Clinical trials: Autonomic Nervous System Dysfunction
Chronic Low Back Pain (CLBP), Heart Rate Variability
Autonomic Differences in Heart Rate Variability Between Healthy and Chronic Low Back Pain Subjects
This study aims to evaluate the autonomic differences in heart rate variability (HRV) between healthy individuals and those with chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Heart Rate Variability, Autonomic Nervous System Dysfunction
- Trial name
- NCT06760390
- Where
- Spain
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment
This study is testing a new treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long-term symptoms after COVID-19.
- Trial name
- REenergizeME (NCT07317401)
- Testing
- Intermittent hypoxia-hyperoxia treatment (IHHT)
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Shoulder Pain, Rotator Cuff Related Shoulder Pain
HIIT for Inflammatory-driven Shoulder Pain.
This feasibility study investigates whether high-intensity interval training (HIIT) is feasible and acceptable for individuals with long-term shoulder pain where low-grade inflammation is suspected.
- Conditions
- Chronic Shoulder Pain, Rotator Cuff Related Shoulder Pain, Frozen Shoulder, Shoulder Adhesive Capsulitis
- Trial name
- NCT07275164
- Testing
- High intensity interval training (HIIT)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Parkinson Disease, Dementia With Lewy Bodies
[18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DLB vs. AD
Study goal: The goal of this prospective head to head comparison is to evaluate the effectiveness of [18F]-MFBG PET in assessing cardiac innervation, comparing it with [123I]-MIBG SPECT The study's primary focus is on…
- Conditions
- Parkinson Disease, Dementia With Lewy Bodies, MSA - Multiple System Atrophy, Alzheimer Disease
- Trial name
- NCT06120049
- Testing
- [18F]-MFBG PET CT, [18F]-FE-PE2I PET CT or PET MRI, [123I]-MIBG SPECT CT
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Diabetes Complications
Dose Response of Epinephrine
Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial function and atherothrombotic balance in…
- Trial name
- Epineprhine (NCT02692313)
- Testing
- Epinephrine, Saline infusion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Autonomic Dysfunction
Autonomic Regulation in Prader-Willi Syndrome
To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.
- Trial name
- NCT04118816
- Testing
- Polysomnography, Multiple sleep latency test, Continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
HIV, Non-HIV
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
The study team's prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO is associated with signs of inflammation in…
- Conditions
- HIV, Non-HIV, Vagus Nerve Dysfunction
- Trial name
- EVA (NCT04353778)
- Testing
- Pyridostigmine, non-invasive vagal nerve stimulation
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction Question 2
The purpose of this study is to determine the way by which Alprazolam (Xanax) an anti-anxiety drug affects specialized molecules in your brain called GABA (A) receptors that alter your body's ability to defend itself from low…
- Trial name
- Alp Ex (NCT00574639)
- Testing
- Alprazolam
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Microvascular Coronary Dysfunction
Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain impacts women.
- Trial name
- NCT01568177
- Testing
- Mental Stress Testing, Peripheral Arterial Tonometry (PAT) Testing, Heart Rate Variability (HRV)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Autonomic Dysfunction
Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training
Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group.
- Trial name
- NCT05135247
- Testing
- Exercise
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Parkinson Disease
Parkinson Disease Before and After Medication and Rehabilitation Treatment
In this three-year project, our research teams are going to consecutively explore these important clinical, drug and physical rehabilitation treatment effects, noradrenergic network, autonomic dysfunction and microRNA signalling…
- Trial name
- NCT02672943
- Testing
- Rehabilitation treatment, non-rehabilitation treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fibromyalgia, Exercise
Cardiovascular Autonomic Function and Endogenous Pain Modulation
The study has three aims: 1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched controls 2.
- Conditions
- Fibromyalgia, Exercise, Pain, Autonomic Dysfunction
- Trial name
- NCT03911609
- Testing
- Exercise, Cognitive Task
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marquette University
Insulin Resistance, Autonomic Dysfunction
Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity
The aim of this project is to determine role for ET-1 in individuals with obesity.
- Conditions
- Insulin Resistance, Autonomic Dysfunction, Obesity
- Trial name
- NCT05518422
- Testing
- Hyperinsulinemic, euglycemic infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia