (n=24) adults ≥18 yr with elevated BP to established hypertension were enrolled into this randomized clinical trial entitled, 'Blood Pressure UtiLizing Self-Monitoring after Exercise study or PULSE'.
- Trial name
- NCT03780309
- Testing
- Exercise Self-Monitoring, Blood Pressure Self-Monitoring
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Fibromyalgia, Exercise
Cardiovascular Autonomic Function and Endogenous Pain Modulation
The study has three aims: 1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched controls 2.
- Conditions
- Fibromyalgia, Exercise, Pain, Autonomic Dysfunction
- Trial name
- NCT03911609
- Testing
- Exercise, Cognitive Task
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marquette University
Auditory Perceptual Disorders, Stress Disorder
The Listening Project at the ADD Centre and Biofeedback Institute of Toronto
Purpose: A research project will be conducted at the ADD ("Attention Deficit Disorder") Centre and Biofeedback Institute of Toronto to evaluate the feasibility of the Listening Project Protocol (LPP) intervention in individuals…
- Trial name
- NCT02680730
- Testing
- Listening Project Protocol
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Multiple System Atrophy, Parkinson Disease
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
This is a non-interventional observational study designed to systematically record the results of routine laryngeal examinations and specific characteristics of dysphagia in patients with neurodegenerative disorders.
- Conditions
- Multiple System Atrophy, Parkinson Disease, Progressive Supranuclear Palsy, Motor Neuron Disease
- Trial name
- FEEMSA (NCT04706234)
- Where
- 16 sites in Austria, Germany and 6 more
- Volunteers
- 350 people
- Sponsor
- Kliniken Beelitz GmbH
Vasovagal Syncope
Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope
Objective: To determine if atomoxetine 40 mg bid (bis in die) in patients ≥18 years old with recurrent vasovagal syncope will better prevent syncope during tilt testing than placebo.
- Trial name
- POST6 (NCT02500732)
- Testing
- Atomoxetine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Spinal Cord Injuries, Hypotension
Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury
The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- (SCI) (NCT07674511)
- Testing
- Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Vasomotor Symptoms, Hot Flashes
HIRREM Hot Flashes Study
The purpose of this research study is to determine the effects of a technique called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®), for women in any stage of menopause, who are experiencing…
- Conditions
- Vasomotor Symptoms, Hot Flashes, Menopause
- Trial name
- NCT03512002
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Insomnia, Sleep Initiation and Maintenance Disorders
Sleep Efficacy Randomized Evaluation of a Novel Digital Therapeutic for Insomnia
This study is a multicenter, randomized, double-blind, sham-controlled clinical investigation designed to evaluate the effectiveness and safety of BELL-001, a digital therapeutic developed to improve symptoms of insomnia.
- Trial name
- SERENE (NCT07295431)
- Testing
- BELL-001 Digital Therapeutic
- Where
- 6 sites in South Korea
- Volunteers
- 116 people
- Sponsor
- BELL Therapeutics Inc.
Multiple System Atrophy
A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy
This is a Phase 2, double-blind, placebo-controlled, multi-center, Phase II, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and efficacy of Ya-101 in subjects with multiple system atrophy.
- Trial name
- NCT06848231
- Testing
- YA-101
- Where
- 9 sites in United States, Japan and 1 more
- Volunteers
- 75 people
- Sponsor
- Dasher Neuroscience Inc.
Brachial Plexus Block, Horner Syndrome
The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity
This study evaluates the effects of Horner's syndrome on cardiac autonomic nervous activity after interscalene brachial plexus block.
- Conditions
- Brachial Plexus Block, Horner Syndrome, Autonomic Imbalance
- Trial name
- NCT03514342
- Testing
- Interscalene brachial plexus block, 0.75% ropivacaine
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Daegu Catholic University Medical Center
Episodic Cluster Headache
Civamide Nasal Solution for Cluster Headache
The purpose of this study is to evaluate the safety and efficacy of intranasally administered civamide nasal solution in the prevention of cluster headaches during an episodic cluster headache period.
- Trial name
- ECH (NCT01341548)
- Testing
- Civamide nasal solution 0.01%
- Volunteers
- 180 people
- Sponsor
- Winston Laboratories
Orthostatic Hypotension, Nondipping Hypertension
Is Orthostatic Hypotension Associated With Nondipping Hypertension
The aim of the study is to evaluate whether orthostatic hypotension is associated with nondipping hypertension. Methods and patients: 400 subjects who are referred for 24hABPM will be filled questioner regarding their medical…
- Trial name
- NCT00491231
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Sleep Apnea Syndromes
Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
The prevalence of obstructive sleep apnea is high in the Veteran population. If not treated promptly, sleep apnea may result in daytime fatigue which may lead to increased prevalence of accidents while driving or in the…
- Trial name
- RAP-IH (NCT00860743)
- Testing
- Antioxidant cocktail
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital…
- Trial name
- NCT06219655
- Testing
- thoracoscopic sympathectomy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Multiple System Atrophy, Parkinsonism
Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy
The prevalence of Multiple System Atrophy (MSA) is reported to be between 3.4 - 4.9 cases per 100,000 population. The estimated average incidence is 0.6 - 0.7 cases per 100,000 people per year.
- Conditions
- Multiple System Atrophy, Parkinsonism, Multiple System Atrophy, Parkinson Variant
- Trial name
- NCT04876326
- Testing
- Autologous Adipose Mesenchymal Stem Cell Implantation, Allogeneic Umbilical Cord Mesenchymal Stem Cell Implantation, Allogeneic Umbilical Cord Mesenchymal Stem Cell and Adipose Secretome Implantation
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Indonesia
Fibromyalgia
Peripheral Arterial Tonometry (PAT) Evaluation of Sleep in Fibromyalgia
Fibromyalgia syndrome (FMS) is characterized by the presence of widespread pain, chronic fatigue and typical sleep disturbances.
- Trial name
- NCT01151163
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR
The purpose of this study is to determine if a drug called netarsudil is safe and able to prevent the development of scar tissue after retinal detachment repair.
- Trial name
- NCT05660447
- Testing
- Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Glycerin 0.2%/Hypromellose 0.2%/Peg 1%/Soln,Oph,Ud
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wills Eye
Lymphoma, Myeloma
Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation
The hospitalization for hematopoietic stem cell transplantation (HSCT) impairs the physical functioning and functional capacity, but aerobic physical training and, more recently, inspiratory muscle training, have shown benefits…
- Conditions
- Lymphoma, Myeloma, Leukemia, Aplastic Anemia
- Trial name
- NCT03373526
- Testing
- Inspiratory Muscle Training, Aerobic Training
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Daniel Godoy Martinez
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