Clinical trials: Autonomic Nervous System Disorders
Postural Tachycardia Syndrome
A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia Syndrome
The investigators hope to learn the feasibility and preliminary efficacy of the Embr device for improving thermal comfort in individuals with POTS and impaired thermoregulation.
- Trial name
- NCT04943276
- Testing
- Embr Device
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Osteoarthritis, Rheumatoid Arthritis
Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216)
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- HZ-CA-304 (NCT00613106)
- Testing
- HZT-501, Ibuprofen
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Amgen
Esophageal Cancer
Evaluation of the Autonomic Nervous System in Patients Undergoing Esophagectomy for Cancer
Esophageal surgery is a complex surgery, with high post-operative morbidity and mortality. The incidence of complications associated with esophagectomy varies from 17% to 74%, in the literature.
- Trial name
- PROSNACO (NCT04835987)
- Testing
- Holter ECG, Questionary, Pupillometry
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Coronary Syndrome, Myocardial Ischemia
Linking Cardiac Autonomic Dysfunction and InfLammation in Patients With Acute Coronary Syndromes
Subclinical inflammation plays a critical role in all stages of the atherosclerotic process, from the initiation of the fatty streaks to the development of plaque instability and rupture, causing myocardial ischemia and acute…
- Trial name
- CADILACS (NCT05756452)
- Testing
- Anamnesis and clinical evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Complex Regional Pain Syndrome
Comparative Effects of Mirror Therapy and Standard Physiotherapy in Complex Regional Pain Syndrome
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition characterized by persistent pain, sensory disturbances, motor dysfunction, and functional impairment, often following trauma or surgery.
- Trial name
- (CRPS) (NCT07332884)
- Testing
- Mirror Therapy, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- University of Lahore
Multiple System Atrophy
Study of Rifampicin in Multiple System Atrophy
The purpose of this study was to determine whether Rifampicin was effective in slowing or reversing the progression of multiple system atrophy (MSA).
- Trial name
- MSA (NCT01287221)
- Testing
- Rifampicin
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Phillip Low
Fibromyalgia
Effectiveness of Tai Chi on Cardiac Autonomic Function and Symptomatology in Women With Fibromyalgia: a Randomized Controlled Trial
Fibromyalgia (FM) is an idiopathic disease affecting approximately 3% of the world population, primarily diagnosed in middle-aged women.
- Trial name
- NCT03016585
- Testing
- Tai Chi Training
- Volunteers
- 37 people
- Sponsor
- Pusan National University
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
The purpose of this study is to determine what corticosteroid receptor (and the dose of) is responsible for cortisol inducing hypoglycemia associated autonomic dysfunction in Type 1 DM.
- Trial name
- NCT00608101
- Testing
- Fludrocortisone, Dexamethasone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Orthostatic Hypotension
Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy
Patients who will undergo colonoscopy accompanied by sedoanalgesia will be admitted at Aksaray Training and Research Hospital Gastroenterology Clinic between May and July 2024.
- Trial name
- NCT06439498
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara University
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Diabetic Neuropathies
Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the safety and effectiveness of TAK-583, once daily (QD), in the treatment of neuropathy caused by diabetes mellitus.
- Trial name
- NCT00760955
- Testing
- TAK-583
- Where
- 38 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Takeda
Solid Tumors
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT04774952
- Testing
- RMC-5552
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Revolution Medicines, Inc.
Postural Tachycardia Syndrome
The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome
The purpose of this study is to determine whether Ivabradine is an effective treatment for postural tachycardia syndrome.
- Trial name
- NCT01761825
- Testing
- ivabradine
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Complex Regional Pain Syndrome, Carpal Tunnel Syndrome
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
This study aims for a better understanding of the pathophysiological mechanisms of the complex regional pain syndrome (CRPS). This will be done by testing the quantitative sensory testing, the remote ischemic conditioning, the…
- Conditions
- Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, Neuralgia
- Trial name
- NCT02261012
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Multiple System Atrophy
Safety and Tolerability of CS10BR05 Inj. in Subjects with Multiple System Atrophy
The purpose of conducting phase 1 trial is to evaluate the safety and tolerability of autologous bone marrow-derived mesenchymal stem cells(CS10BR05) in subjects with Multiple System Atrophy.
- Trial name
- NCT03265444
- Testing
- CS10BR05
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Corestemchemon, Inc.
Postherpetic Neuralgia, Complex Regional Pain Syndromes (CRPS)
A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome
The purpose of this study is to evaluate the efficacy and safety of fentanyl in opioid-naive participants with post-herpetic neuralgia, complex regional pain syndrome or post-operative pain syndrome who cannot obtain a sufficient…
- Conditions
- Postherpetic Neuralgia, Complex Regional Pain Syndromes (CRPS), Postoperative Pain
- Trial name
- NCT01008553
- Testing
- Fentanyl
- Where
- 79 sites in Japan
- Volunteers
- 258 people
- Sponsor
- Janssen Pharmaceutical K.K.
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Bipolar Depression
Neurophysiologic Changes in Patients With Bipolar Depression
To examine differences in neurophysiologic parameters between unmedicated patients with bipolar depression and healthy controls To examine within-subject changes in neurophysiologic parameters in patients with bipolar depression…
- Trial name
- NCT01213121
- Testing
- Quetiapine
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Complex Regional Pain Syndrome, Type I
Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I
This clinical trial is being conducted to demonstrate the efficacy of neridronic acid in the treatment of pain associated with complex regional pain syndrome type I (CRPS-I).
- Trial name
- NCT02402530
- Testing
- Neridronic acid 62.5 mg
- Where
- 59 sites in United States, Germany and 1 more
- Volunteers
- 459 people
- Sponsor
- Grünenthal GmbH
PSP, CBD
Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
The investigators aim to learn more about symptoms suggestive of a neurodegenerative process.
- Conditions
- PSP, CBD, PCA, LPA
- Trial name
- AND1 (NCT04680130)
- Testing
- C-11 PiB, AV1451 Tau, C-11 ER176
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
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